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Uncertainty quantification of a mathematical model of COVID-19 transmission dynamics with mass vaccination strategy

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  • Olivares, Alberto
  • Staffetti, Ernesto

Abstract

In this paper, the uncertainty quantification and sensitivity analysis of a mathematical model of the SARS-CoV-2 virus transmission dynamics with mass vaccination strategy has been carried out. More specifically, a compartmental epidemic model has been considered, in which vaccination, social distance measures, and testing of susceptible individuals have been included. Since the application of these mitigation measures entails a degree of uncertainty, the effects of the uncertainty about the application of social distance actions and testing of susceptible individuals on the disease transmission have been quantified, under the assumption of a mass vaccination program deployment. A spectral approach has been employed, which allows the uncertainty propagation through the epidemic model to be represented by means of the polynomial chaos expansion of the output random variables. In particular, a statistical moment-based polynomial chaos expansion has been implemented, which provides a surrogate model for the compartments of the epidemic model, and allows the statistics, the probability distributions of the interesting output variables of the model at a given time instant to be estimated and the sensitivity analysis to be conducted. The purpose of the sensitivity analysis is to understand which uncertain parameters have most influence on a given output random variable of the model at a given time instant. Several numerical experiments have been conducted whose results show that the proposed spectral approach to uncertainty quantification and sensitivity analysis of epidemic models provides a useful tool to control and mitigate the effects of the COVID-19 pandemic, when it comes to healthcare resource planning.

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  • Olivares, Alberto & Staffetti, Ernesto, 2021. "Uncertainty quantification of a mathematical model of COVID-19 transmission dynamics with mass vaccination strategy," Chaos, Solitons & Fractals, Elsevier, vol. 146(C).
    • Handle: RePEc:eee:chsofr:v:146:y:2021:i:c:s0960077921002484
    DOI: 10.1016/j.chaos.2021.110895
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    References listed on IDEAS

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    1. Cooper, Ian & Mondal, Argha & Antonopoulos, Chris G., 2020. "A SIR model assumption for the spread of COVID-19 in different communities," Chaos, Solitons & Fractals, Elsevier, vol. 139(C).
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    4. Ndaïrou, Faïçal & Area, Iván & Nieto, Juan J. & Torres, Delfim F.M., 2020. "Mathematical modeling of COVID-19 transmission dynamics with a case study of Wuhan," Chaos, Solitons & Fractals, Elsevier, vol. 135(C).
    5. Oladyshkin, S. & Nowak, W., 2012. "Data-driven uncertainty quantification using the arbitrary polynomial chaos expansion," Reliability Engineering and System Safety, Elsevier, vol. 106(C), pages 179-190.
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    Cited by:

    1. Vahideh Vakil & Wade Trappe, 2022. "Projecting the Pandemic Trajectory through Modeling the Transmission Dynamics of COVID-19," IJERPH, MDPI, vol. 19(8), pages 1-28, April.
    2. Bimal Kumar Mishra, 2022. "Stochastic models on the transmission of novel COVID-19," International Journal of System Assurance Engineering and Management, Springer;The Society for Reliability, Engineering Quality and Operations Management (SREQOM),India, and Division of Operation and Maintenance, Lulea University of Technology, Sweden, vol. 13(2), pages 599-603, April.
    3. Huda Abdul Satar & Raid Kamel Naji, 2023. "A Mathematical Study for the Transmission of Coronavirus Disease," Mathematics, MDPI, vol. 11(10), pages 1-20, May.
    4. Svetozar Margenov & Nedyu Popivanov & Iva Ugrinova & Tsvetan Hristov, 2022. "Mathematical Modeling and Short-Term Forecasting of the COVID-19 Epidemic in Bulgaria: SEIRS Model with Vaccination," Mathematics, MDPI, vol. 10(15), pages 1-28, July.
    5. de Mello-Sampayo, F.;, 2024. "Uncertainty in Healthcare Policy Decisions: An Epidemiological Real Options Approach to COVID-19 Lockdown Exits," Health, Econometrics and Data Group (HEDG) Working Papers 24/01, HEDG, c/o Department of Economics, University of York.
    6. Olivares, Alberto & Staffetti, Ernesto, 2023. "A statistical moment-based spectral approach to the chance-constrained stochastic optimal control of epidemic models," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).
    7. Javier Cifuentes-Faura & Ursula Faura-Martínez & Matilde Lafuente-Lechuga, 2022. "Mathematical Modeling and the Use of Network Models as Epidemiological Tools," Mathematics, MDPI, vol. 10(18), pages 1-14, September.

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