Surveillance of Dengue Fever Virus: A Review of Epidemiological Models and Early Warning Systems

Dengue fever affects over a 100 million people annually hence is one of the world's most important vector-borne diseases. The transmission area of this disease continues to expand due to many direct and indirect factors linked to urban sprawl, increased travel and global warming. Current preventative measures include mosquito control programs, yet due to the complex nature of the disease and the increased importation risk along with the lack of efficient prophylactic measures, successful disease control and elimination is not realistic in the foreseeable future. Epidemiological models attempt to predict future outbreaks using information on the risk factors of the disease. Through a systematic literature review, this paper aims at analyzing the different modeling methods and their outputs in terms of acting as an early warning system. We found that many previous studies have not sufficiently accounted for the spatio-temporal features of the disease in the modeling process. Yet with advances in technology, the ability to incorporate such information as well as the socio-environmental aspect allowed for its use as an early warning system, albeit limited geographically to a local scale. Author Summary: Despite mass vaccination campaigns and large scaled improvements in global surveillance, infectious diseases are a worldwide problem. In recent years, the ability to use models as a tool to help visualize, understand and combat infectious diseases has become more feasible and reliable. In this context, modelling focuses on transmission patterns between the different animal, human or vector components as well as including parameters which affect these pathways such as environmental, climatic or geographic ones. The output of these models can help in decision making processes concerning control purposes, surveillance methods and hopefully also as good predictive tools. Prediction forms part of surveillance systems, and more specifically in early warning systems. It is the timely collection and analysis of data as well as the use of risk-based assessments in order to aid in prompt health interventions such as movement control, vaccination campaigns or the distribution of important information. Early warning systems for vector borne diseases are especially complex due to the involvement of various factors originating from the human, animal and insect sector as well the disease itself. The authors investigate the variety and depth of available models for dengue fever surveillance and their use as early warning tools.