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The Prevalence of Dry Eye Syndrome’s and the Likelihood to Develop Sjögren’s Syndrome in Taiwan: A Population-Based Study

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  • Ju-Chuan Yen

    (Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan
    Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch, Taipei 115, Taiwan)

  • Chia-An Hsu

    (School of Medicine, National Yang-Ming University, Taipei 112, Taiwan)

  • Yu-Chuan (Jack) Li

    (Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan
    These authors contributed equally to this work.)

  • Min-Huei Hsu

    (Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan
    Ministry of Health and Welfare, Taipei 115, Taiwan
    These authors contributed equally to this work.)

Abstract

Background : Dry eye syndrome (DES) is one of the key clinical features and possibly an early clinical presentation of Sjögren’s syndrome (SS). We explore DES prevalence and assess the likelihood of DES patients to develop SS in Taiwan through the National Health Insurance Research Database (NHIRD). Methods : Through a cohort comparison study, longitudinal data from the NHIRD (2000 to 2008) in Taiwan was used to probe the prevalence of DES and the odds that DES patients would later develop SS. Results : The prevalence of DES in the present study is 4.87%. The incidence rates of developing SS were 4.8% for the DES group and 1.5% for comparison group. The median age and interquartile range of DES and comparison patients was 49.8 (10) and 48.7 (15) years old, respectively. The crude hazard ratio (with 95% confidence interval) for DES patients to develop SS was 3.13 (3.10–3.50) for the DES group, and the adjusted hazard ratio (with 95% confidence interval) was 3.64 (3.43–3.87). The observation period and interquartile range for DES and comparison patients to develop SS later were 1418 (781–2316) versus 1641 (971–2512) days respectively. Conclusions : DES patients carried a higher risk for developing SS (hazard ratio 3.13) and presented for SS 3.88 years earlier than comparison group patients in this study.

Suggested Citation

  • Ju-Chuan Yen & Chia-An Hsu & Yu-Chuan (Jack) Li & Min-Huei Hsu, 2015. "The Prevalence of Dry Eye Syndrome’s and the Likelihood to Develop Sjögren’s Syndrome in Taiwan: A Population-Based Study," IJERPH, MDPI, vol. 12(7), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:7647-7655:d:52236
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    1. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
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    Cited by:

    1. Ju-Chuan Yen & Chia-An Hsu & Sheng-Huang Hsiao & Min-Huei Hsu, 2017. "Acute Anterior Uveitis as a Risk Factor of Ankylosing Spondylitis—A National Population-Based Study," IJERPH, MDPI, vol. 14(1), pages 1-7, January.
    2. Chia-Yi Lee & Kun-Lin Yang & Chi-Chin Sun & Jing-Yang Huang & Hung-Chih Chen & Hung-Chi Chen & Shun-Fa Yang, 2020. "The Development of Dry Eye Disease after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(11), pages 1-10, May.
    3. Kuan-Han Lin & Chien-Chia Su & Yen-Yuan Chen & Po-Ching Chu, 2019. "The Effects of Lighting Problems on Eye Symptoms among Cleanroom Microscope Workers," IJERPH, MDPI, vol. 16(1), pages 1-9, January.

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