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Mnemonic construction and representation of temporal structure in the hippocampal formation

Author

Listed:
  • Jacob L. S. Bellmund

    (Max Planck Institute for Human Cognitive and Brain Sciences)

  • Lorena Deuker

    (Radboud University)

  • Nicole D. Montijn

    (Utrecht University)

  • Christian F. Doeller

    (Max Planck Institute for Human Cognitive and Brain Sciences
    Norwegian University of Science and Technology
    Leipzig University)

Abstract

The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.

Suggested Citation

  • Jacob L. S. Bellmund & Lorena Deuker & Nicole D. Montijn & Christian F. Doeller, 2022. "Mnemonic construction and representation of temporal structure in the hippocampal formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30984-3
    DOI: 10.1038/s41467-022-30984-3
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    References listed on IDEAS

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    Cited by:

    1. Futing Zou & Guo Wanjia & Emily J. Allen & Yihan Wu & Ian Charest & Thomas Naselaris & Kendrick Kay & Brice A. Kuhl & J. Benjamin Hutchinson & Sarah DuBrow, 2023. "Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Jordan Crivelli-Decker & Alex Clarke & Seongmin A. Park & Derek J. Huffman & Erie D. Boorman & Charan Ranganath, 2023. "Goal-oriented representations in the human hippocampus during planning and navigation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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