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Time-dependent memory transformation in hippocampus and neocortex is semantic in nature

Author

Listed:
  • Valentina Krenz

    (Universität Hamburg)

  • Arjen Alink

    (Universität Hamburg
    University Medical Centre Hamburg-Eppendorf)

  • Tobias Sommer

    (University Medical Centre Hamburg-Eppendorf)

  • Benno Roozendaal

    (Radboud University Medical Center
    Radboud University)

  • Lars Schwabe

    (Universität Hamburg)

Abstract

Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.

Suggested Citation

  • Valentina Krenz & Arjen Alink & Tobias Sommer & Benno Roozendaal & Lars Schwabe, 2023. "Time-dependent memory transformation in hippocampus and neocortex is semantic in nature," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41648-1
    DOI: 10.1038/s41467-023-41648-1
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    References listed on IDEAS

    as
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    2. Valentina Krenz & Tobias Sommer & Arjen Alink & Benno Roozendaal & Lars Schwabe, 2021. "Noradrenergic arousal after encoding reverses the course of systems consolidation in humans," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
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    4. Lisa C. Dandolo & Lars Schwabe, 2018. "Time-dependent memory transformation along the hippocampal anterior–posterior axis," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    5. Hamed Nili & Cai Wingfield & Alexander Walther & Li Su & William Marslen-Wilson & Nikolaus Kriegeskorte, 2014. "A Toolbox for Representational Similarity Analysis," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-11, April.
    Full references (including those not matched with items on IDEAS)

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