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MAPK and AKT Pathway Intersection in Neuroblastoma Cells

Author

Listed:
  • Aysegul Yildiz

    (Department of Molecular Biology and Genetics, Muğla Sıtkı Koçman University, Turkey)

  • Ozgur Tanriverdi

    (Molecular Biology and Genetics, Muğla Sıtkı Koçman University, Turkey
    Department of Medical Oncology, Muğla Sıtkı Koçman University, Turkey)

Abstract

One of the most important contributing factors for cancer development is the aberrant activation of mitogenic MAPK and AKT survival pathways. Abnormal activities of these pathways also indicates poor prognosis as a result of drug resistance in cancer treatment. It is revealed that there is a cross-talk between these two signaling cascades and they act together by one triggering the other performing an anti-apoptotic effect. It is evident that interplay between MAPK and AKT pathways is at the center of poor prognosis especially in neuroblastoma. However, it is still unknown what is there at the heart of this interaction. In this mini review, tumorigenic and chemotherapy-resistant effects of MAPK and AKT pathways and also the effect of their cross-talk in neuroblastoma and other cancers is summarized.

Suggested Citation

  • Aysegul Yildiz & Ozgur Tanriverdi, 2017. "MAPK and AKT Pathway Intersection in Neuroblastoma Cells," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 2(1), pages 17-20, March.
    • Handle: RePEc:adp:jctbeb:v:2:y:2017:i:1:p:17-20
    DOI: 10.19080/CTBEB.2017.02.555580
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    References listed on IDEAS

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    1. Lufen Chang & Michael Karin, 2001. "Mammalian MAP kinase signalling cascades," Nature, Nature, vol. 410(6824), pages 37-40, March.
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