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Impact of Pharmacists-Led Interventions in Primary Care for Adults with Type 2 Diabetes on HbA1c Levels: A Systematic Review and Meta-Analysis

Author

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  • Claire Coutureau

    (Department of Research and Public Health, Reims University Hospital, 51092 Reims, France
    UR 3797 Vieillissement, Fragilité (VieFra), Faculty of Medicine, University of Reims Champagne-Ardenne, 51092 Reims, France)

  • Florian Slimano

    (Department of Pharmacy, Reims University Hospital, 51092 Reims, France)

  • Céline Mongaret

    (Department of Pharmacy, Reims University Hospital, 51092 Reims, France)

  • Lukshe Kanagaratnam

    (Department of Research and Public Health, Reims University Hospital, 51092 Reims, France
    UR 3797 Vieillissement, Fragilité (VieFra), Faculty of Medicine, University of Reims Champagne-Ardenne, 51092 Reims, France)

Abstract

Type 2 diabetes mellitus (T2D) is responsible for an important premature mortality. Pharmacists involved in community-based pharmaceutical care services could help patients with diabetes through education and management as they participate in their regular and long-term care. This meta-analysis aimed to evaluate the association between interventions led by pharmacists in the primary care setting and mean change in HbA1c levels. Randomized controlled trials and quasi-experimental studies with a control group were included. Standardized mean differences (SMD) and their 95% confidence intervals (95% CI) were calculated to compare the mean change in HbA1c values between baseline and end of the intervention in each group. Subgroup analyses were performed to explore heterogeneity. Twelve articles were included. The results showed that pharmacist’s interventions significantly reduced HbA1c compared to usual care with an overall SMD of −0.67 (95% CI = [−0.87; −0.48], p < 0.0001). Even if no significant difference between subgroups were found, the reduction of HbA1c seemed more important when baseline HbA1c was ≥8.5%, the intervention occurred monthly, in a primary care center and in countries with a lower human development index. Our results suggest that pharmacists-led interventions in the primary care setting can improve glycemic control for adults with T2D.

Suggested Citation

  • Claire Coutureau & Florian Slimano & Céline Mongaret & Lukshe Kanagaratnam, 2022. "Impact of Pharmacists-Led Interventions in Primary Care for Adults with Type 2 Diabetes on HbA1c Levels: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(6), pages 1-20, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3156-:d:766198
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    References listed on IDEAS

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    2. Mossialos, Elias & Courtin, Emilie & Naci, Huseyin & Benrimoj, Shalom & Bouvy, Marcel & Farris, Karen & Noyce, Peter & Sketris, Ingrid, 2015. "From “retailers” to health care providers: Transforming the role of community pharmacists in chronic disease management," Health Policy, Elsevier, vol. 119(5), pages 628-639.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Sarah Al Assaf & Romana Zelko & Balazs Hanko, 2022. "The Effect of Interventions Led by Community Pharmacists in Primary Care for Adults with Type 2 Diabetes Mellitus on Therapeutic Adherence and HbA1c Levels: A Systematic Review," IJERPH, MDPI, vol. 19(10), pages 1-16, May.

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