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Residential Segregation and Epigenetic Age Acceleration Among Older-Age Black and White Americans

Author

Listed:
  • Reed DeAngelis

    (Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA)

  • Victoria Fisher

    (College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA)

  • John Dou

    (Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA)

  • Kelly Bakulski

    (Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA)

  • David Rigby

    (Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA)

  • Margaret Hicken

    (Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA)

Abstract

Our study tests residential segregation as an explanation for biological aging disparities between Black and White Americans. We analyze data from 288 Black and White older-age adults who participated in Wave 6 (2019) of the Americans’ Changing Lives study, a nationally representative cohort of adults in the contiguous United States. Our outcome of interest is epigenetic age acceleration assessed via five epigenetic clocks: GrimAge, PhenoAge, SkinBloodAge, HannumAge, and HorvathAge. Residential segregation is operationalized at the census tract level using the Getis-Ord G i * statistic and multilevel modeling procedures that adjust for state-level clustering. We uncover three key findings. First, epigenetic age profiles are comparable among White respondents regardless of where they live. Second, Black respondents express roughly three years of accelerated epigenetic age (GrimAge), relative to White counterparts, regardless of where they live. Third, diminished education levels and homeownership rates, coupled with elevated levels of traumatic stress and smoking, explain why Black residents in segregated Black areas exhibit accelerated epigenetic age. However, these factors do not explain why Black respondents living outside segregated Black areas also exhibit epigenetic age acceleration. Our findings suggest residential segregation only partially explains why Black Americans tend to live shorter lives than White Americans.

Suggested Citation

  • Reed DeAngelis & Victoria Fisher & John Dou & Kelly Bakulski & David Rigby & Margaret Hicken, 2025. "Residential Segregation and Epigenetic Age Acceleration Among Older-Age Black and White Americans," IJERPH, MDPI, vol. 22(6), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:6:p:837-:d:1665199
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    References listed on IDEAS

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    1. Raj Chetty & Nathaniel Hendren & Maggie R Jones & Sonya R Porter, 2020. "Race and Economic Opportunity in the United States: an Intergenerational Perspective [“Intergenerational Mobility of Immigrants in the US Over Two Centuries,”]," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 135(2), pages 711-783.
    2. Hicken, Margaret T. & Kravitz-Wirtz, Nicole & Durkee, Myles & Jackson, James S., 2018. "Racial inequalities in health: Framing future research," Social Science & Medicine, Elsevier, vol. 199(C), pages 11-18.
    3. Graetz, Nick & Gershenson, Carl & Porter, Sonya R. & Sandler, Danielle H. & Lemmerman, Emily & Desmond, Matthew, 2024. "The impacts of rent burden and eviction on mortality in the United States, 2000–2019," Social Science & Medicine, Elsevier, vol. 340(C).
    4. Eun Young Choi & Jennifer A Ailshire & Kenzie Latham-Mintus, 2024. "Neighborhood Stressors and Epigenetic Age Acceleration Among Older Americans," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 79(12), pages 16-29.
    5. Crimmins, Eileen M. & Saito, Yasuhiko, 2001. "Trends in healthy life expectancy in the United States, 1970-1990: gender, racial, and educational differences," Social Science & Medicine, Elsevier, vol. 52(11), pages 1629-1641, June.
    6. Hamed Nilforoshan & Wenli Looi & Emma Pierson & Blanca Villanueva & Nic Fishman & Yiling Chen & John Sholar & Beth Redbird & David Grusky & Jure Leskovec, 2023. "Human mobility networks reveal increased segregation in large cities," Nature, Nature, vol. 624(7992), pages 586-592, December.
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