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A Systematic Review and Meta-Analysis on the Safety of Vascular Endothelial Growth Factor (VEGF) Inhibitors for the Treatment of Retinopathy of Prematurity

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Listed:
  • Laura Pertl
  • Gernot Steinwender
  • Christoph Mayer
  • Silke Hausberger
  • Eva-Maria Pöschl
  • Werner Wackernagel
  • Andreas Wedrich
  • Yosuf El-Shabrawi
  • Anton Haas

Abstract

Introduction: Laser photocoagulation is the current gold standard treatment for proliferative retinopathy of prematurity (ROP). However, it permanently reduces the visual field and might induce myopia. Vascular endothelial growth factor (VEGF) inhibitors for the treatment of ROP may enable continuing vascularization of the retina, potentially allowing the preservation of the visual field. However, for their use in infants concern remains. This meta-analysis explores the safety of VEGF inhibitors. Methods: The Ovid Interface was used to perform a systematic review of the literature in the databases PubMed, EMBASE and the Cochrane Library. Results: This meta-analysis included 24 original reports (including 1.457 eyes) on VEGF inhibitor treatment for ROP. The trials were solely observational except for one randomized and two case-control studies. We estimated a 6-month risk of retreatment per eye of 2.8%, and a 6-month risk of ocular complication without the need of retreatment of 1.6% per eye. Systemic complications were only reported as isolated incidents. Discussion: VEGF inhibitors seem to be associated with low recurrence rates and ocular complication rates. They may have the benefit of potentially allowing the preservation of visual field and lower rates of myopia. Due to the lack of data, the risk of systemic side effects cannot be assessed.

Suggested Citation

  • Laura Pertl & Gernot Steinwender & Christoph Mayer & Silke Hausberger & Eva-Maria Pöschl & Werner Wackernagel & Andreas Wedrich & Yosuf El-Shabrawi & Anton Haas, 2015. "A Systematic Review and Meta-Analysis on the Safety of Vascular Endothelial Growth Factor (VEGF) Inhibitors for the Treatment of Retinopathy of Prematurity," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0129383
    DOI: 10.1371/journal.pone.0129383
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    References listed on IDEAS

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    1. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
    2. Jin-Wei Cheng & Shi-Wei Cheng & Guo-Cai Lu & Rui-Li Wei, 2012. "Effect of Intravitreal Anti-Vascular Endothelial Growth Factor Therapy on the Risk of Arterial Thromboembolic Events: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
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    1. Ulrika Sjöbom & Anders K Nilsson & Hanna Gyllensten & Ann Hellström & Chatarina Löfqvist, 2022. "A systematic review and meta-analysis of preanalytical factors and methodological differences influencing the measurement of circulating vascular endothelial growth factor," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-31, July.
    2. Qing-Qing Tan & Stephen P Christiansen & Jingyun Wang, 2019. "Development of refractive error in children treated for retinopathy of prematurity with anti-vascular endothelial growth factor (anti-VEGF) agents: A meta-analysis and systematic review," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-18, December.

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