IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0141455.html

A Cluster Randomised Trial on the Impact of Integrating Early Infant HIV Diagnosis with the Expanded Programme on Immunization on Immunization and HIV Testing Rates in Rural Health Facilities in Southern Zambia

Author

Listed:
  • Paul C Wang
  • Albert Mwango
  • Sarah Moberley
  • Benjamin J Brockman
  • Alison L Connor
  • Penelope Kalesha-Masumbu
  • Simon Mutembo
  • Maximillian Bweupe
  • Pascalina Chanda-Kapata
  • Godfrey Biemba
  • Davidson H Hamer
  • Benjamin Chibuye
  • Elizabeth McCarthy

Abstract

Background: We assessed the integration of early infant HIV diagnosis with the expanded programme for immunization in a rural Zambian setting with the aim of determining whether infant and postpartum maternal HIV testing rates would increase without harming immunization uptake. Methods: In an unblinded, location stratified, cluster randomised controlled trial, 60 facilities in Zambia’s Southern Province were equally allocated to a control group, Simple Intervention group that received a sensitization meeting and the resupply of HIV testing commodities in the event of a stock-out, and a Comprehensive Intervention group that received the Simple Intervention as well as on-site operational support to facilitate the integration of HIV testing services with EPI. Findings: The average change in number of first dose diphtheria, pertussis, and tetanus vaccine (DPT1) provided per month, per facility was approximately 0.86 doses higher [90% confidence interval (CI) -1.40, 3.12] in Comprehensive Intervention facilities compared to the combined average change in the Simple Intervention and control facilities. The interventions resulted in a 16.6% [90% CI: -7%, 46%, P-value = 0.26] and 10% [90% CI: -10%, 36%, P-value = 0.43] greater change in average monthly infant DBS testing compared to control for the Simple and Comprehensive facilities respectively. We also found 15.76 (90% CI: 7.12, 24.41, P-value

Suggested Citation

  • Paul C Wang & Albert Mwango & Sarah Moberley & Benjamin J Brockman & Alison L Connor & Penelope Kalesha-Masumbu & Simon Mutembo & Maximillian Bweupe & Pascalina Chanda-Kapata & Godfrey Biemba & Davids, 2015. "A Cluster Randomised Trial on the Impact of Integrating Early Infant HIV Diagnosis with the Expanded Programme on Immunization on Immunization and HIV Testing Rates in Rural Health Facilities in Southern Zambia," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0141455
    DOI: 10.1371/journal.pone.0141455
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141455
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0141455&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0141455?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Guido W. Imbens & Jeffrey M. Wooldridge, 2009. "Recent Developments in the Econometrics of Program Evaluation," Journal of Economic Literature, American Economic Association, vol. 47(1), pages 5-86, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hauzenberger, Niko & Huber, Florian & Klieber, Karin & Marcellino, Massimiliano, 2025. "Bayesian neural networks for macroeconomic analysis," Journal of Econometrics, Elsevier, vol. 249(PC).
    2. repec:plo:pone00:0135879 is not listed on IDEAS
    3. Robertson, Raymond, 2019. "Working Conditions, Transparency, and Compliance in Global Value Chains: Evidence from Better Work Jordan," IZA Discussion Papers 12794, IZA Network @ LISER.
    4. Tiziano Arduini & Eleonora Patacchini & Edoardo Rainone, 2020. "Treatment Effects With Heterogeneous Externalities," Journal of Business & Economic Statistics, Taylor & Francis Journals, vol. 38(4), pages 826-838, October.
    5. Sant’Anna, Pedro H.C. & Zhao, Jun, 2020. "Doubly robust difference-in-differences estimators," Journal of Econometrics, Elsevier, vol. 219(1), pages 101-122.
    6. Peydró, José-Luis & Jiménez, Gabriel & Kenan, Huremovic & Moral-Benito, Enrique & Vega-Redondo, Fernando, 2020. "Production and financial networks in interplay: Crisis evidence from supplier-customer and credit registers," CEPR Discussion Papers 15277, C.E.P.R. Discussion Papers.
    7. Msangi, Haji Athumani & Löhr, Katharina & Sieber, Stefan & Waized, Betty & Ndyetabula, Daniel Wilson, 2023. "Maximizing impact: The power of combining land tenure formalization and productive social safety nets programmes in Tanzania," 2023 Seventh AAAE/60th AEASA Conference, September 18-21, 2023, Durban, South Africa 365859, African Association of Agricultural Economists (AAAE).
    8. Stojčić, Nebojša, 2021. "Social and private outcomes of green innovation incentives in European advancing economies," Technovation, Elsevier, vol. 104(C).
    9. J. David Brown & John S. Earle, 2012. "Do SBA Loans Create Jobs? Estimates from Universal Panel Data and Longitudinal Matching Methods," Working Papers 12-27, Center for Economic Studies, U.S. Census Bureau.
    10. Bobonis, Gustavo J. & Morrow, Peter M., 2014. "Labor coercion and the accumulation of human capital," Journal of Development Economics, Elsevier, vol. 108(C), pages 32-53.
    11. Salvatore Bimonte & Antonella D’Agostino, 2021. "Tourism development and residents’ well-being: Comparing two seaside destinations in Italy," Tourism Economics, , vol. 27(7), pages 1508-1525, November.
    12. Chenchuan (Mark) Li & Ulrich K. Müller, 2021. "Linear regression with many controls of limited explanatory power," Quantitative Economics, Econometric Society, vol. 12(2), pages 405-442, May.
    13. repec:osf:osfxxx:s8ayp_v1 is not listed on IDEAS
    14. Irina Heimbach & Oliver Hinz, 2018. "The Impact of Sharing Mechanism Design on Content Sharing in Online Social Networks," Information Systems Research, INFORMS, vol. 29(3), pages 592-611, September.
    15. Takahashi, Ryo, 2021. "How to stimulate environmentally friendly consumption: Evidence from a nationwide social experiment in Japan to promote eco-friendly coffee," Ecological Economics, Elsevier, vol. 186(C).
    16. Josep Garcia-Blandon & Josep Maria Argilés-Bosch & Diego Ravenda & David Castillo-Merino, 2025. "Breaking barriers: assessing the influence of female directors on financial performance beyond the boardroom," Review of Managerial Science, Springer, vol. 19(10), pages 3111-3141, October.
    17. Marco Caliendo & Stefan Tübbicke, 2020. "New evidence on long-term effects of start-up subsidies: matching estimates and their robustness," Empirical Economics, Springer, vol. 59(4), pages 1605-1631, October.
    18. Maya M. Papineau, 2015. "Setting the Standard: Commercial Electricity Consumption Responses to Energy Codes," Carleton Economic Papers 15-05, Carleton University, Department of Economics.
    19. Pablo Lavado & Gonzalo Rivera, 2016. "Identifying Treatment Effects with Data Combination and Unobserved Heterogeneity," Working Papers 79, Peruvian Economic Association.
    20. Amiti, Mary & Duprez, Cédric & Konings, Jozef & Van Reenen, John, 2024. "FDI and superstar spillovers: Evidence from firm-to-firm transactions," Journal of International Economics, Elsevier, vol. 152(C).
    21. Caloffi, Annalisa & Freo, Marzia & Ghinoi, Stefano & Mariani, Marco & Rossi, Federica, 2022. "Assessing the effects of a deliberate policy mix: The case of technology and innovation advisory services and innovation vouchers," Research Policy, Elsevier, vol. 51(6).
    22. Shaibu Baanni Azumah & Abraham Zakaria & Rosaine N. Yegbemey & Philips A. Apalogta & Vishal Dagar & Abass Mahama, 2022. "Climate Smart Production, Gross Income, and Downstream Risk Characterization of Rice Farmers in Ghana," Journal of Agricultural Studies, Macrothink Institute, vol. 10(2), pages 13-35, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0141455. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.