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Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

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  • Chih-Chien Wang
  • Chih-Yun Huang
  • Meng-Chang Lee
  • Dung-Jang Tsai
  • Chia-Chun Wu
  • Sui-Lung Su

Abstract

Background: Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained. Objective: This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA. Methods: Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren–Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue. Results: A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62–1.15) in the recessive model] in the present case–control study, and analysis of other genetic models showed a similar trend. After adding the critical case–control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56–4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion. Conclusions: The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required.

Suggested Citation

  • Chih-Chien Wang & Chih-Yun Huang & Meng-Chang Lee & Dung-Jang Tsai & Chia-Chun Wu & Sui-Lung Su, 2021. "Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-15, November.
    • Handle: RePEc:plo:pone00:0259561
    DOI: 10.1371/journal.pone.0259561
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