IDEAS home Printed from https://ideas.repec.org/a/inm/ormnsc/v50y2004i10p1420-1430.html
   My bibliography  Save this article

The Optimal Timing of Living-Donor Liver Transplantation

Author

Listed:
  • Oguzhan Alagoz

    () (Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261)

  • Lisa M. Maillart

    () (Weatherhead School of Management, Case Western Reserve University, Cleveland, Ohio 44106)

  • Andrew J. Schaefer

    () (Departments of Industrial Engineering and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261)

  • Mark S. Roberts

    () (Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213)

Abstract

Living donors are a significant and increasing source of livers for transplantation, mainly because of the insufficient supply of cadaveric organs. We consider the problem of optimally timing a living-donor liver transplant to maximize the patient's total reward, such as quality-adjusted life expectancy. We formulate a Markov decision process (MDP) model in which the state of the process is described by patient health. We derive structural properties of the MDP model, including a set of intuitive conditions that ensure the existence of a control-limit optimal policy. We use clinical data in our computational experiments, which show that the optimal policy is typically of control-limit type.

Suggested Citation

  • Oguzhan Alagoz & Lisa M. Maillart & Andrew J. Schaefer & Mark S. Roberts, 2004. "The Optimal Timing of Living-Donor Liver Transplantation," Management Science, INFORMS, vol. 50(10), pages 1420-1430, October.
  • Handle: RePEc:inm:ormnsc:v:50:y:2004:i:10:p:1420-1430
    as

    Download full text from publisher

    File URL: http://dx.doi.org/10.1287/mnsc.1040.0287
    Download Restriction: no

    References listed on IDEAS

    as
    1. Chen, Mingchih & Feldman, Richard M., 1997. "Optimal replacement policies with minimal repair and age-dependent costs," European Journal of Operational Research, Elsevier, vol. 98(1), pages 75-84, April.
    2. Howard, David H., 2002. "Why do transplant surgeons turn down organs?: A model of the accept/reject decision," Journal of Health Economics, Elsevier, vol. 21(6), pages 957-969, November.
    3. Howard J. Weiss, 1979. "The Computation of Optimal Control Limits for a Queue with Batch Services," Management Science, INFORMS, vol. 25(4), pages 320-328, April.
    4. Chew, Soo Hong & Ho, Joanna L, 1994. "Hope: An Empirical Study of Attitude toward the Timing of Uncertainty Resolution," Journal of Risk and Uncertainty, Springer, vol. 8(3), pages 267-288, May.
    5. Jae-Hyeon Ahn & John C. Hornberger, 1996. "Involving Patients in the Cadaveric Kidney Transplant Allocation Process: A Decision-Theoretic Perspective," Management Science, INFORMS, vol. 42(5), pages 629-641, May.
    6. Cyrus Derman, 1963. "Optimal Replacement and Maintenance Under Markovian Deterioration with Probability Bounds on Failure," Management Science, INFORMS, vol. 9(3), pages 478-481, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Caulkins, Jonathan P., 2010. "Might randomization in queue discipline be useful when waiting cost is a concave function of waiting time?," Socio-Economic Planning Sciences, Elsevier, vol. 44(1), pages 19-24, March.
    2. repec:pal:jorsoc:v:68:y:2017:i:9:d:10.1057_s41274-017-0219-2 is not listed on IDEAS
    3. Paarsch, Harry J. & Segre, Alberto M. & Roberts, John P. & Halldorson, Jeffrey B., 2011. "Competition and Post-Transplant Outcomes in Cadaveric Liver Transplantation under the MELD Scoring System," CIS Discussion paper series 522, Center for Intergenerational Studies, Institute of Economic Research, Hitotsubashi University.
    4. Mason, J.E. & Denton, B.T. & Shah, N.D. & Smith, S.A., 2014. "Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients," European Journal of Operational Research, Elsevier, vol. 233(3), pages 727-738.
    5. Oguzhan Alagoz & Lisa M. Maillart & Andrew J. Schaefer & Mark S. Roberts, 2007. "Choosing Among Living-Donor and Cadaveric Livers," Management Science, INFORMS, vol. 53(11), pages 1702-1715, November.
    6. Jingyu Zhang & Brian T. Denton & Hari Balasubramanian & Nilay D. Shah & Brant A. Inman, 2012. "Optimization of Prostate Biopsy Referral Decisions," Manufacturing & Service Operations Management, INFORMS, vol. 14(4), pages 529-547, October.
    7. Ching-Feng Lin & Aera LeBoulluec & Li Zeng & Victoria Chen & Robert Gatchel, 2014. "A decision-making framework for adaptive pain management," Health Care Management Science, Springer, vol. 17(3), pages 270-283, September.
    8. Kang, Yuncheol & Sawyer, Amy M. & Griffin, Paul M. & Prabhu, Vittaldas V., 2016. "Modelling adherence behaviour for the treatment of obstructive sleep apnoea," European Journal of Operational Research, Elsevier, vol. 249(3), pages 1005-1013.
    9. Nan Kong & Andrew J. Schaefer & Brady Hunsaker & Mark S. Roberts, 2010. "Maximizing the Efficiency of the U.S. Liver Allocation System Through Region Design," Management Science, INFORMS, vol. 56(12), pages 2111-2122, December.
    10. repec:kap:hcarem:v:20:y:2017:i:2:d:10.1007_s10729-015-9347-x is not listed on IDEAS
    11. Baruch Keren & Joseph Pliskin, 2011. "Optimal timing of joint replacement using mathematical programming and stochastic programming models," Health Care Management Science, Springer, vol. 14(4), pages 361-369, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:inm:ormnsc:v:50:y:2004:i:10:p:1420-1430. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Mirko Janc). General contact details of provider: http://edirc.repec.org/data/inforea.html .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.