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Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage

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  • Jonatan A. Mendoza-Ortega

    (Immunobiochemistry Department, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico
    Innate Immunology Laboratory, Immunology Department, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, Mexico City 11350, Mexico)

  • Enrique Reyes-Muñoz

    (Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ministry of Health, Mexico City 11000, Mexico)

  • Sonia Nava-Salazar

    (Immunobiochemistry Department, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico)

  • Sandra Rodríguez-Martínez

    (Innate Immunology Laboratory, Immunology Department, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, Mexico City 11350, Mexico)

  • Sandra B. Parra-Hernández

    (Immunobiochemistry Department, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico)

  • Lourdes Schnaas

    (National Institute of Perinatology, Mexico City 11000, Mexico)

  • Blanca Vianey Suárez-Rico

    (Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico)

  • Libni A. Torres-Olascoaga

    (National Institute of Public Health, Cuernavaca 62100, Mexico)

  • Andrea A. Baccarelli

    (Department of Environmental Health Sciences, Columbia University, New York, NY 10029, USA)

  • Rosalind J. Wright

    (Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Robert O. Wright

    (Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Department of Environmental Medicine and Public Health, Icahn School of Medicine, New York, NY 10029, USA)

  • Guadalupe Estrada-Gutierrez

    (Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico)

  • Marcela Tamayo-Ortiz

    (Research Unit in Occupational Health, Mexican Social Security Institute, Mexico City 06720, Mexico)

Abstract

An altered mitochondrial DNA copy number (mtDNAcn) at birth can be a marker of increased disease susceptibility later in life. Gestational exposure to acute stress, such as that derived from the earthquake experienced on 19 September 2017 in Mexico City, could be associated with changes in mtDNAcn at birth. Our study used data from the OBESO (Biochemical and Epigenetic Origins of Overweight and Obesity) perinatal cohort in Mexico City. We compared the mtDNAcn in the umbilical cord blood of 22 infants born before the earthquake, 24 infants whose mothers were pregnant at the time of the earthquake (exposed), and 37 who were conceived after the earthquake (post-earthquake). We quantified mtDNAcn by quantitative real-time polymerase chain reaction normalized with a nuclear gene. We used a linear model adjusted by maternal age, body mass index, socioeconomic status, perceived stress, and pregnancy comorbidities. Compared to non-exposed newborns (mean ± SD mtDNAcn: 0.740 ± 0.161), exposed and post-earthquake newborns (mtDNAcn: 0.899 ± 0.156 and 0.995 ± 0.169, respectively) had increased mtDNAcn, p = 0.001. The findings of this study point at mtDNAcn as a potential biological marker of acute stress and suggest that experiencing an earthquake during pregnancy or before gestation can have programing effects in the unborn child. Long-term follow-up of newborns to women who experience stress prenatally, particularly that derived from a natural disaster, is warranted.

Suggested Citation

  • Jonatan A. Mendoza-Ortega & Enrique Reyes-Muñoz & Sonia Nava-Salazar & Sandra Rodríguez-Martínez & Sandra B. Parra-Hernández & Lourdes Schnaas & Blanca Vianey Suárez-Rico & Libni A. Torres-Olascoaga &, 2021. "Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage," IJERPH, MDPI, vol. 18(22), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:11771-:d:675618
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    References listed on IDEAS

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    1. Kim, Bongkyun & Carruthers, Celeste K. & Harris, Matthew C., 2017. "Maternal stress and birth outcomes: Evidence from the 1994 Northridge earthquake," Journal of Economic Behavior & Organization, Elsevier, vol. 140(C), pages 354-373.
    2. Xiaoling Gu & Yanwen Yao & Guannan Wu & Tangfeng Lv & Liang Luo & Yong Song, 2013. "The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    3. Manja Wachsmuth & Alexander Hübner & Mingkun Li & Burkhard Madea & Mark Stoneking, 2016. "Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number," PLOS Genetics, Public Library of Science, vol. 12(3), pages 1-21, March.
    4. Seyram Kaali & Darby W. Jack & Rupert Delimini & Lisa Hu & Katrin Burkart & Jones Opoku-Mensah & Ashlinn Quinn & Kenneth Ayuurebobi Ae-Ngibise & Blair J. Wylie & Ellen Abrafi Boamah-Kaali & Steven Chi, 2018. "Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations," IJERPH, MDPI, vol. 16(1), pages 1-12, December.
    5. Constanza Morén & Sandra Hernández & Mariona Guitart-Mampel & Glòria Garrabou, 2014. "Mitochondrial Toxicity in Human Pregnancy: An Update on Clinical and Experimental Approaches in the Last 10 Years," IJERPH, MDPI, vol. 11(9), pages 1-22, September.
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    Keywords

    mtDNAcn; prenatal; DOHAD; earthquake;
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