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The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis

Author

Listed:
  • Huojie Yao

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China
    These authors contributed equally to this work.)

  • Yingyin Fu

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China
    These authors contributed equally to this work.)

  • Xueqiong Weng

    (Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
    These authors contributed equally to this work.)

  • Zurui Zeng

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Yuxuan Tan

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Xiaomei Wu

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Huixian Zeng

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Zhiyu Yang

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Yexin Li

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Huanzhu Liang

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Yingying Wu

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Lin Wen

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China)

  • Chunxia Jing

    (Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China
    Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, China)

Abstract

Exposure to per- and polyfluoroalkyl substances (PFAS) during pregnancy has been suggested to be associated with neurobehavioral problems in offspring. However, current epidemiological studies on the association between prenatal PFAS exposure and neurobehavioral problems among offspring, especially attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are inconsistent. Therefore, we aimed to study the relationship between PFAS exposure during pregnancy and ADHD and ASD in offspring based on meta-analyses. Online databases, including PubMed, EMBASE, and Web of Science, were searched comprehensively for eligible studies conducted before July 2021. Eleven studies (up to 8493 participants) were included in this analysis. The pooled results demonstrated that exposure to perfluorooctanoate (PFOA) was positively associated with ADHD in the highest quartile group. Negative associations were observed between perfluorooctane sulfonate (PFOS) and ADHD/ASD, including between perfluorononanoate (PFNA) and ASD. There were no associations found between total PFAS concentration groups and neurobehavioral problems. The trial sequential analyses showed unstable results. Our findings indicated that PFOA and PFOS exposure during pregnancy might be associated with ADHD in offspring and that prenatal PFOS and PFNA exposure might be associated with ASD in offspring. According to the limited evidence obtained for most associations, additional studies are required to validate these findings.

Suggested Citation

  • Huojie Yao & Yingyin Fu & Xueqiong Weng & Zurui Zeng & Yuxuan Tan & Xiaomei Wu & Huixian Zeng & Zhiyu Yang & Yexin Li & Huanzhu Liang & Yingying Wu & Lin Wen & Chunxia Jing, 2023. "The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis," IJERPH, MDPI, vol. 20(3), pages 1-16, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:3:p:1668-:d:1038557
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    References listed on IDEAS

    as
    1. David Trudel & Lea Horowitz & Matthias Wormuth & Martin Scheringer & Ian T. Cousins & Konrad Hungerbühler, 2008. "Estimating Consumer Exposure to PFOS and PFOA," Risk Analysis, John Wiley & Sons, vol. 28(2), pages 251-269, April.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    3. Ilona Quaak & Marijke De Cock & Michiel De Boer & Marja Lamoree & Pim Leonards & Margot Van de Bor, 2016. "Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children," IJERPH, MDPI, vol. 13(5), pages 1-20, May.
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    Keywords

    PFAS; ADHD; ASD; pregnancy; offspring;
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