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Vaccine supply chains in resource-limited settings: Mitigating the impact of rainy season disruptions

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  • De Boeck, Kim
  • Decouttere, Catherine
  • Jónasson, Jónas Oddur
  • Vandaele, Nico

Abstract

Immunization is widely recognized as one of the most successful and cost-effective health interventions, preventing two to three million deaths from vaccine-preventable diseases each year. Although progress has been made in recent years, substantial operational challenges persist in resource-limited settings with frequent stock-outs contributing to sub-optimal immunization coverage and inequality in vaccine access. In this paper, we investigate the role of rainy season induced supply chain disruptions on vaccination coverage and inequalities. We develop a modeling framework combining spatial modeling—to predict flood disruptions in road networks—and a discrete-event simulation of a multi-tiered vaccine supply chain (VSC). Our models are fitted using data from the Malagasy VSC network and validated to the best extent possible with scarce data. Our baseline simulation predicts the national vaccination coverage with good accuracy and suggests that 67% of regions with low reported immunization coverage are affected by rainy season disruptions or operational inefficiencies, causing significant geographical inequalities in vaccine access. We investigate various mitigation strategies to increase the resiliency of VSCs and find that, by strategically placing buffer inventory at targeted facilities prior to the rainy season, the proportion of children receiving all basic vaccines in these areas is increased by 8% and the geographical inequality in vaccination coverage between areas affected and not affected by the rainy season is reduced by 11%. By also increasing the replenishment frequency from every third month to every month, the national vaccination coverage improves by 41%. Our results contribute to achieving the UN Sustainable Development Goals (SDGs) by providing actionable insights for improving vaccination coverage (SDG 3) and investigating the resiliency of the VSC to increased flooding due to climate change (SDG 13).

Suggested Citation

  • De Boeck, Kim & Decouttere, Catherine & Jónasson, Jónas Oddur & Vandaele, Nico, 2022. "Vaccine supply chains in resource-limited settings: Mitigating the impact of rainy season disruptions," European Journal of Operational Research, Elsevier, vol. 301(1), pages 300-317.
    • Handle: RePEc:eee:ejores:v:301:y:2022:i:1:p:300-317
    DOI: 10.1016/j.ejor.2021.10.040
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    References listed on IDEAS

    as
    1. Emel Aktaş & Özay Özaydın & Burçin Bozkaya & Füsun Ülengin & Şule Önsel, 2013. "Optimizing Fire Station Locations for the Istanbul Metropolitan Municipality," Interfaces, INFORMS, vol. 43(3), pages 240-255, May-June.
    2. S Pamuk & M Köksalan & R Güllü, 2004. "Analysis and improvement of the product delivery system of a beer producer in Ankara," Journal of the Operational Research Society, Palgrave Macmillan;The OR Society, vol. 55(11), pages 1137-1144, November.
    3. Marilène Cherkesly & Marie‐Ève Rancourt & Karen R. Smilowitz, 2019. "Community Healthcare Network in Underserved Areas: Design, Mathematical Models, and Analysis," Production and Operations Management, Production and Operations Management Society, vol. 28(7), pages 1716-1734, July.
    4. Don Weigel & Buyang Cao, 1999. "Applying GIS and OR Techniques to Solve Sears Technician-Dispatching and Home Delivery Problems," Interfaces, INFORMS, vol. 29(1), pages 112-130, February.
    5. Bram Kin & Tomas Ambra & Sara Verlinde & Cathy Macharis, 2018. "Tackling Fragmented Last Mile Deliveries to Nanostores by Utilizing Spare Transportation Capacity—A Simulation Study," Sustainability, MDPI, vol. 10(3), pages 1-15, February.
    6. De Boeck, Kim & Decouttere, Catherine & Vandaele, Nico, 2020. "Vaccine distribution chains in low- and middle-income countries: A literature review," Omega, Elsevier, vol. 97(C).
    7. Gu, Liyi & Ryzhov, Ilya O. & Eftekhar, Mahyar, 2021. "The facts on the ground: Evaluating humanitarian fleet management policies using simulation," European Journal of Operational Research, Elsevier, vol. 293(2), pages 681-702.
    8. Raghu KC & Mika Aalto & Olli-Jussi Korpinen & Tapio Ranta & Svetlana Proskurina, 2020. "Lifecycle Assessment of Biomass Supply Chain with the Assistance of Agent-Based Modelling," Sustainability, MDPI, vol. 12(5), pages 1-14, March.
    9. Ngai-Hang Z Leung & Ana Chen & Prashant Yadav & Jérémie Gallien, 2016. "The Impact of Inventory Management on Stock-Outs of Essential Drugs in Sub-Saharan Africa: Secondary Analysis of a Field Experiment in Zambia," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-18, May.
    10. D. J. Weiss & A. Nelson & H. S. Gibson & W. Temperley & S. Peedell & A. Lieber & M. Hancher & E. Poyart & S. Belchior & N. Fullman & B. Mappin & U. Dalrymple & J. Rozier & T. C. D. Lucas & R. E. Howes, 2018. "A global map of travel time to cities to assess inequalities in accessibility in 2015," Nature, Nature, vol. 553(7688), pages 333-336, January.
    11. Rodríguez-Espíndola, Oscar & Albores, Pavel & Brewster, Christopher, 2018. "Dynamic formulation for humanitarian response operations incorporating multiple organisations," International Journal of Production Economics, Elsevier, vol. 204(C), pages 83-98.
    12. Doerner, Karl & Focke, Axel & Gutjahr, Walter J., 2007. "Multicriteria tour planning for mobile healthcare facilities in a developing country," European Journal of Operational Research, Elsevier, vol. 179(3), pages 1078-1096, June.
    13. Maria Besiou & Alfonso J. Pedraza-Martinez & Luk N. Van Wassenhove, 2014. "Vehicle Supply Chains in Humanitarian Operations: Decentralization, Operational Mix, and Earmarked Funding," Production and Operations Management, Production and Operations Management Society, vol. 23(11), pages 1950-1965, November.
    14. Harper, P. R. & Shahani, A. K. & Gallagher, J. E. & Bowie, C., 2005. "Planning health services with explicit geographical considerations: a stochastic location-allocation approach," Omega, Elsevier, vol. 33(2), pages 141-152, April.
    15. Milad Keshvari Fard & Mahyar Eftekhar & Felix Papier, 2019. "An Approach for Managing Operating Assets for Humanitarian Development Programs," Production and Operations Management, Production and Operations Management Society, vol. 28(8), pages 2132-2151, August.
    16. Smith, Honora K. & Harper, Paul R. & Potts, Chris N. & Thyle, Ann, 2009. "Planning sustainable community health schemes in rural areas of developing countries," European Journal of Operational Research, Elsevier, vol. 193(3), pages 768-777, March.
    17. Carland, Corinne & Goentzel, Jarrod & Montibeller, Gilberto, 2018. "Modeling the values of private sector agents in multi-echelon humanitarian supply chains," European Journal of Operational Research, Elsevier, vol. 269(2), pages 532-543.
    18. Alfonso J. Pedraza-Martinez & Sameer Hasija & Luk N. Van Wassenhove, 2020. "Fleet Coordination in Decentralized Humanitarian Operations Funded by Earmarked Donations," Operations Research, INFORMS, vol. 68(4), pages 984-999, July.
    19. Harwin de Vries & Joris van de Klundert & Albert P.M. Wagelmans, 2020. "The Roadside Healthcare Facility Location Problem A Managerial Network Design Challenge," Production and Operations Management, Production and Operations Management Society, vol. 29(5), pages 1165-1187, May.
    20. Rafael Epstein & Andrés Weintraub & Pedro Sapunar & Enrique Nieto & Julian B. Sessions & John Sessions & Fernando Bustamante & Hugo Musante, 2006. "A Combinatorial Heuristic Approach for Solving Real-Size Machinery Location and Road Design Problems in Forestry Planning," Operations Research, INFORMS, vol. 54(6), pages 1017-1027, December.
    21. Gemma Berenguer & Pinar Keskinocak & J. George Shanthikumar & Jayashankar M. Swaminathan & Luk Van Wassenhove & Karthik V. Natarajan & Jayashankar M. Swaminathan, 2017. "Multi-Treatment Inventory Allocation in Humanitarian Health Settings under Funding Constraints," Production and Operations Management, Production and Operations Management Society, vol. 26(6), pages 1015-1034, June.
    22. Rodríguez-Espíndola, Oscar & Albores, Pavel & Brewster, Christopher, 2018. "Disaster preparedness in humanitarian logistics: A collaborative approach for resource management in floods," European Journal of Operational Research, Elsevier, vol. 264(3), pages 978-993.
    23. Karthik V. Natarajan & Jayashankar M. Swaminathan, 2014. "Inventory Management in Humanitarian Operations: Impact of Amount, Schedule, and Uncertainty in Funding," Manufacturing & Service Operations Management, INFORMS, vol. 16(4), pages 595-603, October.
    24. Hongtao Ren & Wenji Zhou & Ying Guo & Lizhen Huang & Yongping Liu & Yadong Yu & Liyun Hong & Tieju Ma, 2020. "A GIS-based green supply chain model for assessing the effects of carbon price uncertainty on plastic recycling," International Journal of Production Research, Taylor & Francis Journals, vol. 58(6), pages 1705-1723, March.
    25. Tarantilis, C. D. & Diakoulaki, D. & Kiranoudis, C. T., 2004. "Combination of geographical information system and efficient routing algorithms for real life distribution operations," European Journal of Operational Research, Elsevier, vol. 152(2), pages 437-453, January.
    26. Özdamar, Linet & Ertem, Mustafa Alp, 2015. "Models, solutions and enabling technologies in humanitarian logistics," European Journal of Operational Research, Elsevier, vol. 244(1), pages 55-65.
    27. Gemma Berenguer & Pinar Keskinocak & J. George Shanthikumar & Jayashankar M. Swaminathan & Luk Van Wassenhove & Jérémie Gallien & Iva Rashkova & Rifat Atun & Prashant Yadav, 2017. "National Drug Stockout Risks and the Global Fund Disbursement Process for Procurement," Production and Operations Management, Production and Operations Management Society, vol. 26(6), pages 997-1014, June.
    28. Jeffrey D. Camm & Thomas E. Chorman & Franz A. Dill & James R. Evans & Dennis J. Sweeney & Glenn W. Wegryn, 1997. "Blending OR/MS, Judgment, and GIS: Restructuring P&G's Supply Chain," Interfaces, INFORMS, vol. 27(1), pages 128-142, February.
    29. Chen, Yuh-Wen & Wang, Chi-Hwang & Lin, Sain-Ju, 2008. "A multi-objective geographic information system for route selection of nuclear waste transport," Omega, Elsevier, vol. 36(3), pages 363-372, June.
    30. Sarang Deo & Milind Sohoni, 2015. "Optimal Decentralization of Early Infant Diagnosis of HIV in Resource-Limited Settings," Manufacturing & Service Operations Management, INFORMS, vol. 17(2), pages 191-207, May.
    31. Jessica H. McCoy & Hau L. Lee, 2014. "Using Fairness Models to Improve Equity in Health Delivery Fleet Management," Production and Operations Management, Production and Operations Management Society, vol. 23(6), pages 965-977, June.
    32. Lasry, Arielle & Zaric, Gregory S. & Carter, Michael W., 2007. "Multi-level resource allocation for HIV prevention: A model for developing countries," European Journal of Operational Research, Elsevier, vol. 180(2), pages 786-799, July.
    33. Jónas Oddur Jónasson & Sarang Deo & Jérémie Gallien, 2017. "Improving HIV Early Infant Diagnosis Supply Chains in Sub-Saharan Africa: Models and Application to Mozambique," Operations Research, INFORMS, vol. 65(6), pages 1479-1493, December.
    34. Mahyar Eftekhar & Andrea Masini & A. Robotis & Luk van Wassenhove, 2014. "Vehicle Procurement Policy for Humanitarian Development Programs," Post-Print hal-01066490, HAL.
    35. Terry A. Taylor & Wenqiang Xiao, 2014. "Subsidizing the Distribution Channel: Donor Funding to Improve the Availability of Malaria Drugs," Management Science, INFORMS, vol. 60(10), pages 2461-2477, October.
    36. Murray, Alan T., 2021. "Contemporary optimization application through geographic information systems," Omega, Elsevier, vol. 99(C).
    37. Mahyar Eftekhar & Andrea Masini & Andreas Robotis & Luk N. Van Wassenhove, 2014. "Vehicle Procurement Policy for Humanitarian Development Programs," Production and Operations Management, Production and Operations Management Society, vol. 23(6), pages 951-964, June.
    38. Dursun Delen & Madhav Erraguntla & Richard Mayer & Chang-Nien Wu, 2011. "Better management of blood supply-chain with GIS-based analytics," Annals of Operations Research, Springer, vol. 185(1), pages 181-193, May.
    39. P R Harper & S Phillips & J E Gallagher, 2005. "Geographical simulation modelling for the regional planning of oral and maxillofacial surgery across London," Journal of the Operational Research Society, Palgrave Macmillan;The OR Society, vol. 56(2), pages 134-143, February.
    40. Núñez Ares, José & de Vries, Harwin & Huisman, Dennis, 2016. "A column generation approach for locating roadside clinics in Africa based on effectiveness and equity," European Journal of Operational Research, Elsevier, vol. 254(3), pages 1002-1016.
    41. Zhang, Fengli & Johnson, Dana & Johnson, Mark & Watkins, David & Froese, Robert & Wang, Jinjiang, 2016. "Decision support system integrating GIS with simulation and optimisation for a biofuel supply chain," Renewable Energy, Elsevier, vol. 85(C), pages 740-748.
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