IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-57647-3.html
   My bibliography  Save this article

Portable molecular diagnostic platform for rapid point-of-care detection of mpox and other diseases

Author

Listed:
  • Matthew L. Cavuto

    (Imperial College London
    Imperial College London)

  • Kenny Malpartida-Cardenas

    (Imperial College London
    Imperial College London)

  • Ivana Pennisi

    (Imperial College London
    Imperial College London)

  • Marcus J. Pond

    (Imperial College Healthcare NHS Trust)

  • Sohail Mirza

    (Imperial College London
    Imperial College London)

  • Nicolas Moser

    (Imperial College London
    Imperial College London)

  • Mark Comer

    (Imperial College London)

  • Isobel Stokes

    (University of Surrey)

  • Lucy Eke

    (University of Surrey)

  • Sian Lant

    (University of Surrey)

  • Katarzyna M. Szostak-Lipowicz

    (Imperial College London)

  • Luca Miglietta

    (Imperial College London)

  • Oliver W. Stringer

    (Imperial College London
    Imperial College London)

  • Katerina-Theresa Mantikas

    (Imperial College London
    Imperial College London)

  • Rebecca P. Sumner

    (University of Surrey)

  • Frances Bolt

    (Imperial College London
    Imperial College London)

  • Shiranee Sriskandan

    (Imperial College London
    Imperial College London)

  • Alison Holmes

    (Imperial College London
    University of Liverpool
    Imperial College London and Imperial College Healthcare NHS Trust)

  • Pantelis Georgiou

    (Imperial College London
    Imperial College London)

  • David O. Ulaeto

    (Defence Science and Technology Laboratory)

  • Carlos Maluquer de Motes

    (University of Surrey)

  • Jesus Rodriguez-Manzano

    (Imperial College London
    Imperial College London)

Abstract

The World Health Organization’s designation of mpox as a public health emergency of international concern in August 2024 underscores the urgent need for effective diagnostic solutions to combat this escalating threat. The rapid global spread of clade II mpox, coupled with the sustained human-to-human transmission of the more virulent clade I mpox in the Democratic Republic of Congo, highlights a critical gap in point-of-care diagnostics for this emergent disease. In response, we developed Dragonfly, a portable molecular diagnostic platform for point-of-care use that integrates power-free nucleic acid extraction (

Suggested Citation

  • Matthew L. Cavuto & Kenny Malpartida-Cardenas & Ivana Pennisi & Marcus J. Pond & Sohail Mirza & Nicolas Moser & Mark Comer & Isobel Stokes & Lucy Eke & Sian Lant & Katarzyna M. Szostak-Lipowicz & Luca, 2025. "Portable molecular diagnostic platform for rapid point-of-care detection of mpox and other diseases," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57647-3
    DOI: 10.1038/s41467-025-57647-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-57647-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-57647-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. David M. Morens & Gregory K. Folkers & Anthony S. Fauci, 2004. "The challenge of emerging and re-emerging infectious diseases," Nature, Nature, vol. 430(6996), pages 242-249, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. John M Drake & Tobias S Brett & Shiyang Chen & Bogdan I Epureanu & Matthew J Ferrari & Éric Marty & Paige B Miller & Eamon B O’Dea & Suzanne M O’Regan & Andrew W Park & Pejman Rohani, 2019. "The statistics of epidemic transitions," PLOS Computational Biology, Public Library of Science, vol. 15(5), pages 1-14, May.
    2. Moshe B Hoshen & Anthony H Burton & Themis J V Bowcock, 2007. "Simulating disease transmission dynamics at a multi-scale level," International Journal of Microsimulation, International Microsimulation Association, vol. 1(1), pages 26-34.
    3. Ivan Montiel & Junghoon Park & Bryan W. Husted & Andres Velez-Calle, 2022. "Tracing the connections between international business and communicable diseases," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 53(8), pages 1785-1804, October.
    4. repec:plo:pmed00:1000272 is not listed on IDEAS
    5. Deqiao Tian & Tao Zheng, 2015. "Emerging infectious disease: trends in the literature on SARS and H7N9 influenza," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(1), pages 485-495, October.
    6. Li, Sen & Vanwambeke, Sophie O. & Licoppe, Alain M. & Speybroeck, Niko, 2014. "Impacts of deer management practices on the spatial dynamics of the tick Ixodes ricinus: A scenario analysis," Ecological Modelling, Elsevier, vol. 276(C), pages 1-13.
    7. Vinyas Harish & Felipe J. Colón-González & Filipe R. R. Moreira & Rory Gibb & Moritz U. G. Kraemer & Megan Davis & Robert C. Reiner & David M. Pigott & T. Alex Perkins & Daniel J. Weiss & Isaac I. Bog, 2024. "Human movement and environmental barriers shape the emergence of dengue," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    8. Kow-Tong Chen, 2022. "Emerging Infectious Diseases and One Health: Implication for Public Health," IJERPH, MDPI, vol. 19(15), pages 1-4, July.
    9. Shujuan Li & Lingli Zhu & Lidan Zhang & Guoyan Zhang & Hongyan Ren & Liang Lu, 2023. "Urbanization-Related Environmental Factors and Hemorrhagic Fever with Renal Syndrome: A Review Based on Studies Taken in China," IJERPH, MDPI, vol. 20(4), pages 1-20, February.
    10. repec:plo:pcbi00:1003587 is not listed on IDEAS
    11. Adetayo Olaniyi Adeniran & Samuel Oluwaseyi Olorunfemi & Feyisola Olajire Akinsehinwa & Taye Mohammed Abdullahi, 2021. "Nexus between urban mobility and the transmission of infectious diseases: evidence from empirical review," Post-Print hal-03583997, HAL.
    12. repec:plo:pone00:0086591 is not listed on IDEAS
    13. Zhang, Zehui & Zhu, Kangci & Wang, Fang, 2025. "Indirect information propagation model with time-delay effect on multiplex networks," Chaos, Solitons & Fractals, Elsevier, vol. 192(C).
    14. Nuur Hafizah Md Iderus & Sarbhan Singh Lakha Singh & Sumarni Mohd Ghazali & Cheong Yoon Ling & Tan Cia Vei & Ahmed Syahmi Syafiq Md Zamri & Nadhar Ahmad Jaafar & Qistina Ruslan & Nur Huda Ahmad Jaghfa, 2022. "Correlation between Population Density and COVID-19 Cases during the Third Wave in Malaysia: Effect of the Delta Variant," IJERPH, MDPI, vol. 19(12), pages 1-17, June.
    15. Xiaotong Wen & Feiyu Chen & Yixiang Lin & Hui Zhu & Fang Yuan & Duyi Kuang & Zhihui Jia & Zhaokang Yuan, 2020. "Microbial Indicators and Their Use for Monitoring Drinking Water Quality—A Review," Sustainability, MDPI, vol. 12(6), pages 1-14, March.
    16. repec:plo:pone00:0014140 is not listed on IDEAS
    17. Deqiao Tian & Yunzhou Yu & Yumin Wang & Tao Zheng, 2012. "Comparison of trends in the quantity and variety of Science Citation Index (SCI) literature on human pathogens between China and the United States," Scientometrics, Springer;Akadémiai Kiadó, vol. 93(3), pages 1019-1027, December.
    18. Huo, Liang’an & Yu, Yue, 2023. "The impact of the self-recognition ability and physical quality on coupled negative information-behavior-epidemic dynamics in multiplex networks," Chaos, Solitons & Fractals, Elsevier, vol. 169(C).
    19. Ascioti, Fortunato A. & Mangano, Maria Cristina & Marcianò, Claudio & Sarà, Gianluca, 2022. "The sanitation service of seagrasses – Dependencies and implications for the estimation of avoided costs," Ecosystem Services, Elsevier, vol. 54(C).
    20. Hui-Yi Yeh & Kou-Huang Chen & Kow-Tong Chen, 2018. "Environmental Determinants of Infectious Disease Transmission: A Focus on One Health Concept," IJERPH, MDPI, vol. 15(6), pages 1-3, June.
    21. Nicodemo, Catia & Barzin, Samira & Lasserson, Daniel S. & Moscone, Francesco & Redding, Stuart & Shaikh, Mujaheed & Cavalli, Nicolò, 2020. "Measuring Geographical Disparities in England at the Time of COVID-19: Results Using a Composite Indicator of Population Vulnerability," IZA Discussion Papers 13757, Institute of Labor Economics (IZA).
    22. Wolfgang Brozek & Christof Falkenberg, 2021. "Industrial Animal Farming and Zoonotic Risk: COVID-19 as a Gateway to Sustainable Change? A Scoping Study," Sustainability, MDPI, vol. 13(16), pages 1-30, August.
    23. Hu, Xin & Wang, Zhishuang & Sun, Qingyi & Chen, Jiaxing & Zhao, Dawei & Xia, Chengyi, 2024. "Coupled propagation between one communicable disease and related two types of information on multiplex networks with simplicial complexes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 645(C).
    24. Mutsaers, Inge, 2015. "One-health approach as counter-measure against “autoimmune” responses in biosecurity," Social Science & Medicine, Elsevier, vol. 129(C), pages 123-130.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57647-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.