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The Sex Inclusive Research Framework to address sex bias in preclinical research proposals

Author

Listed:
  • Natasha A. Karp

    (AstraZeneca)

  • Manuel Berdoy

    (University of Oxford)

  • Kelly Gray

    (AstraZeneca)

  • Lilian Hunt

    (Wellcome Trust)

  • Maggy Jennings

    (Animals in Science Department)

  • Angela Kerton

    (The Learning Curve (Development) Ltd)

  • Matt Leach

    (Newcastle University)

  • Jordi L. Tremoleda

    (Queen Mary University of London)

  • Jon Gledhill

    (Newcastle University)

  • Esther J. Pearl

    (The NC3Rs)

  • Nathalie Percie du Sert

    (The NC3Rs)

  • Benjamin Phillips

    (AstraZeneca)

  • Penny S. Reynolds

    (University of Florida)

  • Kathy Ryder

    (Stormont Estate)

  • S. Clare Stanford

    (University College London)

  • Sara Wells

    (Harwell Science and Innovation Campus
    The Francis Crick Institute)

  • Lucy Whitfield

    (OWL Vets Ltd)

Abstract

An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex vivo research proposals to address the risk of sex bias in preclinical research. The framework delivers a traffic light classification, indicating whether a proposal is appropriate, risky, or insufficient with regard to sex inclusion. This tool is designed for use by researchers, (animal) ethical review boards, and funders to generate a rigorous and reproducible assessment of sex inclusion at the proposal level, thus helping address and resolve the embedded sex bias in preclinical research.

Suggested Citation

  • Natasha A. Karp & Manuel Berdoy & Kelly Gray & Lilian Hunt & Maggy Jennings & Angela Kerton & Matt Leach & Jordi L. Tremoleda & Jon Gledhill & Esther J. Pearl & Nathalie Percie du Sert & Benjamin Phil, 2025. "The Sex Inclusive Research Framework to address sex bias in preclinical research proposals," Nature Communications, Nature, vol. 16(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58560-5
    DOI: 10.1038/s41467-025-58560-5
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