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Associations between Household-Level Exposures and All-Cause Diarrhea and Pathogen-Specific Enteric Infections in Children Enrolled in Five Sentinel Surveillance Studies

Author

Listed:
  • Josh M. Colston

    (Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA 22903, USA)

  • Abu S. G. Faruque

    (Centre for Nutrition & Food Security, International Centre for Diarrhoeal Disease Research, Dhaka 1212, Bangladesh)

  • M. Jahangir Hossain

    (Medical Research Council Unit—The Gambia at the London School of Hygiene & Tropical Medicine, Banjul P.O. Box 273, Republic of Gambia)

  • Debasish Saha

    (Epidemiology and Health Economics, GSK Vaccines, 1300 Wavre, Belgium)

  • Suman Kanungo

    (Suman Kanungo—National Institute of Cholera and Enteric Diseases, Kolkota 700010, India)

  • Inácio Mandomando

    (Centro de Investigação em Saúde de Manhiça, Manhica CP 1929, Mozambique)

  • M. Imran Nisar

    (Department of Pediatrics and Child Health, The Aga Khan University, Karachi 74800, Pakistan)

  • Anita K. M. Zaidi

    (Department of Pediatrics and Child Health, The Aga Khan University, Karachi 74800, Pakistan)

  • Richard Omore

    (Kenya Medical Research Institute, Center for Global Health Research, Kisumu, Nyanza 40100, Kenya)

  • Robert F. Breiman

    (Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA)

  • Samba O. Sow

    (Centre pour le Développement des Vaccins, Bamako BP 251, Mali)

  • Anna Roose

    (Indiana University School of Medicine, Indianapolis, IN 46202, USA)

  • Myron M. Levine

    (Departments of Medicine and Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA)

  • Karen L. Kotloff

    (Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA)

  • Tahmeed Ahmed

    (Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh)

  • Pascal Bessong

    (HIV/AIDS & Global Health Research Programme, University of Venda, Thohoyandou, Limpopo 0950, South Africa)

  • Zulfiqar Bhutta

    (Department of Pediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan)

  • Estomih Mduma

    (Haydom Global Health Institute, Haydom P.O. Box 9000, Tanzania)

  • Pablo Penatero Yori

    (Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA 22903, USA)

  • Prakash Sunder Shrestha

    (Department of Child Health, Institute of Medicine of Tribhuvan University, Kirtipur 44618, Nepal)

  • Maribel P. Olortegui

    (Asociacion Benefica PRISMA, Iquitos 16006, Peru)

  • Gagandeep Kang

    (Department of Gastrointestinal Sciences, Christian Medical College, Vellore 632004, India)

  • Aldo A. M. Lima

    (Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza 60020-181, Brazil)

  • Jean Humphrey

    (Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MA 21205, USA)

  • Andrew Prendergast

    (Centre for Paediatrics, Blizard Institute, Queen Mary University of London, London E1 2AT, UK)

  • Francesca Schiaffino

    (Faculty of Veterinary Medicine, Universidad Peruana Cayetano Heredia, Lima 15102, Peru)

  • Benjamin F. Zaitchik

    (Department of Earth and Planetary Sciences, Johns Hopkins Krieger School of Arts and Sciences, Baltimore, MA 21218, USA)

  • Margaret N. Kosek

    (Division of Infectious Diseases, International Health and Public Health Sciences, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA)

Abstract

Diarrheal disease remains a major cause of childhood mortality and morbidity causing poor health and economic outcomes. In low-resource settings, young children are exposed to numerous risk factors for enteric pathogen transmission within their dwellings, though the relative importance of different transmission pathways varies by pathogen species. The objective of this analysis was to model associations between five household-level risk factors—water, sanitation, flooring, caregiver education, and crowding—and infection status for endemic enteric pathogens in children in five surveillance studies. Data were combined from 22 sites in which a total of 58,000 stool samples were tested for 16 specific enteropathogens using qPCR. Risk ratios for pathogen- and taxon-specific infection status were modeled using generalized linear models along with hazard ratios for all-cause diarrhea in proportional hazard models, with the five household-level variables as primary exposures adjusting for covariates. Improved drinking water sources conferred a 17% reduction in diarrhea risk; however, the direction of its association with particular pathogens was inconsistent. Improved sanitation was associated with a 9% reduction in diarrhea risk with protective effects across pathogen species and taxa of around 10–20% risk reduction. A 9% reduction in diarrhea risk was observed in subjects with covered floors, which were also associated with decreases in risk for zoonotic enteropathogens. Caregiver education and household crowding showed more modest, inconclusive results. Combining data from diverse sites, this analysis quantified associations between five household-level exposures on risk of specific enteric infections, effects which differed by pathogen species but were broadly consistent with hypothesized transmission mechanisms. Such estimates may be used within expanded water, sanitation, and hygiene (WASH) programs to target interventions to the particular pathogen profiles of individual communities and prioritize resources.

Suggested Citation

  • Josh M. Colston & Abu S. G. Faruque & M. Jahangir Hossain & Debasish Saha & Suman Kanungo & Inácio Mandomando & M. Imran Nisar & Anita K. M. Zaidi & Richard Omore & Robert F. Breiman & Samba O. Sow & , 2020. "Associations between Household-Level Exposures and All-Cause Diarrhea and Pathogen-Specific Enteric Infections in Children Enrolled in Five Sentinel Surveillance Studies," IJERPH, MDPI, vol. 17(21), pages 1-18, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8078-:d:439034
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    References listed on IDEAS

    as
    1. Mark E. McGovern & Aditi Krishna & Victor M. Aguayo & S.V. Subramanian, 2017. "A Review of the Evidence Linking Child Stunting to Economic Outcomes," CHaRMS Working Papers 17-03, Centre for HeAlth Research at the Management School (CHaRMS).
    2. Marquis, G.S. & Ventura, G. & Gilman, R.H. & Porras, E. & Miranda, E. & Carbajal, L. & Pentafiel, M., 1990. "Fecal contamination of shanty town toddlers in households with non-corralled poultry, Lima, Peru," American Journal of Public Health, American Public Health Association, vol. 80(2), pages 146-149.
    3. Basu, Alaka Malwade & Stephenson, Rob, 2005. "Low levels of maternal education and the proximate determinants of childhood mortality: a little learning is not a dangerous thing," Social Science & Medicine, Elsevier, vol. 60(9), pages 2011-2023, May.
    4. Harriet Whiley & Ben Van den Akker & Steven Giglio & Richard Bentham, 2013. "The Role of Environmental Reservoirs in Human Campylobacteriosis," IJERPH, MDPI, vol. 10(11), pages 1-22, November.
    5. Nicholas Graetz & Joseph Friedman & Aaron Osgood-Zimmerman & Roy Burstein & Molly H. Biehl & Chloe Shields & Jonathan F. Mosser & Daniel C. Casey & Aniruddha Deshpande & Lucas Earl & Robert C. Reiner , 2018. "Mapping local variation in educational attainment across Africa," Nature, Nature, vol. 555(7694), pages 48-53, March.
    6. Josh Colston & Maribel Paredes Olortegui & Benjamin Zaitchik & Pablo Peñataro Yori & Gagandeep Kang & Tahmeed Ahmed & Pascal Bessong & Esto Mduma & Zulfiqar Bhutta & Prakash Sunder Shrestha & Aldo Lim, 2020. "Pathogen-Specific Impacts of the 2011–2012 La Niña-Associated Floods on Enteric Infections in the MAL-ED Peru Cohort: A Comparative Interrupted Time Series Analysis," IJERPH, MDPI, vol. 17(2), pages 1-17, January.
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