IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0084855.html

Effects of Anabolic Steroids on Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomised Controlled Trials

Author

Listed:
  • Lei Pan
  • Manyuan Wang
  • Xiaomei Xie
  • Changjun Du
  • Yongzhong Guo

Abstract

Background: Anabolic steroids are known to improve body composition and muscle strength in healthy people. However, whether anabolic steroids improve the physical condition and function in patients with chronic obstructive pulmonary disease (COPD) remains undetermined. A meta-analysis was conducted to review the current evidence regarding the effects of anabolic steroids on COPD patients. Methods: A comprehensive literature search of PubMed and EMBASE was performed to identify randomised controlled trials that examine the effects of anabolic steroids on COPD patients. Weighted mean differences (WMDs) with 95% confidence intervals were calculated to determine differences between anabolic steroid administration and control conditions. Results: Eight eligible studies involving 273 COPD patients were identified in this meta-analysis. Significant improvements were found in body weight (0.956 kg), fat-free mass (1.606 kg), St. George's Respiratory Questionnaire total score (−6.336) and symptom score (−12.148). The apparent improvements in maximal inspiratory pressure (2.740 cmH2O) and maximal expiratory pressure (12.679 cmH2O) were not significant. The effects on handgrip strength, forced expiratory volume in one second (FEV1), predicted FEV1 percent, PaO2, PaCO2 and six-min walk distance were negative, with WMDs of −0.245 kg, −0.096 L/sec, −1.996% of predicted, −1.648 cmHg, −0.039 cmHg and −16.102 meters, respectively. Conclusions: Limited evidence available from the published literature suggests that the benefit of anabolic steroids on COPD patients cannot be denied. However, further studies are needed to identify the specific benefits and adverse effects of anabolic steroids on COPD patients and to determine the optimal populations and regimes of anabolic steroids in COPD patients.

Suggested Citation

  • Lei Pan & Manyuan Wang & Xiaomei Xie & Changjun Du & Yongzhong Guo, 2014. "Effects of Anabolic Steroids on Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomised Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0084855
    DOI: 10.1371/journal.pone.0084855
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084855
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084855&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0084855?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jun-Hong Yan & Yong-Zhong Guo & Hong-Mei Yao & Lei Pan, 2013. "Effects of Tai Chi in Patients with Chronic Obstructive Pulmonary Disease: Preliminary Evidence," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Milena Dalton & Benjamin Sanderson & Leanne J Robinson & Caroline S E Homer & William Pomat & Margie Danchin & Stefanie Vaccher, 2023. "Impact of COVID-19 on routine childhood immunisations in low- and middle-income countries: A scoping review," PLOS Global Public Health, Public Library of Science, vol. 3(8), pages 1-17, August.
    2. Ludoviko Zirimenya & Fatima Mahmud-Ajeigbe & Ruth McQuillan & You Li, 2020. "A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(6), pages 1-13, June.
    3. Desalegne Amare & Fentie Ambaw Getahun & Endalkachew Worku Mengesha & Getenet Dessie & Melashu Balew Shiferaw & Tegenaw Asemamaw Dires & Kefyalew Addis Alene, 2023. "Effectiveness of healthcare workers and volunteers training on improving tuberculosis case detection: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(3), pages 1-13, March.
    4. Trang Nguyen & Sara Holton & Thach Tran & Jane Fisher, 2019. "Informal mental health interventions for people with severe mental illness in low and lower middle-income countries: A systematic review of effectiveness," International Journal of Social Psychiatry, , vol. 65(3), pages 194-206, May.
    5. Cocco, Edoardo & Hashimoto, Yuji Z. & Chopin, Julien, 2025. "Child sexual abuse in the catholic church: A scoping review of characteristics, prevalence, and explanatory factors," Journal of Criminal Justice, Elsevier, vol. 101(C).
    6. Alessandro Concari & Gerjo Kok & Pim Martens, 2020. "A Systematic Literature Review of Concepts and Factors Related to Pro-Environmental Consumer Behaviour in Relation to Waste Management Through an Interdisciplinary Approach," Sustainability, MDPI, vol. 12(11), pages 1-50, May.
    7. Damiano Pizzol & Mike Trott & Igor Grabovac & Mario Antunes & Anna Claudia Colangelo & Simona Ippoliti & Cristian Petre Ilie & Anne Carrie & Nicola Veronese & Lee Smith, 2021. "Laparoscopy in Low-Income Countries: 10-Year Experience and Systematic Literature Review," IJERPH, MDPI, vol. 18(11), pages 1-11, May.
    8. repec:plo:pone00:0215221 is not listed on IDEAS
    9. repec:plo:pone00:0214746 is not listed on IDEAS
    10. Alessandro Margherita & Emanuele Banchi & Alfredo Biffi & Gianluca di Castri & Rocco Morelli, 2022. "Beyond Total Cost Management (TCM) to Systemic Value Management (SVM): Transformational Trends and a Research Manifesto for an Evolving Discipline," Sustainability, MDPI, vol. 14(19), pages 1-16, October.
    11. Stefano D’Angelo & Angelo Cavallo & Antonio Ghezzi & Francesco Di Lorenzo, 2024. "Understanding corporate entrepreneurship in the digital age: a review and research agenda," Review of Managerial Science, Springer, vol. 18(12), pages 3719-3774, December.
    12. Fabio Magnacca & Riccardo Giannetti, 2024. "Management accounting and new product development: a systematic literature review and future research directions," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 28(2), pages 651-685, June.
    13. repec:plo:pone00:0178295 is not listed on IDEAS
    14. Evans, Rhiannon & White, James & Turley, Ruth & Slater, Thomas & Morgan, Helen & Strange, Heather & Scourfield, Jonathan, 2017. "Comparison of suicidal ideation, suicide attempt and suicide in children and young people in care and non-care populations: Systematic review and meta-analysis of prevalence," Children and Youth Services Review, Elsevier, vol. 82(C), pages 122-129.
    15. Arjun K Reddy & Jared T Scott & Grayson R Norris & Chip Moore & Jake X Checketts & Griffin K Hughes & Travis Small & Mark M Calder & Brent L Norris, 2023. "Cemented vs Uncemented hemiarthroplasties for femoral neck fractures: An overlapping systematic review and evidence appraisal," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-18, February.
    16. Hang-Nga Mai & Jaeil Kim & Youn-Hee Choi & Du-Hyeong Lee, 2020. "Accuracy of Portable Face-Scanning Devices for Obtaining Three-Dimensional Face Models: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(1), pages 1-15, December.
    17. D. L. I. H. K. Peiris & Yanping Duan & Corneel Vandelanotte & Wei Liang & Min Yang & Julien Steven Baker, 2022. "Effects of In-Classroom Physical Activity Breaks on Children’s Academic Performance, Cognition, Health Behaviours and Health Outcomes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials," IJERPH, MDPI, vol. 19(15), pages 1-27, August.
    18. Stephanie Kovacs & Stephen E Hawes & Stephen N Maley & Emily Mosites & Ling Wong & Andy Stergachis, 2014. "Technologies for Detecting Falsified and Substandard Drugs in Low and Middle-Income Countries," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    19. Najmiatul Fitria & Antoinette D. I. Asselt & Maarten J. Postma, 2019. "Cost-effectiveness of controlling gestational diabetes mellitus: a systematic review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(3), pages 407-417, April.
    20. Hyun Woo Lee & Jung Kyu Lee & Eunyoung Kim & Jae-Joon Yim & Chang-Hoon Lee, 2016. "The Effectiveness and Safety of Fluoroquinolone-Containing Regimen as a First-Line Treatment for Drug-Sensitive Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-15, July.
    21. Jung Soo Kim & Jinkyeong Park & Seong Yong Lim & Yeon-Mok Oh & Kwang Ha Yoo & Yong Bum Park & Seung Soo Sheen & Min-Ji Kim & K C Carriere & Ji Ye Jung & Hye Yun Park, 2015. "Comparison of Clinical Efficacy and Safety between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-12, March.
    22. Giuseppe La Torre & Remigio Bova & Rosario Andrea Cocchiara & Cristina Sestili & Anna Tagliaferri & Simona Maggiacomo & Camilla Foschi & William Zomparelli & Maria Vittoria Manai & David Shaholli & Va, 2023. "What Are the Determinants of the Quality of Systematic Reviews in the International Journals of Occupational Medicine? A Methodological Study Review of Published Literature," IJERPH, MDPI, vol. 20(2), pages 1-12, January.
    23. Eric P F Chow & Joseph D Tucker & Frank Y Wong & Eric J Nehl & Yanjie Wang & Xun Zhuang & Lei Zhang, 2014. "Disparities and Risks of Sexually Transmissible Infections among Men Who Have Sex with Men in China: A Meta-Analysis and Data Synthesis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-13, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0084855. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.