IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0145505.html
   My bibliography  Save this article

Protein Diet Restriction Slows Chronic Kidney Disease Progression in Non-Diabetic and in Type 1 Diabetic Patients, but Not in Type 2 Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials Using Glomerular Filtration Rate as a Surrogate

Author

Listed:
  • Mahesh Shumsher Rughooputh
  • Rui Zeng
  • Ying Yao

Abstract

Background/ Objective: Studies, including various meta-analyses, on the effect of Protein Diet Restriction on Glomerular Filtration Rate (GFR) in Chronic Kidney Disease (CKD) have reported conflicting results. In this paper, we have provided an update on the evidence available on this topic. We have investigated the reasons why the effect has been inconsistent across studies. We have also compared the effect on GFR in various subgroups including type 1 diabetics, type 2 diabetics and non-diabetics. Method: We searched for Randomized Controlled Trials on this intervention from MEDLINE, EMBASE, and other information sources. The PRISMA guidelines, as well as recommended meta-analysis practices were followed in the selection process, analysis and reporting of our findings. The effect estimate used was the change in mean GFR. Heterogeneity across the considered studies was explored using both subgroup analyses and meta-regression. Quality assessment was done using the Cochrane risk of bias tool and sensitivity analyses. Results: 15 randomized controlled trials, including 1965 subjects, were analyzed. The pooled effect size, as assessed using random-effects model, for all the 15 studies was -0.95 ml/min/1.73m2/year (95% CI: -1.79, -0.11), with a significant p value of 0.03. The combined effect estimate for the non-diabetic and type 1 diabetic studies was -1.50 ml/min/1.73m2/year (95% CI: -2.73, -0.26) with p value of 0.02. The effect estimate for the type 2 diabetic group was -0.17 ml/min/1.73m2/year (95% CI: -1.88, 1.55) with p value of 0.85. There was significant heterogeneity across the included studies (I2 = 74%, p value for Q

Suggested Citation

  • Mahesh Shumsher Rughooputh & Rui Zeng & Ying Yao, 2015. "Protein Diet Restriction Slows Chronic Kidney Disease Progression in Non-Diabetic and in Type 1 Diabetic Patients, but Not in Type 2 Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials ," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-17, December.
    • Handle: RePEc:plo:pone00:0145505
    DOI: 10.1371/journal.pone.0145505
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145505
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145505&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0145505?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Lukas Schwingshackl & Georg Hoffmann, 2014. "Comparison of High vs. Normal/Low Protein Diets on Renal Function in Subjects without Chronic Kidney Disease: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-13, May.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    3. Kenneth F Schulz & Douglas G Altman & David Moher & for the CONSORT Group, 2010. "CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-7, March.
    4. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Su Keng Tan & Wai Keung Leung & Alexander Tin Hong Tang & Roger A Zwahlen, 2017. "Effects of mandibular setback with or without maxillary advancement osteotomies on pharyngeal airways: An overview of systematic reviews," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-20, October.
    2. Jovana Kuzmanovic Pficer & Slobodan Dodic & Vojkan Lazic & Goran Trajkovic & Natasa Milic & Biljana Milicic, 2017. "Occlusal stabilization splint for patients with temporomandibular disorders: Meta-analysis of short and long term effects," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-21, February.
    3. Piers Steel & Sjoerd Beugelsdijk & Herman Aguinis, 2021. "The anatomy of an award-winning meta-analysis: Recommendations for authors, reviewers, and readers of meta-analytic reviews," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 52(1), pages 23-44, February.
    4. Clovis Mariano Faggion Jr & Yun-Chun Wu & Moritz Scheidgen & Yu-Kang Tu, 2015. "Effect of Risk of Bias on the Effect Size of Meta-Analytic Estimates in Randomized Controlled Trials in Periodontology and Implant Dentistry," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-9, September.
    5. Salvador Angosto & Jerónimo García-Fernández & Irena Valantine & Moisés Grimaldi-Puyana, 2020. "The Intention to Use Fitness and Physical Activity Apps: A Systematic Review," Sustainability, MDPI, vol. 12(16), pages 1-25, August.
    6. Libing Jiang & Shouyin Jiang & Mao Zhang & Zhongjun Zheng & Yuefeng Ma, 2014. "Albumin versus Other Fluids for Fluid Resuscitation in Patients with Sepsis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-21, December.
    7. Christopher Winchester & Kelsey E. Medeiros, 2023. "In Bounds but Out of the Box: A Meta-Analysis Clarifying the Effect of Ethicality on Creativity," Journal of Business Ethics, Springer, vol. 183(3), pages 713-743, March.
    8. Kelly R Moran & Sara Y Del Valle, 2016. "A Meta-Analysis of the Association between Gender and Protective Behaviors in Response to Respiratory Epidemics and Pandemics," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-25, October.
    9. Laith Hussain-Alkhateeb & Tatiana Rivera Ramírez & Axel Kroeger & Ernesto Gozzer & Silvia Runge-Ranzinger, 2021. "Early warning systems (EWSs) for chikungunya, dengue, malaria, yellow fever, and Zika outbreaks: What is the evidence? A scoping review," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 15(9), pages 1-25, September.
    10. Sandra Feijóo & Raquel Rodríguez-Fernández, 2021. "A Meta-Analytical Review of Gender-Based School Bullying in Spain," IJERPH, MDPI, vol. 18(23), pages 1-13, December.
    11. Xizheng Xu & Zhiqiang Liu & Shaoying Gong & Yunpeng Wu, 2022. "The Relationship between Empathy and Attachment in Children and Adolescents: Three-Level Meta-Analyses," IJERPH, MDPI, vol. 19(3), pages 1-18, January.
    12. Kathrin Wunsch & Janis Fiedler & Philip Bachert & Alexander Woll, 2021. "The Tridirectional Relationship among Physical Activity, Stress, and Academic Performance in University Students: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(2), pages 1-18, January.
    13. Alan da Silveira Fleck & Margaux L. Sadoine & Stéphane Buteau & Eva Suarthana & Maximilien Debia & Audrey Smargiassi, 2021. "Environmental and Occupational Short-Term Exposure to Airborne Particles and FEV 1 and FVC in Healthy Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(20), pages 1-19, October.
    14. Evangelos Danopoulos & Maureen Twiddy & Jeanette M Rotchell, 2020. "Microplastic contamination of drinking water: A systematic review," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-23, July.
    15. Claudia Menne-Lothmann & Wolfgang Viechtbauer & Petra Höhn & Zuzana Kasanova & Simone P Haller & Marjan Drukker & Jim van Os & Marieke Wichers & Jennifer Y F Lau, 2014. "How to Boost Positive Interpretations? A Meta-Analysis of the Effectiveness of Cognitive Bias Modification for Interpretation," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-26, June.
    16. Shalin Lee Wan Fei & Khatijah L Abdullah, 2015. "Effect of turning vs. supine position under phototherapy on neonates with hyperbilirubinemia: a systematic review," Journal of Clinical Nursing, John Wiley & Sons, vol. 24(5-6), pages 672-682, March.
    17. Savita Bakhshi & Alison E. While, 2013. "Health Professionals’ Alcohol-Related Professional Practices and the Relationship between Their Personal Alcohol Attitudes and Behavior and Professional Practices: A Systematic Review," IJERPH, MDPI, vol. 11(1), pages 1-31, December.
    18. Finkelstein, Eric A. & Bilger, Marcel & Baid, Drishti, 2019. "Effectiveness and cost-effectiveness of incentives as a tool for prevention of non-communicable diseases: A systematic review," Social Science & Medicine, Elsevier, vol. 232(C), pages 340-350.
    19. João Carlos Belloti & Aldo Okamura & Jordana Scheeren & Flávio Faloppa & Vinícius Ynoe de Moraes, 2019. "A systematic review of the quality of distal radius systematic reviews: Methodology and reporting assessment," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-12, January.
    20. Kevin Rudolf & Lea A. L. Dejonghe & Ingo Froböse & Florian Lammer & Lisa-Marie Rückel & Jessica Tetz & Andrea Schaller, 2019. "Effectiveness Studies in Health Promotion: A Review of the Methodological Quality of Studies Reporting Significant Effects on Physical Activity in Working Age Adults," IJERPH, MDPI, vol. 16(5), pages 1-17, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0145505. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.