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Content
October 2017, Volume 550, Issue 7677
- 548-548 Addendum: Editorial Expression of Concern: Asia’s glaciers are a regionally important buffer against drought
by Hamish D. Pritchard - 548-548 Correction: Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
by Kai Liu & Juhyun Kim & Dong Won Kim & Yi Stephanie Zhang & Hechen Bao & Myrto Denaxa & Szu-Aun Lim & Eileen Kim & Chang Liu & Ian R. Wickersham & Vassilis Pachnis & Samer Hattar & Juan Song & Solange P. Brown & Seth Blackshaw - 548-548 Correction: Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours
by Aldo Scarpa & David K. Chang & Katia Nones & Vincenzo Corbo & Ann-Marie Patch & Peter Bailey & Rita T. Lawlor & Amber L. Johns & David K. Miller & Andrea Mafficini & Borislav Rusev & Maria Scardoni & Davide Antonello & Stefano Barbi & Katarzyna O. Sikora & Sara Cingarlini & Caterina Vicentini & Skye McKay & Michael C. J. Quinn & Timothy J. C. Bruxner & Angelika N. Christ & Ivon Harliwong & Senel Idrisoglu & Suzanne McLean & Craig Nourse & Ehsan Nourbakhsh & Peter J. Wilson & Matthew J. Anderson & J. Lynn Fink & Felicity Newell & Nick Waddell & Oliver Holmes & Stephen H. Kazakoff & Conrad Leonard & Scott Wood & Qinying Xu & Shivashankar Hiriyur Nagaraj & Eliana Amato & Irene Dalai & Samantha Bersani & Ivana Cataldo & Angelo P. Dei Tos & Paola Capelli & Maria Vittoria Davì & Luca Landoni & Anna Malpaga & Marco Miotto & Vicki L. J. Whitehall & Barbara A. Leggett & Janelle L. Harris & Jonathan Harris & Marc D. Jones & Jeremy Humphris & Lorraine A. Chantrill & Venessa Chin & Adnan M. Nagrial & Marina Pajic & Christopher J. Scarlett & Andreia Pinho & Ilse Rooman & Christopher Toon & Jianmin Wu & Mark Pinese & Mark Cowley & Andrew Barbour & Amanda Mawson & Emily S. Humphrey & Emily K. Colvin & Angela Chou & Jessica A. Lovell & Nigel B. Jamieson & Fraser Duthie & Marie-Claude Gingras & William E. Fisher & Rebecca A. Dagg & Loretta M. S. Lau & Michael Lee & Hilda A. Pickett & Roger R. Reddel & Jaswinder S. Samra & James G. Kench & Neil D. Merrett & Krishna Epari & Nam Q. Nguyen & Nikolajs Zeps & Massimo Falconi & Michele Simbolo & Giovanni Butturini & George Van Buren & Stefano Partelli & Matteo Fassan & Kum Kum Khanna & Anthony J. Gill & David A. Wheeler & Richard A. Gibbs & Elizabeth A. Musgrove & Claudio Bassi & Giampaolo Tortora & Paolo Pederzoli & John V. Pearson & Nicola Waddell & Andrew V. Biankin & Sean M. Grimmond - 549-552 Graduate survey: A love–hurt relationship
by Chris Woolston - 554-554 The Everywhere Bus
by Jonathan L. Howard
October 2017, Volume 550, Issue 7676
- 105-105 Amyotrophic lateral sclerosis
by Brian Owens - 106-108 The hexanucleotide hex
by Elie Dolgin - 109-111 Non-Familial ALS: A tangled web
by Carolyn Brown - 112-112 Perspective: Don't keep it in the family
by Ammar Al-Chalabi - 113-114 Fundraising: The Ice Bucket Challenge delivers
by Emily Sohn - 115-117 Calculating disease
by Neil Savage - 120-121 On the treatment trail for ALS
by Andrew Scott - 122-122 Perspective: Untangling the ALS X-Files
by Richard Bedlack - 157-157 Metropolis of minds
by Smriti Mallapaty - 164-166 Steeped in science
by Anna Petherick - 168-171 On the biotech block
by Alexandra Ossola - 172-172 Comment: Where the streets are paved with ideas
by Richard Florida - 176-179 Destination Daejeon
by Mark Zastrow - 180-183 Spain's science rivalry
by Monica G. Salomone - 186-187 A league of their own
by Hepeng Jia - 188-191 Neighbours in knowledge
by Hepeng Jia - 303-303 Give researchers a lifetime word limit
by Brian C. Martinson - 309-310 Colliding stars spark rush to solve cosmic mysteries
by Davide Castelvecchi - 310-311 Japanese research leaders warn about national science decline
by Nicky Phillips - 311-311 Trump EPA begins push to overturn Obama-era climate regulation
by Jeff Tollefson - 312-313 New definitions of scientific units are on the horizon
by Elizabeth Gibney - 314-314 FDA advisers back gene therapy for rare form of blindness
by Heidi Ledford - 316-319 The shape of work to come
by Emily Anthes - 321-324 Lessons from history for the future of work
by Robert C. Allen - 324-327 Reboot for the AI revolution
by Yuval Noah Harari - 327-329 The second Renaissance
by Ian Goldin - 330-331 Archaeology: The wonder of the pyramids
by Andrew Robinson - 331-331 Books in brief
by Barbara Kiser - 332-332 History: Five millennia of Indian science
by James Poskett - 333-333 Spot data glitches before publication
by Noah F. Greenwald & Pratiti Bandopadhayay & Rameen Beroukhim - 333-333 PhD students: side jobs are no solution
by Therice Morris - 333-333 PhD students: living wage key to diversity
by Larissa K. Barber & Nicholas A. Barber & Holly P. Jones - 333-333 Danish dairy farmer delivers data coup
by Tony Fox & Henning Heldbjerg - 333-333 Stifled by budgets, not irrelevance
by Thomas O. Baldwin - 336-337 Learning to play Go from scratch
by Satinder Singh & Andy Okun & Andrew Jackson - 337-339 Bacterial snack attack deactivates a drug
by Christian Jobin - 339-340 Data analysis meets quantum physics
by Steven Schramm - 340-341 Genome jail-break triggers lockdown
by Neil T. Umbreit & David Pellman - 342-343 Complex assistance for DNA invasion
by Petr Cejka - 343-344 Domains to the rescue for Rett syndrome
by Anne E. West - 345-353 DNA sequencing at 40: past, present and future
by Jay Shendure & Shankar Balasubramanian & George M. Church & Walter Gilbert & Jane Rogers & Jeffery A. Schloss & Robert H. Waterston - 354-359 Mastering the game of Go without human knowledge
by David Silver & Julian Schrittwieser & Karen Simonyan & Ioannis Antonoglou & Aja Huang & Arthur Guez & Thomas Hubert & Lucas Baker & Matthew Lai & Adrian Bolton & Yutian Chen & Timothy Lillicrap & Fan Hui & Laurent Sifre & George van den Driessche & Thore Graepel & Demis Hassabis - 360-365 BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
by Weixing Zhao & Justin B. Steinfeld & Fengshan Liang & Xiaoyong Chen & David G. Maranon & Chu Jian Ma & Youngho Kwon & Timsi Rao & Weibin Wang & Chen Sheng & Xuemei Song & Yanhong Deng & Judit Jimenez-Sainz & Lucy Lu & Ryan B. Jensen & Yong Xiong & Gary M. Kupfer & Claudia Wiese & Eric C. Greene & Patrick Sung - 366-370 Human TRPML1 channel structures in open and closed conformations
by Philip Schmiege & Michael Fine & Günter Blobel & Xiaochun Li - 371-374 A parts-per-billion measurement of the antiproton magnetic moment
by C. Smorra & S. Sellner & M. J. Borchert & J. A. Harrington & T. Higuchi & H. Nagahama & T. Tanaka & A. Mooser & G. Schneider & M. Bohman & K. Blaum & Y. Matsuda & C. Ospelkaus & W. Quint & J. Walz & Y. Yamazaki & S. Ulmer - 375-379 Solving a Higgs optimization problem with quantum annealing for machine learning
by Alex Mott & Joshua Job & Jean-Roch Vlimant & Daniel Lidar & Maria Spiropulu - 380-383 Ion sieving in graphene oxide membranes via cationic control of interlayer spacing
by Liang Chen & Guosheng Shi & Jie Shen & Bingquan Peng & Bowu Zhang & Yuzhu Wang & Fenggang Bian & Jiajun Wang & Deyuan Li & Zhe Qian & Gang Xu & Gongping Liu & Jianrong Zeng & Lijuan Zhang & Yizhou Yang & Guoquan Zhou & Minghong Wu & Wanqin Jin & Jingye Li & Haiping Fang - 384-387 Organic long persistent luminescence
by Ryota Kabe & Chihaya Adachi - 388-392 Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex
by Ryan Remedios & Ann Kennedy & Moriel Zelikowsky & Benjamin F. Grewe & Mark J. Schnitzer & David J. Anderson - 393-397 Establishment of mouse expanded potential stem cells
by Jian Yang & David J. Ryan & Wei Wang & Jason Cheuk-Ho Tsang & Guocheng Lan & Hideki Masaki & Xuefei Gao & Liliana Antunes & Yong Yu & Zhexin Zhu & Juexuan Wang & Aleksandra A. Kolodziejczyk & Lia S. Campos & Cui Wang & Fengtang Yang & Zhen Zhong & Beiyuan Fu & Melanie A. Eckersley-Maslin & Michael Woods & Yosuke Tanaka & Xi Chen & Adam C. Wilkinson & James Bussell & Jacqui White & Ramiro Ramirez-Solis & Wolf Reik & Berthold Göttgens & Sarah A. Teichmann & Patrick P. L. Tam & Hiromitsu Nakauchi & Xiangang Zou & Liming Lu & Pentao Liu - 398-401 Radically truncated MeCP2 rescues Rett syndrome-like neurological defects
by Rebekah Tillotson & Jim Selfridge & Martha V. Koerner & Kamal K. E. Gadalla & Jacky Guy & Dina De Sousa & Ralph D. Hector & Stuart R. Cobb & Adrian Bird - 402-406 Cytoplasmic chromatin triggers inflammation in senescence and cancer
by Zhixun Dou & Kanad Ghosh & Maria Grazia Vizioli & Jiajun Zhu & Payel Sen & Kirk J. Wangensteen & Johayra Simithy & Yemin Lan & Yanping Lin & Zhuo Zhou & Brian C. Capell & Caiyue Xu & Mingang Xu & Julia E. Kieckhaefer & Tianying Jiang & Michal Shoshkes-Carmel & K. M. Ahasan Al Tanim & Glen N. Barber & John T. Seykora & Sarah E. Millar & Klaus H. Kaestner & Benjamin A. Garcia & Peter D. Adams & Shelley L. Berger - 407-410 Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
by Janice S. Chen & Yavuz S. Dagdas & Benjamin P. Kleinstiver & Moira M. Welch & Alexander A. Sousa & Lucas B. Harrington & Samuel H. Sternberg & J. Keith Joung & Ahmet Yildiz & Jennifer A. Doudna - 411-414 Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
by Marscha Hirschi & Mark A. Herzik Jr & Jinhong Wie & Yang Suo & William F. Borschel & Dejian Ren & Gabriel C. Lander & Seok-Yong Lee - 415-418 Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
by Qingfeng Chen & Ji She & Weizhong Zeng & Jiangtao Guo & Haoxing Xu & Xiao-chen Bai & Youxing Jiang - 419-421 Flexible working: Science in the gig economy
by Roberta Kwok - 421-421 Trade talk: Habitat helper
by Sarah Boon - 424-424 Breaking and entering
by Hall Jameson
October 2017, Volume 550, Issue 7675
- 53-53 Climate change
by Richard Hodson - 54-58 Sea change
by Sarah DeWeerdt - 59-61 Getting political
by Peter Fairley - 62-64 The real climate debate
by Peter Agre & Mario Molina & Steven Chu - 66-69 We have the technology
by Katherine Bourzac - 101-101 Fatty liver disease: turning the tide
by Liam Drew - 102-103 Fighting the fatty liver
by Liam Drew - 159-159 Developing nations need more than just money
by Rana Dajani - 165-166 Navajo Nation reconsiders ban on genetic research
by Sara Reardon - 166-167 Scientists plead with Brazilian government to restore funding
by Claudio Angelo - 167-167 Cryo-electron microscopy wins chemistry Nobel
by Daniel Cressey & Ewen Callaway - 168-169 The ambitious effort to document California’s changing deserts
by Amy Maxmen - 169-170 Gene-expression study raises thorny ethical issues
by Ewen Callaway - 172-173 How the United States plans to trap its biggest stash of nuclear-weapons waste in glass
by Jeff Tollefson - 174-177 The rise and fall and rise again of 23andMe
by Erika Check Hayden - 179-181 The future of DNA sequencing
by Eric D. Green & Edward M. Rubin & Maynard V. Olson - 182-184 Build on the outer space treaty
by Joan Johnson-Freese - 185-186 Physics: A classical toolkit
by Malcolm Longair - 186-187 Chemistry: Explosive moments in the laboratory
by Mark Peplow - 187-187 Books in brief
by Barbara Kiser - 188-188 Tap latent source of frugal cancer ideas
by Gauthier Bouche - 188-188 Research that isn't read doesn't exist
by Stephen K. Donovan - 188-188 Risk assessments face legal scrutiny
by Richard Bretton & Willy Aspinall - 188-188 Does the brain control foraging?
by Per Södersten - 188-188 Avoid glib terms of development status
by Khaled Moustafa - 190-191 Cracking the regulatory code
by Michelle C. Ward & Yoav Gilad - 191-192 A pariah finds a home
by Terry Gannon - 192-193 Tumours addicted to drugs are vulnerable
by Rebecca J. Lee & Richard Marais - 194-195 Liquid metal pumped at a record temperature
by Konstantina Lambrinou - 195-197 Receptors identified for a weight regulator
by Mart Saarma & Adrian Goldman - 197-198 Ring detected around a dwarf planet
by Amanda A. Sickafoose - 199-203 Pumping liquid metal at high temperatures up to 1,673 kelvin
by C. Amy & D. Budenstein & M. Bagepalli & D. England & F. DeAngelis & G. Wilk & C. Jarrett & C. Kelsall & J. Hirschey & H. Wen & A. Chavan & B. Gilleland & C. Yuan & W. C. Chueh & K. H. Sandhage & Y. Kawajiri & A. Henry - 214-218 The transcription fidelity factor GreA impedes DNA break repair
by Priya Sivaramakrishnan & Leonardo A. Sepúlveda & Jennifer A. Halliday & Jingjing Liu & María Angélica Bravo Núñez & Ido Golding & Susan M. Rosenberg & Christophe Herman - 219-223 The size, shape, density and ring of the dwarf planet Haumea from a stellar occultation
by J. L. Ortiz & P. Santos-Sanz & B. Sicardy & G. Benedetti-Rossi & D. Bérard & N. Morales & R. Duffard & F. Braga-Ribas & U. Hopp & C. Ries & V. Nascimbeni & F. Marzari & V. Granata & A. Pál & C. Kiss & T. Pribulla & R. Komžík & K. Hornoch & P. Pravec & P. Bacci & M. Maestripieri & L. Nerli & L. Mazzei & M. Bachini & F. Martinelli & G. Succi & F. Ciabattari & H. Mikuz & A. Carbognani & B. Gaehrken & S. Mottola & S. Hellmich & F. L. Rommel & E. Fernández-Valenzuela & A. Campo Bagatin & S. Cikota & A. Cikota & J. Lecacheux & R. Vieira-Martins & J. I. B. Camargo & M. Assafin & F. Colas & R. Behrend & J. Desmars & E. Meza & A. Alvarez-Candal & W. Beisker & A. R. Gomes-Junior & B. E. Morgado & F. Roques & F. Vachier & J. Berthier & T. G. Mueller & J. M. Madiedo & O. Unsalan & E. Sonbas & N. Karaman & O. Erece & D. T. Koseoglu & T. Ozisik & S. Kalkan & Y. Guney & M. S. Niaei & O. Satir & C. Yesilyaprak & C. Puskullu & A. Kabas & O. Demircan & J. Alikakos & V. Charmandaris & G. Leto & J. Ohlert & J. M. Christille & R. Szakáts & A. Takácsné Farkas & E. Varga-Verebélyi & G. Marton & A. Marciniak & P. Bartczak & T. Santana-Ros & M. Butkiewicz-Bąk & G. Dudziński & V. Alí-Lagoa & K. Gazeas & L. Tzouganatos & N. Paschalis & V. Tsamis & A. Sánchez-Lavega & S. Pérez-Hoyos & R. Hueso & J. C. Guirado & V. Peris & R. Iglesias-Marzoa - 224-228 Light-field-driven currents in graphene
by Takuya Higuchi & Christian Heide & Konrad Ullmann & Heiko B. Weber & Peter Hommelhoff - 229-233 Layer-by-layer assembly of two-dimensional materials into wafer-scale heterostructures
by Kibum Kang & Kan-Heng Lee & Yimo Han & Hui Gao & Saien Xie & David A. Muller & Jiwoong Park - 234-238 Patchy particles made by colloidal fusion
by Zhe Gong & Theodore Hueckel & Gi-Ra Yi & Stefano Sacanna - 239-243 The impact of rare variation on gene expression across tissues
by Xin Li & Yungil Kim & Emily K. Tsang & Joe R. Davis & Farhan N. Damani & Colby Chiang & Gaelen T. Hess & Zachary Zappala & Benjamin J. Strober & Alexandra J. Scott & Amy Li & Andrea Ganna & Michael C. Bassik & Jason D. Merker & Ira M. Hall & Alexis Battle & Stephen B. Montgomery - 244-248 Landscape of X chromosome inactivation across human tissues
by Taru Tukiainen & Alexandra-Chloé Villani & Angela Yen & Manuel A. Rivas & Jamie L. Marshall & Rahul Satija & Matt Aguirre & Laura Gauthier & Mark Fleharty & Andrew Kirby & Beryl B. Cummings & Stephane E. Castel & Konrad J. Karczewski & François Aguet & Andrea Byrnes & Tuuli Lappalainen & Aviv Regev & Kristin G. Ardlie & Nir Hacohen & Daniel G. MacArthur - 249-254 Dynamic landscape and regulation of RNA editing in mammals
by Meng How Tan & Qin Li & Raghuvaran Shanmugam & Robert Piskol & Jennefer Kohler & Amy N. Young & Kaiwen Ivy Liu & Rui Zhang & Gokul Ramaswami & Kentaro Ariyoshi & Ankita Gupte & Liam P. Keegan & Cyril X. George & Avinash Ramu & Ni Huang & Elizabeth A. Pollina & Dena S. Leeman & Alessandra Rustighi & Y. P. Sharon Goh & Ajay Chawla & Giannino Del Sal & Gary Peltz & Anne Brunet & Donald F. Conrad & Charles E. Samuel & Mary A. O’Connell & Carl R. Walkley & Kazuko Nishikura & Jin Billy Li - 255-259 Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
by Jer-Yuan Hsu & Suzanne Crawley & Michael Chen & Dina A. Ayupova & Darrin A. Lindhout & Jared Higbee & Alan Kutach & William Joo & Zhengyu Gao & Diana Fu & Carmen To & Kalyani Mondal & Betty Li & Avantika Kekatpure & Marilyn Wang & Teresa Laird & Geoffrey Horner & Jackie Chan & Michele McEntee & Manuel Lopez & Damodharan Lakshminarasimhan & Andre White & Sheng-Ping Wang & Jun Yao & Junming Yie & Hugo Matern & Mark Solloway & Raj Haldankar & Thomas Parsons & Jie Tang & Wenyan D. Shen & Yu Alice Chen & Hui Tian & Bernard B. Allan - 260-264 Hippo pathway deficiency reverses systolic heart failure after infarction
by John P. Leach & Todd Heallen & Min Zhang & Mahdis Rahmani & Yuka Morikawa & Matthew C. Hill & Ana Segura & James T. Willerson & James F. Martin - 265-269 TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
by Manoël Prouteau & Ambroise Desfosses & Christian Sieben & Clélia Bourgoint & Nour Lydia Mozaffari & Davide Demurtas & Alok K. Mitra & Paul Guichard & Suliana Manley & Robbie Loewith - 270-274 Cancer drug addiction is relayed by an ERK2-dependent phenotype switch
by Xiangjun Kong & Thomas Kuilman & Aida Shahrabi & Julia Boshuizen & Kristel Kemper & Ji-Ying Song & Hans W. M. Niessen & Elisa A. Rozeman & Marnix H. Geukes Foppen & Christian U. Blank & Daniel S. Peeper - 275-279 A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis
by Carlos Gorbea & Tim Mosbruger & Demián Cazalla - 280-284 RNA targeting with CRISPR–Cas13
by Omar O. Abudayyeh & Jonathan S. Gootenberg & Patrick Essletzbichler & Shuo Han & Julia Joung & Joseph J. Belanto & Vanessa Verdine & David B. T. Cox & Max J. Kellner & Aviv Regev & Eric S. Lander & Daniel F. Voytas & Alice Y. Ting & Feng Zhang - 285-288 An ace in the hole for DNA sequencing
by Michael Eisenstein - 289-291 Career change: It's never too late to switch
by Amber Dance - 291-291 Writing takes work
by Eli Lazarus - 294-294 Runes transcribed from Dig Site 401A in Ladysmith, Wisconsin
by Rachael K. Jones
October 2017, Volume 550, Issue 7674
- 1-1 Women's health
by Michelle Grayson - 2-3 Sex matters
by Anna Petherick - 4-5 Women's invisible power
by Linda Nordling - 6-8 Sex and the single cell
by Claire Ainsworth - 9-9 Make plans to eliminate cholera outbreaks
by Anita Zaidi - 9-9 Perspective: A heartfelt plea
by Nanette Wenger - 10-11 Early starters
by Jessa Gamble - 12-14 Detecting diversity
by Courtney Humphries - 15-16 Chinese scientists fix genetic disorder in cloned human embryos
by David Cyranoski - 15-17 Staying strong
by Carolyn Brown - 16-17 Ethics of Internet research trigger scrutiny
by Elizabeth Gibney - 17-17 How the latest US travel ban could affect science
by Sara Reardon - 18-18 Medicine Nobel awarded for work on circadian clocks
by Ewen Callaway & Heidi Ledford - 18-19 Inequality in medicine
by Anna Nowogrodzki - 19-19 Gravitational wave detection wins physics Nobel
by Davide Castelvecchi - 20-20 Controversial Thirty Meter Telescope gets go-ahead to build in Hawaii
by Alexandra Witze - 20-23 The United States is failing its mothers
by Lauren Gravitz - 22-24 Why fake islands might be a real boon for science
by Emma Marris - 26-28 How fracking is upending the chemical industry
by Mark Peplow - 29-31 Scientists have most impact when they're free to move
by Cassidy R. Sugimoto & Nicolas Robinson-Garcia & Dakota S. Murray & Alfredo Yegros-Yegros & Rodrigo Costas & Vincent Larivière - 32-33 Open countries have strong science
by Caroline S. Wagner & Koen Jonkers - 34-35 Neuroscience: The mother lode of invention
by Dan Jones - 36-37 Health: The war on germs
by Tilli Tansey - 37-38 Sustainability: China's path to ecotopia
by Xuemei Bai - 38-39 Ornithology: All eyes on the 10,000 species
by Stuart Pimm - 40-41 Theoretical physics: When the doer met the dreamer
by Graham Farmelo - 41-42 Technology: Into cyberia
by Li Gong - 43-43 Hurricanes: rescue natural defences
by Virginie K. E. Duvat & Alexandre K. Magnan - 43-43 Blockchain could boost food security
by Selena Ahmed & Noah ten Broek - 43-43 UNESCO honour for Polish mining facility
by Ryszard Chybiorz & Bogumiła A. Piwowar - 43-43 Heed local impact of coal mining
by Samuel Spiegel & Benjamin Brown - 43-43 Hurricanes: enlist nature's protection
by Timon McPhearson - 46-47 Zapping viral RNAs
by Stephen P. Goff - 47-48 Material change for X-ray detectors
by John A. Rowlands - 48-49 A global plan for nature conservation
by James E. M. Watson & Oscar Venter - 49-51 Big science in a small country
by Nic Fleming - 50-51 Computational design hits record resolution
by Matthijs Langelaar - 51-52 A matter of time for tropical diversity
by Gary G. Mittelbach - 53-60 Expanding and reprogramming the genetic code
by Jason W. Chin - 61-66 Strains, functions and dynamics in the expanded Human Microbiome Project
by Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDonald & Eric A. Franzosa & Rob Knight & Owen White & Curtis Huttenhower - 67-73 Genome editing reveals a role for OCT4 in human embryogenesis
by Norah M. E. Fogarty & Afshan McCarthy & Kirsten E. Snijders & Benjamin E. Powell & Nada Kubikova & Paul Blakeley & Rebecca Lea & Kay Elder & Sissy E. Wamaitha & Daesik Kim & Valdone Maciulyte & Jens Kleinjung & Jin-Soo Kim & Dagan Wells & Ludovic Vallier & Alessandro Bertero & James M. A. Turner & Kathy K. Niakan - 74-79 Massively parallel de novo protein design for targeted therapeutics
by Aaron Chevalier & Daniel-Adriano Silva & Gabriel J. Rocklin & Derrick R. Hicks & Renan Vergara & Patience Murapa & Steffen M. Bernard & Lu Zhang & Kwok-Ho Lam & Guorui Yao & Christopher D. Bahl & Shin-Ichiro Miyashita & Inna Goreshnik & James T. Fuller & Merika T. Koday & Cody M. Jenkins & Tom Colvin & Lauren Carter & Alan Bohn & Cassie M. Bryan & D. Alejandro Fernández-Velasco & Lance Stewart & Min Dong & Xuhui Huang & Rongsheng Jin & Ian A. Wilson & Deborah H. Fuller & David Baker - 80-83 A hybrid type Ia supernova with an early flash triggered by helium-shell detonation
by Ji-an Jiang & Mamoru Doi & Keiichi Maeda & Toshikazu Shigeyama & Ken’ichi Nomoto & Naoki Yasuda & Saurabh W. Jha & Masaomi Tanaka & Tomoki Morokuma & Nozomu Tominaga & Željko Ivezić & Pilar Ruiz-Lapuente & Maximilian D. Stritzinger & Paolo A. Mazzali & Christopher Ashall & Jeremy Mould & Dietrich Baade & Nao Suzuki & Andrew J. Connolly & Ferdinando Patat & Lifan Wang & Peter Yoachim & David Jones & Hisanori Furusawa & Satoshi Miyazaki - 84-86 Giga-voxel computational morphogenesis for structural design
by Niels Aage & Erik Andreassen & Boyan S. Lazarov & Ole Sigmund - 87-91 Printable organometallic perovskite enables large-area, low-dose X-ray imaging
by Yong Churl Kim & Kwang Hee Kim & Dae-Yong Son & Dong-Nyuk Jeong & Ja-Young Seo & Yeong Suk Choi & In Taek Han & Sang Yoon Lee & Nam-Gyu Park - 92-95 A solvent- and vacuum-free route to large-area perovskite films for efficient solar modules
by Han Chen & Fei Ye & Wentao Tang & Jinjin He & Maoshu Yin & Yanbo Wang & Fengxian Xie & Enbing Bi & Xudong Yang & Michael Grätzel & Liyuan Han - 96-100 A spin transition mechanism for cooperative adsorption in metal–organic frameworks
by Douglas A. Reed & Benjamin K. Keitz & Julia Oktawiec & Jarad A. Mason & Tomče Runčevski & Dianne J. Xiao & Lucy E. Darago & Valentina Crocellà & Silvia Bordiga & Jeffrey R. Long - 101-104 Delta progradation in Greenland driven by increasing glacial mass loss
by Mette Bendixen & Lars Lønsmann Iversen & Anders Anker Bjørk & Bo Elberling & Andreas Westergaard-Nielsen & Irina Overeem & Katy R. Barnhart & Shfaqat Abbas Khan & Jason E. Box & Jakob Abermann & Kirsty Langley & Aart Kroon - 105-108 Temporal coexistence mechanisms contribute to the latitudinal gradient in forest diversity
by Jacob Usinowicz & Chia-Hao Chang-Yang & Yu-Yun Chen & James S. Clark & Christine Fletcher & Nancy C. Garwood & Zhanqing Hao & Jill Johnstone & Yiching Lin & Margaret R. Metz & Takashi Masaki & Tohru Nakashizuka & I-Fang Sun & Renato Valencia & Yunyun Wang & Jess K. Zimmerman & Anthony R. Ives & S. Joseph Wright - 109-113 Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity
by Brian O. Orr & Richard D. Fetter & Graeme W. Davis - 114-118 A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
by Ulrich Elling & Reiner A. Wimmer & Andreas Leibbrandt & Thomas Burkard & Georg Michlits & Alexandra Leopoldi & Thomas Micheler & Dana Abdeen & Sergei Zhuk & Irene M. Aspalter & Cornelia Handl & Julia Liebergesell & Maria Hubmann & Anna-Maria Husa & Manuela Kinzer & Nicole Schuller & Ellen Wetzel & Nina van de Loo & Jorge Arturo Zepeda Martinez & David Estoppey & Ralph Riedl & Fengtang Yang & Beiyuan Fu & Thomas Dechat & Zoltán Ivics & Chukwuma A. Agu & Oliver Bell & Dieter Blaas & Holger Gerhardt & Dominic Hoepfner & Alexander Stark & Josef M. Penninger - 119-123 Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
by Christina D. Camell & Jil Sander & Olga Spadaro & Aileen Lee & Kim Y. Nguyen & Allison Wing & Emily L. Goldberg & Yun-Hee Youm & Chester W. Brown & John Elsworth & Matthew S. Rodeheffer & Joachim L. Schultze & Vishwa Deep Dixit - 124-127 CG dinucleotide suppression enables antiviral defence targeting non-self RNA
by Matthew A. Takata & Daniel Gonçalves-Carneiro & Trinity M. Zang & Steven J. Soll & Ashley York & Daniel Blanco-Melo & Paul D. Bieniasz - 128-132 Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
by Loren M. Lasko & Clarissa G. Jakob & Rohinton P. Edalji & Wei Qiu & Debra Montgomery & Enrico L. Digiammarino & T. Matt Hansen & Roberto M. Risi & Robin Frey & Vlasios Manaves & Bailin Shaw & Mikkel Algire & Paul Hessler & Lloyd T. Lam & Tamar Uziel & Emily Faivre & Debra Ferguson & Fritz G. Buchanan & Ruth L. Martin & Maricel Torrent & Gary G. Chiang & Kannan Karukurichi & J. William Langston & Brian T. Weinert & Chunaram Choudhary & Peter de Vries & Arthur F. Kluge & Michael A. Patane & John H. Van Drie & Ce Wang & David McElligott & Ed Kesicki & Ronen Marmorstein & Chaohong Sun & Philip A. Cole & Saul H. Rosenberg & Michael R. Michaelides & Albert Lai & Kenneth D. Bromberg - 133-136 PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
by Hezhe Lu & Shujing Liu & Gao Zhang & Bin Wu & Yueyao Zhu & Dennie T. Frederick & Yi Hu & Wenqun Zhong & Sergio Randell & Norah Sadek & Wei Zhang & Gang Chen & Chaoran Cheng & Jingwen Zeng & Lawrence W. Wu & Jie Zhang & Xiaoming Liu & Wei Xu & Clemens Krepler & Katrin Sproesser & Min Xiao & Benchun Miao & Jianglan Liu & Claire D. Song & Jephrey Y. Liu & Giorgos C. Karakousis & Lynn M. Schuchter & Yiling Lu & Gordon Mills & Yusheng Cong & Jonathan Chernoff & Jun Guo & Genevieve M. Boland & Ryan J. Sullivan & Zhi Wei & Jeffrey Field & Ravi K. Amaravadi & Keith T. Flaherty & Meenhard Herlyn & Xiaowei Xu & Wei Guo - 137-141 How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration
by Yibei Xiao & Sherwin Ng & Ki Hyun Nam & Ailong Ke - 142-142 Correction: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet
by Andrew G. Levine & Alejandra Mendoza & Saskia Hemmers & Bruno Moltedo & Rachel E. Niec & Michail Schizas & Beatrice E. Hoyos & Ekaterina V. Putintseva & Ashutosh Chaudhry & Stanislav Dikiy & Sho Fujisawa & Dmitriy M. Chudakov & Piper M. Treuting & Alexander Y. Rudensky - 142-142 Correction: Corrigendum: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
by Weiwei Yang & Yan Xia & Haitao Ji & Yanhua Zheng & Ji Liang & Wenhua Huang & Xiang Gao & Kenneth Aldape & Zhimin Lu - 142-142 Correction: Corrigendum: High-temperature crystallization of nanocrystals into three-dimensional superlattices
by Liheng Wu & Joshua J. Willis & Ian Salmon McKay & Benjamin T. Diroll & Jian Qin & Matteo Cargnello & Christopher J. Tassone - 143-144 Collaborative software development made easy
by Andrew Silver - 145-147 The secrets of a standout seminar
by Amber Dance - 147-147 Societies reconsider conference plans
by Chris Woolston - 150-150 The daughter you've always wanted
by Steve Pantazis
September 2017, Volume 549, Issue 7673
- 11-11 Blood
by Herb Brody - 12-15 Bioengineering: Doing without donors
by Elie Dolgin - 16-18 Diagnosis: Frontiers in blood testing
by Emily Sohn - 19-21 Screening: In the blood
by Cassandra Willyard - 22-23 Transfusion: Too much of a good thing
by Bianca Nogrady - 24-25 Criminology: Written in blood
by Sujata Gupta - 26-27 Neuroscience: The power of plasma
by Liam Drew - 28-30 Gene therapy: Erasing sickle-cell disease
by Katherine Bourzac - 61-61 Drilling for excellence
by Richard Hodson - 64-68 Reaping knowledge: A world away
by Sedeer El-Showk - 70-74 The gender divide: Agents of change
by Louise Sarant - 75-77 Call for an industrial-grade overhaul
by Nadia El-Awady - 433-433 Don’t let disaster recovery perpetuate injustice
by Benjamin K. Sovacool - 439-440 Hurricanes Harvey and Irma send scientists scrambling for data
by Rachael Lallensack - 440-441 High-energy cosmic rays come from outside our Galaxy
by Davide Castelvecchi - 441-441 What Germany’s election results mean for science
by Quirin Schiermeier & Alison Abbott - 442-442 Deadly Mexico quakes not linked
by Alexandra Witze - 443-443 Giant iceberg’s split exposes hidden ecosystem
by Jo Marchant - 443-444 Sexual competition among ducks wreaks havoc on penis size
by Amy Maxmen - 445-447 The drug-maker's guide to the galaxy
by Asher Mullard - 448-450 A quantum pioneer unlocks matter’s hidden secrets
by Elizabeth Gibney - 451-453 Three ways to make proton therapy affordable
by Thomas R. Bortfeld & Jay S. Loeffler