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Content
December 2026, Volume 17, Issue 1
- 1-23 Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
by Sabrina Pia Nuccio & Enrico Cadoni & Roxani Nikoloudaki & Silvia Galli & An-Jie Ler & Claudia Sanchez-Cabanillas & Thomas E. Maher & Ella Fan & Dilek Guneri & Gem Flint & Minghui Zhu & Ling Sum Liu & Christopher R. Fullenkamp & Zoë Waller & Luca Magnani & John S. Schneekloth Jr & Marco Di Antonio - 1-23 Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration
by Shasha Li & Hui Liu & Shao-Hui Pan & Zhengbiao Zhu & Shun Zhang & Jiahang Li & Yinghao Yao & Xinyu Wang & Na Gao & Xiaoyu Liu & Ming Chen & Huijuan Hu & Wenmin Pan & Qunyan Zhu & Yaoyao Cai & Jia Qu & Shaorong Gao & Jianzhong Su - 1-23 Comprehensive discovery of m6A sites in the human transcriptome at single-molecule resolution
by Gihyeon Kang & Hyeonseo Hwang & Hyeonseong Jeon & Heejin Choi & Hee Ryung Chang & Nagyeong Yeo & Junehee Park & Narae Son & Eunkyeong Jeon & Jungmin Lim & Jaeung Yun & Wook Choi & Jae-Yoon Jo & Jong-Seo Kim & Sangho Park & Yoon Ki Kim & Daehyun Baek - 1-23 Molecular signatures of resilience to Alzheimer’s disease in neocortical layer 4 neurons
by S. Akila Parvathy Dharshini & Jorge Sanz-Ros & Jie Pan & Weijing Tang & Kristen Vallejo & Yu Chen Liu & Marcos Otero-Garcia & Inma Cobos - 1-23 Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC
by Subhamoy Chakraborty & Andrew Elliott & Utsav Sen & Charles Coleman & Vrinda Jethalia & Kedwin Ventura & Chih-Wei Fan & Ramja Sritharan & Avisek Banerjee & Yazhini Mahendravarman & Ari Vanderwalde & Balazs Halmos & Elisa de Stanchina & Hirokazu Taniguchi & Deniz Demircioglu & Dan Hasson & Triparna Sen - 1-23 Charting spatial ligand-target activity using Renoir
by Narein Rao & Tanush Kumar & Dina Kazemi & Shaozhi Hou & Atefeh Khakpoor & Merrin Mary Eapen & Rhea Pai & Liang Qiao & Archita Mishra & Florent Ginhoux & Jerry Kok Yen Chan & Jacob George & Ankur Sharma & Hamim Zafar - 1-23 GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum
by Danushka S. Marapana & Sash Lopaticki & Balu Balan & Kitsanapong Reaksudsan & Simon A. Cobbold & Niall D. Geoghegan & Sachin Khurana & Stephen W. Scally & Peter Hickey & Niva Jayakrishnan & Vineet Vaibhav & Sukhdeep Spall & Jumana M. Yousef & Laura F. Dagley & Christopher D. Goodman & Anton Cozijnsen & Geoffrey I. McFadden & Kelly L. Rogers & Aaron Jex & David Komander & James S. McCarthy & Christopher J. Tonkin & Matthew W. A. Dixon & Alan F. Cowman - 1-23 Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks
by Paris Mazzachi & Ella McDonald & Zarina Greenberg & Alejandra Noreña Puerta & Jenne Tran & Manam Inushi De Silva & Cade Christensen & Robert Adams & Sebastian Loskarn & Helen Beard & Michael Zabolocki & Meera Elmasri & Megan Maack & Kristina L. Elvidge & Mark R. Hutchinson & Cara O’Neill & Kim M. Hemsley & Lisa Melton & Nicholas Smith & Cedric Bardy - 1-23 Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State
by Yusuke Tsutsui & Atsushi Masui & Satoshi Konishi & Taro Tsujimura & Mio Iwasaki & Takuya Yamamoto & Shimpei Gotoh - 1-23 Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation
by Hok Ning Tsui & Charmaine Yan Yu Wong & Chaogu Zheng & Karen Wing Yee Yuen - 1-23 Modeling attention and binding in the brain through bidirectional recurrent gating
by Saeed Salehi & Jordan Lei & Ari S. Benjamin & Klaus-Robert Müller & Konrad P. Kording - 1-23 Backpropagation through space, time and the brain
by Benjamin Ellenberger & Paul Haider & Federico Benitez & Jakob Jordan & Kevin Max & Ismael Jaras & Laura Kriener & Mihai A. Petrovici - 1-23 Functional implications of polygenic risk for schizophrenia in human neurons
by PJ Michael Deans & Kayla G. Retallick-Townsley & Aiqun Li & Carina Seah & Jessica Johnson & Judit Garcia Gonzalez & Evan Cao & Nadine Schrode & Alex Yu & Sam Cartwright & Georgios Voloudakis & Wen Zhang & Minghui Wang & John F. Fullard & Kiran Girdhar & Eli Stahl & Schahram Akbarian & Bin Zhang & Panos Roussos & Paul O’Reilly & Laura M. Huckins & Kristen J. Brennand - 1-23 The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase
by Ana Martín-Hurtado & Julia Contreras & Jana Sánchez-Wandelmer & Eduardo Zarzuela & Fernando García & Johanne Le Coq & Jasminka Boskovic & Inés G. Muñoz & Federico Gago & Javier Muñoz & Marta Isasa & Iván Plaza-Menacho - 1-23 Maturase K forms a plastidial splicing complex with a neofunctionalized branching enzyme
by Yuanyuan Liang & Yang Gao & Andrea Fontana & Melanie Abt & Adam Gicgier & Muriel Gehring & Chun Liu & Mayank Sharma & Reimo Zoschke & Samuel C. Zeeman & Barbara Pfister - 1-23 GPR4 promotes immune exclusion in colon cancer through LOXL2-mediated extracellular matrix remodeling
by Shuheng Bai & Min Chen & Xuan Wang & Ning Lan & Ruijie Meng & Yanli Yan & Wanyi Liu & Wenyang Li & Fang Wu & Xiangxiang Zhang & Fengyuan Hu & Rong Li & Juan Ren - 1-23 Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration
by Shai Kaluski-Kopatch & Daniel Stein & Alfredo Garcia Venzor & Ana Margarida Ferreira Campos & Melanie Planque & Bareket Goldstein & Estefanía De Allende-Becerra & Dmitrii Smirnov & Adam Zaretsky & Ekaterina Eremenko & Miguel Portillo & Monica Einav & Alena Bruce Krejci & Uri Abdu & Ekaterina Khrameeva & Daniel Gitler & Sarah-Maria Fendt & Debra Toiber - 1-23 In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy
by Yue Chen & Qinyi Chen & Yuanyuan Ma & Cheng Zhang & Jie Xu & Kejing Li & Yajie Sun & Xinge Su & Mingguang Wei & Rui Bao & Tong Ding & Longguang Tang & Wenying Yu & Shenghong Ju & Wenpei Fan - 1-23 A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses
by Samy Sid Ahmed & Liv Zimmermann & Andrea Imle & Katrin Wuebben & Nadine Tibroni & Lena Rauch-Wirth & Jan Münch & Petr Chlanda & Frederik Graw & Oliver T. Fackler - 1-23 High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infection
by Cong Han & Yongqi Wang & Shihuan Gao & Ting Wang & Huili Du & Jie Long & Weidong Tian & Mohsen Adeli & Liang Cheng & Zhi Liu & Tian Chen & Chong Cheng - 1-23 Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program
by Nana Zhang & Ran Zhao & Xiaomin Zhong & Qian Dong & Yajie Liu & Kairan Yu & Lirui Han & Fanxu Meng & Jiaxuan Wu & Qiushi Chen & Xuechen Li & Qingbin Chen & Keren Zhang & Huang Huang & Jianing Zhang & Sijin Wu & Yan Ren & Wei Wang & Yubo Liu - 1-23 Analysis of medieval burials from Ibiza reveals genetic and pathogenic diversity during the Islamic period
by Ricardo Rodríguez-Varela & Zoé Pochon & Alex Mas-Sandoval & Reyhan Yaka & Cesar A. Fortes-Lima & Almudena García Rubio & Nicholas Márquez-Grant & Juanjo Marí & Glenda Graziani & Antoni Ferrer Abárzuza & Mário Vicente & Lander Lorca-Francisco & Anna Linderholm & Vendela K. Lagerholm & Lara R. Arauna & Patxi Pérez-Ramallo & Maja Krzewińska & Carina M. Schlebusch & Anders Götherström - 1-23 Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment
by Peng Cao & Qilin Li & Yuyu Li & Honglian Guo & Chunyu Wei & Rengui Xu & Chenke Ouyang & Wei Chen & Lin Wang & Zheng Wang - 1-23 Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm
by Joanna Szpotkowska & Wojciech J. Szlachcic & Katarzyna Blaszczyk & Maja Baginska & Magdalena Socha & Malgorzata Borowiak - 1-23 Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy
by Winnie Fernando & Jarama Clucas & Alberto Rizzo & Ramsay Singer & Emily Goode & Crescens Tiu & Scott Layzell & Joshua Konecnik & Rebecca Wilson & Sidonie Wicky John & Samuel Jouny & Naomi Guppy & Victoire Boulat & Jonathan Mannion & Maria Goicoechea & Shaun Tan & Sam Lawson & Chris Starling & Gabrielle Elshtein & Nivedita Ravindran & Anna B. Montgomery & Rosa Andres-Ejarque & Mark Allen & Steven Lumbard & Fredrik Wallberg & Kai Betteridge & Ross Scrimgeour & David Robertson & George Ward & Martin Sims & Tomoko Smyth & Andre L. Samson & James M. Murphy & Daniela Kolarevic Ivankovic & Esther N. Arwert & Dinis P. Calado & Anita Grigoriadis & Matthew J. Smalley & Alan Melcher & Syed Haider & Toby Lawrence & Ioannis Roxanis & Andrew N. J. Tutt & Tencho Tenev & Pascal Meier - 1-23 Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
by Sathish Babu Vasamsetti & Samreen Sadaf & Mohammad A. Uddin & Jixing Shen & Ebin Johny & Awishi Mondal & Jonathan Florentin & Liqun Lei & Aleef Mannan & Krithika Sudhakar Rao & John Sembrat & Mauricio Rojas & Ian Sipula & Jake Kastroll & Michael J. Jurczak & Sruti Shiva & Robert M. O’Doherty & Vijay Yechoor & Partha Dutta - 1-23 Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2
by Sam E. J. Paton & José L. Solano & Alice Cadoret & Adeline Collignon & Luisa Bandeira Binder & Béatrice Daigle & Laura Menegatti Bevilacqua & Émanuelle Richer & François Coulombe-Rozon & Laurence Dion-Albert & Katarzyna A. Dudek & Manon Lebel & Caroline Ménard - 1-23 Gene expression dynamics of human and mouse craniofacial development at the single-cell level
by Nagham Khouri-Farah & Alexandra Manchel & Emma Wentworth Winchester & Brian M. Schilder & Kelsey Robinson & Sarah W. Curtis & Nathan G. Skene & Elizabeth J. Leslie-Clarkson & Justin Cotney - 1-23 Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression
by Vincent Cuminetti & Emeline Boet & Marcel Heugel & Joanna Konieczny & Aurora Bernal & Manuel J. Gomez & Franco Grimolizzi & Nuria Vilaplana-Lopera & Marc Ferré & Alicia Villatoro & Deo P. Pandey & Carlos Torroja & Hagar Taman & Ruth H. Paulssen & Thomas Vogl & Caroline A. Heckman & Anders Vik & Giovanna Giovinazzo & Nick van Gastel & Paloma García & Fátima Sánchez-Cabo & Jean-Emmanuel Sarry & Lorena Arranz - 1-23 Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state
by Ludivine Bersier & L. Francisco Lorenzo-Martin & Yi-Hsuan Chiang & Stephan Durot & Aleksander Czauderna & Tural Yarahmadov & Tania Wyss Lozano & Irena Roci & Jaeryung Kim & Nicola Zamboni & Nicola Vannini & Caroline Pot & Tinh-Hai Collet & Deborah Stroka & Jeremiah Bernier-Latmani & Matthias P. Lutolf & Simone Becattini & Thibaud Koessler & Tatiana V. Petrova - 1-23 Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming
by Mark Rusznak & Shinji Toki & Yajing Hao & Marc J. C. Todd & Liddy Malone & Julia F. Goodhead & Catherine DuPuy & Weisong Zhou & Dominique Babin & Christian M. Warren & Masako Abney & Matthew T. Stier & Christopher M. Thomas & Jing Li & Justin Jacobse & Andrew P. Pahnke & Mark I. Petrovic & Jacqueline-Yvonne Cephus & Shelby N. Kuehnle & M. Wade Calcutt & Allison E. Norlander & Fang Yan & Jeremy A. Goettel & Darla R. Miller & Rachel M. Lynch & Daniel P. Cook & Dawn C. Newcomb & Fei Zou & R. Stokes Peebles Jr - 1-23 AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria
by Markus Janetzky & Norman Geist & Sabrina Schulze & Henriette Rückert & Kimani Gatzemeyer & Gottfried J. Palm & Leona Berndt & Britta Girbardt & Daniel Weis & Ina Menyes & Norma Welsch & Thomas Schweder & Mark Dörr & Stefan Kemnitz & Uwe T. Bornscheuer & Mihaela Delcea & Michael Lammers - 1-23 Discovering the complete enhancer map of human herpesviruses using a natural language processing model
by Nilabja Roy Chowdhury & Deepanway Ghosal & Vyacheslav Gurevich & Meir Shamay - 1-23 Comparative multi-omic analysis reveals conserved and derived mechanisms of fin and limb regeneration
by Josane F. Sousa & Gabriela Lima & Louise Perez & Hannah Schof & Igor Schneider - 1-23 Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam
by Philipp Kruppa & Rachelle Crescenzi & Gabriele Faerber & Isabel Forner-Cordero & Manuel Cornely & Ramin Shayan & Tara Karnezis & Jose Luis Simarro & Paula Frederichi de Souza & Karen Louise Herbst & Mojtaba Ghods & Sandro Michelini - 1-23 Fc-free single-chain antibody mRNA therapy for airway infection of multidrug-resistant Pseudomonas aeruginosa
by Mao Kinoshita & Ken Kawaguchi & Yuki Mochida & Nguyen B. T. Le & Atsushi Kainuma & Naoko Takeda-Miyata & Motohiro Kojima & Teiji Sawa & Satoshi Uchida - 1-23 Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice
by Yawen Li & Hui Wang & Dongyuan Zhang & Shiqi Wang & Zheng Li & Jingjie Li & Shentao Tai & Dandan Tong & Bifeng Wang & Dingbing Lu & Shulu Yuan & Weiqi Sun & Biyu Yang & Chaobo Bai & Qi Wang & Jiuyang Ding & Zhihao Wang & Yang Gao & Haitao Yu & Kun Cui & Chang Liu & Jian Mao & Yun Yao & Fengyu Liu & You Wan & Junliang Yuan & Xuemei Liu & Jie Zheng - 1-23 Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling
by Kristine J. Fernandez & Ghazal Sultani & Max Nobis & Brian Gloss & Leila Eshraghi & Amy E. McCart Reed & Sarah Alexandrou & Christine Lee & Daniel L. Roden & Emily I. Jones & Maryam Hasha Simad & Ewan K. A. Millar & Nenad Bartonicek & Samantha R. Oakes & Fatima Valdes-Mora & Yolanda Colino-Sanguino & Ellie T. Y. Mok & Hannah L. Williams & Jamie R. Kutasovic & Margaret C. Cummings & Janett Stoehr & Victoria Lee & Kate Harvey & Sunny Wu & Sunil R. Lakhani & Peter T. Simpson & Thomas R. Cox & Lisa M. Ooms & Christina A. Mitchell & Rob Salomon & Alexander Swarbrick & David Gallego-Ortega & Elgene Lim & Paul Timpson & C. Elizabeth Caldon - 1-23 Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer
by Pratishtha Singh & Ranit D’Rozario & Bidisha Chakraborty & Swadhin Meher & Deblina Raychaudhuri & Aminah J. Tannir & Yang Li & Anurag Majumdar & Jessalyn Hawkins & Yun Xiong & Philip Lorenzi & Padmanee Sharma & Kadir Akdemir & Patrick Pilie & Abhinav K. Jain & Byron Hing Lung Lee & Sangeeta Goswami - 1-23 RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
by Chi Yan & Weifeng Luo & Jinming Yang & Jing Yang & Sheau-Chiann Chen & Kensey Bergdorf & Qianni Hu & Vivian L. Weiss & Douglas B. Johnson & Qi Liu & Ann Richmond - 1-23 Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis
by Huige Lin & Melody Yuen Man Ho & Baomin Wang & Shama Mansoori & Yumei Yang & Wen Wang & Pui Kin So & Aimin Xu & Shilun Yang & Junlei Chang & Ada Man Hau Man & Hailong Piao & Chen Gao & Parco Ming Fai Siu & Xiaomu Li & Kenneth King Yip Cheng - 1-23 Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator
by Mriga Dutt & Luoping Liao & Hani Jieun Kim & Ronnie Blazev & Audrey Chan & Hitesh Kore & Ayenachew Bezawork-Geleta & Li Dong & Isela Sarahi Rivera & Natalie K. Y. Wee & Jeffrey Molendijk & Julian P. H. Wong & Vanessa R. Haynes & Veronica Uribe & Gordon S. Lynch & Kelly A. Smith & Magdalene K. Montgomery & Matthew J. Watt & Pengyi Yang & Garron T. Dodd & Stephin J. Vervoort & Natalie A. Sims & Benjamin L. Parker - 1-23 Versican expression from lung fibroblasts suppresses pulmonary fibrosis
by Paraskevi Kanellopoulou & Ilianna Barbayianni & Dionysios Fanidis & Martina Samiotaki & Eleni Katsiouli & Dimitris Nastos & Stefanos Smyrniotis & Maria Shira & Apostolos Galaris & Vagelis Rinotas & Sofia Grammenoudi & Christiana Magkrioti & Ioannis Tomos & Africa Martinez Blanco & Ioanna Tremi & Ioannis Vamvakaris & Nuria Gavara & Sophia Havaki & Vassilis Gorgoulis & Hideto Watanabe & Vassilis Aidinis - 1-23 Recurrent connections facilitate occluded object recognition by explaining-away
by Byungwoo Kang & Benjamin Midler & Feng Chen & Shaul Druckmann - 1-24 FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing
by Pierre Parutto & Yutong Yuan & Valentina Davì & Roger Pons-Lanau & Svenja Ebeling & Karnika Gupta & Francesca Bottanelli & Maria F. Garcia-Parajo & Felix Campelo & Clemens F. Kaminski & Joseph E. Chambers & Jonathon Nixon-Abell & Edward Avezov - 1-24 A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation
by Isabel Stötzel & Ann-Kathrin Weier & Apurba Sarkar & Subhendu Som & Luisa Bach & Peter Konopka & Eliška Miková & Shaunak Ghosh & Jan Böthling & Mirka Homrich & Laura Schaedel & Uli Kazmaier & Konstantinos Symeonidis & Stefan Ebner & Philip Weidner & Zeinab Abdullah & Felix Meissner & Stefan Uderhardt & Miroslav Hons & Dirk Baumjohann & Raja Paul & Heiko Rieger & Eva Kiermaier - 1-24 Large-scale multi-omics profiling reveals environmental and evolutionary drivers of fungal phylogeographic and metabolic diversity
by Huali Xie & Jie Hu & Xiulan Zhao & Jianwei Chen & Xiaofeng Yue & Changhao Zhou & Jorge C. Navarro-Muñoz & Jun Jiang & Xiaoqian Tang & Fang Zhao & E. Anne Hatmaker & Antonis Rokas & Amelia E. Barber & Milton T. Drott & Nancy P. Keller & Qi Zhang & Justin J. J. van der Hooft & Marnix H. Medema & Peiwu Li - 1-24 Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina
by Bhakta Prasad Gaire & Yosef Koronyo & Jean-Philippe Vit & Alexandre Hutton & Lalita Subedi & Dieu-Trang Fuchs & Natalie Swerdlow & Altan Rentsendorj & Saba Shahin & Daisy Martinon & Edward Robinson & Alexander V. Ljubimov & Julie A. Schneider & Lon S. Schneider & Debra Hawes & Stuart L. Graham & Vivek K. Gupta & Mehdi Mirzaei & Keith L. Black & Jesse G. Meyer & Moshe Arditi & Timothy R. Crother & Maya Koronyo-Hamaoui - 1-24 Combinatory differentiation of human induced pluripotent stem cells generates functional thymic epithelium driving dendritic cell and CD4/CD8 T cell development
by Nathan Provin & Manon d’Arco & Antoine Le Bozec & Erwan Kervagoret & Alexandre Bruneau & Lucas Brusselle & Cynthia Fourgeux & Jeremie Poschmann & Philippe Hulin & Pierre Maminirina & Olivier Baron & Xavier Saulquin & Carole Guillonneau & Laurent David & Matthieu Giraud - 1-24 LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC
by Takumitsu Machida & Yingbo Gong & Sayaka Tsukioka & Atsushi Onodera & Akitoshi Nakayama & Naoko Hashimoto & Takahiro Fuchigami & Motoi Nishimura & Tomohiro Ogino & Ryota Kurimoto & Yasufumi Uematsu & Hidemi Suzuki & Hongye Yu & Mingyang Chen & Masataka Yokoyama & Ikki Sakuma & Yuki Taki & Takashi Kono & Takashi Miki & Shinichiro Motohashi & Yusuke Kawashima & Osamu Ohara & Satoshi Yamashita & Tatsuya Suzuki & Ryo Hatanaka & Yasuo Kodama & Shuichi Ohkubo & Tomoaki Tanaka - 1-24 Palmitic acid-triggered B7H3 palmitoylation promotes immune escape
by Zejun Rao & Changsheng Huang & Qi Wu & Mao Li & Anyi Liu & Tong Zhu & Wangshuo Yang & Lanlan Yin & Shengyu Zhu & Xiaowei She & Chengxin Yu & Lang Liu & Pengcheng Li & Yucong Bai & Dongjing Zhang & Tianci Xie & Xiang Liu & Lu Liu & Feng Xu & Guihua Wang & Junbo Hu & Xuelai Luo - 1-24 Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration
by Nikolaos Tsopoulidis & Masaki Yagi & Justin Brumbaugh & Shinya Ito & Víctor López-Soriano & Robert Morris & Yoseop Yoon & Kathleen A. Messemer & Kuan-Hung Lin & Eric F. Zaniewski & Rebecca Gorelov & Aaron J. Huebner & Amy J. Wagers & Hanno Hock & Günter Kramer & Bernd Bukau & Michael S. Hoetker & Yongsheng Shi & Wilhelm Haas & Konrad Hochedlinger - 1-24 Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway
by Ziqi Zhang & Xue li & Tianqi Lu & Jingyun Yang & Xuejiao Han & Zhenfei Bi & Jingwen Luo & Aqu Alu & Weiqi Hong & Siyuan Chen & Lei Chen & Yuan Cheng & Xuemei He & Chenjing Zhu & Manni Wang & Qingfang Li & Yang Wang & Lu Li & Hong Lei & Jie Lan & Jia Geng & Yuquan Wei & Xiawei Wei - 1-24 Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer
by Jia-Jia Zhang & Ruo-Fei Tian & Chang-Geng Song & Rui Liu & Duo He & Gai-Qin Zhang & Xin-Yu Fan & Zi-Chuan Duan & Kun Zhang & Tian-Jiao Zhang & Ya-Tong Chen & Jian Zhang & Ke Wang & Ju-Mei Zhao & Xiang-Min Yang & Zhi-Nan Chen & Ling Li - 1-24 Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex
by Rakenduvadhana Szrinivasan & Kalevi Trontti & Rémi Mathieu & Tangra Draia-Nicolau & Genevieve Chazal & Säde Loukasmäki & Silvana Bodington Celma & Kaia Achim & Pavel Uvarov & Stanislav Khirug & Anastasia Ludwig & Sari E. Lauri & Antoine de Chevigny & Olli Pietiläinen & Claudio Rivera - 1-24 Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair
by Minjun Kwak & Eunjun Choi & Yemin Jo & Boa Kim & Chaeryeong Lim & Jooyoung Lim & Yoon Ha Choi & Jung Hyun Lee & Kee-Pyo Kim & Bon-Kyoung Koo & Jong Kyoung Kim & Sekyu Choi - 1-24 DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis
by Umar K. Khan & Ayush Goel & Shivansh Nigam & Nazia Chaudhary & Ayush Praveen & Anjan Roy & Fabeha Fatima & Dilpreet K. Sawhney & Afiya Dalwai & Akshay Shendre & Shannon Carskadon & Anjali Bajpai & Abhimanyu Kapoor & Anjali Tewari & Abhijit Chandra & Avanish Saklani & Sorab N. Dalal & Nallasivam Palanisamy & Bushra Ateeq - 1-24 The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization
by Giulia Baracchini & Yigu Zhou & Jason da Silva Castanheira & Justine Y. Hansen & Can Fenerci & Roni Setton & Jenny R. Rieck & Gary R. Turner & Cheryl L. Grady & Bratislav Misic & Jason S. Nomi & Lucina Q. Uddin & R. Nathan Spreng - 1-24 Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions
by Yuxiang Liang & Zhaowei Yu & Shaobo Du & Yuqian Guo & Jing Li & Yujia Yan & Shanshan Jin & Wenjing Liang & Mengyuan Li & Ning Jin & Jiao Yang & Zhiwei Peng & Zhaoyang Chen & Hailan Yang & Zhizhen Liu & Qizhi Shuai & Liping Li & Jun Xie - 1-24 Neural circuit models for evidence accumulation through choice-selective sequences
by Lindsey S. Brown & Jounhong Ryan Cho & Scott S. Bolkan & Edward H. Nieh & Manuel Schottdorf & David W. Tank & Carlos D. Brody & Ilana B. Witten & Mark S. Goldman - 1-24 Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
by Irene Schwartz & Valentina Budroni & Mathilde Meyenberg & Zuzana Hodakova & Harald Hornegger & Kathrin Hacker & Siegfried Schwartz & Daniel B. Grabarczyk & Julian F. Ehrmann & Sara Scinicariello & David Haselbach & Jörg Menche & Tim Clausen & G. Elif Karagöz & Gijs A. Versteeg - 1-24 Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex
by Juan Meng & Cheng Chen & Zhiyong Zhu & Yongkang Sun & Yiming Huang & Kaijie Hu & Jiqiang Fu & Luyan Wu & Ling Li & Yiqin Bai & Tianyi Fei & Zhen Liu & Chao Li & Zhiming Shen & Longqi Liu & Chengyu Li & Tao Song & Cirong Liu & Muming Poo & Shiping Liu & Ying Lei & Yidi Sun - 1-24 Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
by Gregory R. Smith & Bingqing Zhao & Malene E. Lindholm & Archana Raja & Mark Viggars & Hanna Pincas & Nicole R. Gay & Yifei Sun & Sindhu Vangeti & Yongchao Ge & Venugopalan D. Nair & James A. Sanford & Mary Anne S. Amper & Mital Vasoya & Kevin S. Smith & Irene Ramos & Stephen B. Montgomery & Elena Zaslavsky & Sue C. Bodine & Karyn A. Esser & Martin J. Walsh & Michael P. Snyder & Stuart C. Sealfon - 1-24 The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
by Typhanie Dumontet & Kaitlin J. Basham & Micah C. Foster & Emma Silverman & Kyle A. Heard & Dominque Johnson & Chaelin Lee & Samuel W. Plaska & David T. Breault & David Penton & Felix Beuschlein & Adina F. Turcu & Christopher R. LaPensee & Antonio Marcondes Lerario & Gary D. Hammer - 1-24 AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape
by Mohammad Sufyan Ansari & Varnit Chauhan & Aashi Singh & Areej Akhtar & Nisha Chaudhary & Reegina Tyagi & Divya & Kashif Husain & Sheetal Sharma & Ruquaiya Alam & Md Shakir & Mehak Pracha & Samreen Anjum & Mohd Nadeem & Prial Taneja & Md Imam Faizan & Iqbal Azmi & Aditya Ramdas Iyer & Pragya Gupta & Mehwish Nafiz & Shayan Ali & Insha Mohi Uddin & Momina Javid & Zahoor Ahmad Bhat & Hamenth Kumar Palani & Amit Kumar Srivastava & Ulaganathan Mabalirajan & Vikram Mathews & Mohammad Husain & Sivaprakash Ramalingam & Gaurav Kharya & Tanveer Ahmad - 1-24 2′-O-methylation-dependent installation of N2-methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly
by Nicole Kleiber & Jonny Petrosyan & Maria Greve & Chairini C. Thomé & Olexandr Dybkov & Laurianne L. E. Tay & Luisa M. Welp & Philipp Hackert & David Touboul & Holger Stark & Markus T. Bohnsack & Henning Urlaub & Lydia Herzel & Marc Graille & Claudia Höbartner & Katherine E. Bohnsack - 1-24 Efficient high-precision transgene knock-in by Recombinases (Redα/β)-enhanced DNA integration-CRISPR-Cas9 (RED-CRISPR)
by Wenqing Li & Senquan Liu & Xiaoyu Fang & Jiaqi Zou & Qin Jiang & Xiaolin Min & Xiaoli Zhu & Yuzhu Cao & Xiaoxiao Gao & Wenjie Han & Muhammad Azhar & Xuemei Xing & Fudong Li & Youming Zhang & Hongbin Liu & Linzhao Cheng & Chengkun Wang & Jianqiang Bao - 1-24 Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice
by Kierra Ware & Joshua Peter & Jake Yazell & Christina Thapa & Aleksandr Taranov & Alicia Bedolla & Claire Distel & Sven Lammich & Regina Feederle & Alice Sülzen & Shane Liddelow & Krishna Roskin & Yu Luo - 1-24 Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification
by Anthony Osuma & Honorine Destain & Jessica Mann & Yinan Li & Seth R. Taylor & Manasa Prahlad & Ian Q. Weigle & Filipe Marques & Natalie Grace Schulz & Laura D. Mathies & Priota Islam & André E. X. Brown & Jayson J. Smith & Paschalis Kratsios - 1-24 Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration
by Qiangqiang Guo & Wei Wang & Xinzhao Jiang & Jincheng Tang & Feng Cai & Wenbo Wang & Lichen Zhang & Ziang Li & Yiyang Huang & Jie Wu & Liang Zhou & Haochen Jiang & Yiwei Zhu & Guhao Cai & Ziyu Lin & Yong Gu & Xuesong Zhu & Liang Chen & Kun Xi - 1-25 Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis
by Haoning Peng & Zhile Wang & Mengyao Wang & Zheyu Ding & Kaixiu Li & Yuqing Wang & Xuejiao Yu & Siyang Song & Yulan Deng & Yi Liu & Qiang Pu & Lu Li & Michael Cerezo & Weiya Wang & Lunxu Liu & Shensi Shen - 1-25 RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
by Junyan Lin & Arantxa Agote-Aran & Yongrong Liao & Mehdi Cloarec & Leonid Andronov & Rafael L. Schoch & Paolo Ronchi & Victor Cochard & Rui Zhu & Erwan Grandgirard & Xiaotian Liu & Marianne Victoria Lemée & Charlotte Kleiss & Christelle Golzio & Marc Ruff & Guillaume Chevreux & Yannick Schwab & Bruno P. Klaholz & Izabela Sumara - 1-25 An in vivo and in vitro spatiotemporal profile of human midbrain development
by Dimitri Budinger & Pau Puigdevall & George T. Hall & Charlotte Roth & Theodoros Xenakis & Elena Marrosu & Julie Jerber & Alessandro Di Domenico & Francesca Picco & Helena Kilpinen & Sergi Castellano & Manju A. Kurian & Serena Barral - 1-25 Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer
by Yapeng Su & Chunmei Liu & Xiang Lu & Hui-Yu Chuang & Guideng Li & Shiqun Shao & Yan Kong & Jihoon W. Lee & Rachel H. Ng & Stephanie Wong & Lidia Robert & Charles Warden & Victoria Liu & Jie Chen & Zhuo Wang & Guangrong Qin & Yin Tang & Hanjun Cheng & Alphonsus H. C. Ng & Daniel Chen & Songming Peng & Min Xue & Dazy Johnson & Yu Xu & Jinhui Wang & Xiwei Wu & Ilya Shmulevich & Qihui Shi & Raphael Levine & Antoni Ribas & David Baltimore & Jun Guo & James R. Heath & Wei Wei - 1-25 Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids
by Carmen Menacho & Satoshi Okawa & Iris Álvarez-Merz & Annika Wittich & Mikel Muñoz-Oreja & Pawel Lisowski & Mario López Martín & Tancredi Massimo Pentimalli & Shiri Zakin & Mathuravani Thevandavakkam & Caleb Jerred & Selene Lickfett & Laura Petersilie & Agnieszka Rybak-Wolf & Annette Seibt & Diran Herebian & Gizem Inak & Susanne Brodesser & Andrea Zaliani & Barbara Mlody & Justin Donnelly & Kasey Woleben & Francesc Xavier Soriano & Jose C. Fernandez-Checa & Natascia Ventura & Sidney Cambridge & Ertan Mayatepek & Antonella Spinazzola & Markus Schuelke & Nikolaus Rajewsky & Andrea Rossi & Alex Peralvarez-Marin & Felix Distelmaier & Ethan Perlstein & Ian J. Holt & Emma Puighermanal & Ole Pless & Christine R. Rose & Antonio Del Sol & Alessandro Prigione - 1-25 Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis
by Masaki Nishioka & Mie Sakashita-Kubota & Kouichirou Iijima & Yukako Hasegawa & Mizuho Ishiwata & Kaito Takase & Ryuya Ichikawa & Naguib Mechawar & Gustavo Turecki & Tadafumi Kato - 1-25 Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging
by Zhen Liang & Jiaqing Xiang & Guangyan Yang & Xiaomai Liu & Lixing Li & Yanchun Li & Yan Lu & Lin Kang & Yuanli Chen & Chuanrui Ma & Shu Yang - 1-25 GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesis
by Hai-Tao Xiao & Peng Song & Jing Jin & Yong-Dan Wang & Yin-Yue Xu & He Wu & Xue-Xue Shao & Qi-Feng Gan & Jian He & Yan-Rong Wen & Jing Zhu & Bao-Yi Chen & Ping Zhou & Li-Na Lai & Hua Yang & Ping Li & Zu-Guo Zheng - 1-25 An intralayer microcircuit in the temporal association cortex underlies sensory-induced escape in mice
by He Li & Jiajia Chen & Wen Zhong & Na Lian & Yumei Huang & Linhui Yao & Peiran Yin & Ziyi Xu & Xiaoxia Qin & Jie Tan & Yingying Zeng & Jinhua Liu & Zhongju Xiao - 1-25 Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis
by Jia-Chen Zheng & Zi-Run Jin & Bo-Heng Liu & Yue Tian & Jia-Xing Li & Jie Cai & Hui Jiang & Guo-Gang Xing - 1-25 CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters
by Fadi Shehadeh & Biswajit Mishra & Raquel Ferrer-Espada & Anindya Basu & LewisOscar Felix & Charilaos Dellis & Narchonai Ganesan & Liyang Zhang & Andrew T. Martens & Youlian Goulev & Michael B. Sherman & Johan Paulsson & Mandar T. Naik & Paul P. Sotiriadis & Eleftherios Mylonakis - 1-25 Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial
by Linda Klümpen & Aakash Mantri & Maren Philipps & Waldemar Seel & Laura Schlautmann & Mohamed H. Yaghmour & Verena Wiemann & Birgit Stoffel-Wagner & Martin Coenen & Leonie Weinhold & Jan Hasenauer & Thomas Fließwasser & Sven Burgdorf & Christoph Thiele & Peter Stehle & Marie-Christine Simon - 1-25 Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar
by Yixuan Yuan & Yujie Xiao & Jie Zou & Liang Luo & Mengyang Li & Kuo Shen & Lai Wei & Yihao Zhang & Peng Wang & Yan Chen & Shixuan Zhuo & Hao Zhang & Shijie Song & Yanhui Jia & Kejia Wang & Shiqing Jiang & Hao Guan & Dahai Hu - 1-26 Phylogenomic profile of exon-intron organization across angiosperms, their relationships with protein domains, and functional implications
by Taikui Zhang & Lin Zhang & Hong Ma & Jun Wang - 1-26 Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues
by Yin Xu & Zurui Huang & Yawei Zhang & Minghui Gong & Zhenghang Wang & Peijin Guo & Feifan Zhang & Jing Yang & Guanghao Liang & Lihui Dong & Renbao Chang & Yu Xia & Haochen Ni & Wenxuan Gong & Boyuan Mei & Yuan Gao & Zhaoqi Liu & Lin Shen & Jian Li & Meng Michelle Xu & Dali Han - 1-26 Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
by Eok-Cheon Kim & Han-Byul Jung & Yu-kyoung Park & Youlim Son & Hye-Na Cha & Yash Patel & Ju Hee Lee & Minah Choi & Soyoung Park & Il-Kug Kim & Lauren Pickel & Seungju Lee & Yuna Ha & Min-Gyeong Shin & Qiwei Zhang & Jielin Yang & Bruno Rodrigues de Oliveira & Nathaniel Vo & Annie Yew & Jacques Togo & Kafi N. Ealey & Su-Ryun Jung & Sunjin Moon & Hye-Jin Yoon & Jee-Young Lee & Hoon-Ki Sung & Jae-Ryong Kim & So-Young Park - 1-26 Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway
by Sun Yi & Huang Wen Xin & Qigang Fan & Xiaoping Yue & Yanbing Lin & Xueyu Chen & Jun Xie & Peize Li & Shuaishuai Xing & Yang Chen & Qiong Lei & Manli Wang & Guo Geng & Zhao De peng & Zhang Hui dong - 1-26 CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
by Linjie Luo & Yan Wang & Tuyen Bui & Xiaoting Jiang & Mei-Kuang Chen & Xiayu Rao & Sepideh Mohammadhosseinpour & Mi Li & Serena Kim & Rachel Y. Kim & Saba Kamaliasl & Carmen W. Ulizio & Spyros Tsavachidis & Juliana Navarro-Yepes & Nicole M. Kettner & Hannah Wingate & Funda Meric-Bernstam & Kelly K. Hunt & Jing Wang & Kerrie Faia & Khandan Keyomarsi - 1-26 Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity
by Yonghua Li & Min Sheng & Weijie Li & Simin Liu & Botao Wang & Bing Liu & Mei Luo & Xiao Zhou & Qiaoxi Xia & Shihong Hong & Ziyuan Zheng & Shi-Yuan Cheng & Xiaobing Jiang & Junjun Li & Tianzhi Huang - 1-26 Pan-RAF inhibitor exarafenib targets BRAF class II/III NSCLC and reveals ARAF-KSR1 resistance and combination strategies
by Tadashi Manabe & Hannah C. Bergo & Qingtian Li & Tim Sen Wang & Paul Severson & Nichol Miller & Catherine Lee & Elifnur Yay Donderici & Nicole Zhang & Wei Wu & Yu-Ting Chou & Daniel L. Kerr & Paul Allegakoen & Kathryn B. Grandinetti & Liliana Soroceanu & Robert J. Pelham & Eric S. Martin & Eric A. Murphy & Vishesh Khanna & Joel W. Neal & Christopher T. Chen & Shumei Kato & Richard Williams & Trever G. Bivona - 1-26 Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes
by Jianing Li & Anthony F. Tanzillo & Giusy Pizzirusso & Adam Caccavano & Ramesh Chittajallu & Mira Sohn & Daniel Abebe & Yajun Zhang & Kenneth A. Pelkey & Ryan K. Dale & Chris J. McBain & Timothy J. Petros - 1-26 Discovery of NIRF theranostic probes targeting amyloid-β and cholinesterases in Alzheimer’s disease models
by Himanshu Rai & Rishabh Singh & Gauri Shankar & Sanskriti Rai & Prabhat Kumar & Aishwarya S. Nilakhe & Neha Singh & Poonam Bhadoria & Gourav Singh & Venkatnarayan Ramanathan & Sarika Gupta & Sairam Krishnamurthy & Saripella Srikrishna & Saroj Kumar & Gyan Modi - 1-26 Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design
by Linling He & Yi-Zong Lee & Yi-Nan Zhang & Maddy L. Newby & Benjamin M. Janus & Fabrizio G. Gonzalez & Garrett Ward & Connor DesRoberts & Shr-Hau Hung & Erick Giang & Joel D. Allen & Liudmila Kulakova & Eric A. Toth & Thomas R. Fuerst & Mansun Law & Gilad Ofek & Max Crispin & Jiang Zhu - 1-26 A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities
by Zhenyu Yang & Shiyou Wei & Hao Duan & Xiuqi Wang & Dainan Zhang & Karrie Mei-Yee Kiang & Yulan Deng & Yuanzhong Yang & Yin Ku & Wanming Hu & Chaowei Zou & Meiqin Tang & Yu Jiang & Yu Liu & Hongbin Lan & Zexin Chen & Gilberto Ka-Kit Leung & Wang Jia & Yonggao Mou & Lunxu Liu & Gao Zhang - 1-27 Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
by Cathy C. Garcia & Aarthi Venkat & Daniel C. McQuaid & Sherry S. Agabiti & Alexander Tong & Boby Mathew & Rebecca L. Cardone & Rebecca Starble & Christian F. Ruiz & Christy Zheng & Akin Sogunro & Jeremy B. Jacox & Ken H. Loh & Richard G. Kibbey & Smita Krishnaswamy & Mandar Deepak Muzumdar - 1-27 Printing technologies for monitoring crop health
by David Panáček & Vojtěch Kupka & Martin-Alex Nalepa & Ivan Dědek & Ruslan Álvarez-Diduk & Selin Olenik & Jose Flauzino & Jan Zdražil & Petr Jakubec & Lukáš Zdražil & Lukáš Spíchal & Keval K. Sonigara & Radek Zbořil & Martin Pumera & Arben Merkoçi & Joseph Wang & Nuria De Diego & Firat Güder & Michal Otyepka - 1-27 Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model
by Zhihua Ou & Zhaoyang Wang & Qi Chen & Peidi Ren & Xiuju He & Yan Liang & Ying’an Liang & Jiaxuan Wang & Sha Liao & Dexin Wang & Jie Zhao & Oujia Zhang & Zhenyu Peng & Jianxin Su & Wangsheng Li & Guohai Hu & Ao Chen & Ziqing Deng & Xin Jin & Xun Xu & Junhua Li & Gong Cheng - 1-27 Escherichia coli promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps
by Banglun Pan & Yuxin Yao & Zhu Zhang & Dongjie Ye & Hao Wu & Xinyu Zhang & Xiaoqian Wang & Nanhong Tang - 1-27 Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum
by Cecilia P. Sanchez & Maëlle Duffey & Romina V. Celada & Michal Kucharski & Marie Hoarau & Thanaya Saeyang & Sumalee Kamchonwongpaisan & Farzin Sohraby & Svenja de Buhr & Ariane Nunes Alves & Amuza Byaruhanga Lucky & Jun Miao & Clement Regnault & Jerzy M. Dziekan & Zbynek Bozdech & Michael P. Barrett & Michael Lanzer - 1-27 Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure
by Manju Kumari & Ioannis Evangelakos & Anushka Deshpande & Kirstie A. De Jong & Nesrin Schmiedel & Nicolàs Palacio-Escat & Adriano de Britto Chaves-Filho & Roberto Carlos Frias-Soler & Glynis Klinke & Hyun Cheol Roh & Luisa Lange & Michael Berlin & Marceline M. Fuh & Jakob Johannes Buss & Tian Tian & Carolin Lerchenmüller & Marc Freichel & Almut Schulze & Viacheslav O. Nikolaev & Thomas Eschenhagen & Evan D. Rosen & Ludger Scheja & Ashraf Yusuf Rangrez & Joerg Heeren & Norbert Frey - 1-27 Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis
by Qirui Zhao & Tongtong Xu & Zuchao Du & Xiaoqing Lu & Yan Zhang & Linjia Peng & Zixuan Gao & Weicheng Wang & Binyu Zhu & Zhigang Liu & Guangjie Yang & Hui Zhao & Zhiming Song & Qiankun Lou & Jiaming Li & Zhiguang Ren & Zhe Yu & Wei Wang & Yanlei Liu & Hui Liang & Jesus M. de la Fuente & Daxiang Cui - 1-27 Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice
by Cristina Cuesta-Marti & Eduardo Ponce-España & Friederike Uhlig & Iris Stoltenborg & Luiza A. Wasiewska & Lamiah Kareem & Dara Hedayatpour & Loreto Olavarría-Ramírez & Cristina Rosell-Cardona & Thomaz. F. S. Bastiaanssen & Gabriel. S. S. Tofani & Benjamin Valderrama & Klara Vlckova & Suzanne L. Dickson & Aonghus Lavelle & Catherine Stanton & R. Paul Ross & John F. Cryan & Timothy G. Dinan & Gerard Clarke & Siobhain M. O’Mahony & Harriët Schellekens - 1-27 A multifaceted model of Entamoeba histolytica KERP2 regulating gene expression and host cell responses
by Ruofan Peng & Herbert J. Santos & Tomoyoshi Nozaki - 1-27 Reprogramming of bacterial virulence by lysine acetylation
by Ole Schmöker & Britta Girbardt & Sabrina Schulze & Gottfried J. Palm & Leona Berndt & Jens Hoppen & Nilüfer Kara & Xenia Schöps & Ruba Al-Abdulla & Klara Garz & Heike Junker & Sophie Wolfgramm & Leif Steil & Christian Hentschker & Katrin Schoknecht & Lea-Maria Mayer & Leonie Speth & Vanessa Lachmayer & Mark Dörr & Stefan Kemnitz & Stefan Müller & Jan-Wilm Lackmann & Marcus Krüger & Kay Hofmann & Uwe T. Bornscheuer & Uwe Völker & Elke Krüger & Vera Kozjak-Pavlovic & Michael Lammers - 1-28 Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection
by Haoyi Chen & Li Wei & Qiang Yu & Chenxi Wang & Huizhen Fan & Ming Li & Ruonan Dong & Yingying Ma & Jiahao Jiang & Lianfu Deng & Mei X. Wu & Min Lu - 1-28 The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex prediction
by Adriano Setti & Giorgio Bini & Flaminia Pellegrini & Valentino Maiorca & Gabriele Proietti & Dimitrios-Miltiadis Vrachnos & Angelo D’Angelo & Alexandros Armaos & Julie Martone & Michele Monti & Giancarlo Ruocco & Emanuele Rodolà & Irene Bozzoni & Alessio Colantoni & Gian Gaetano Tartaglia - 1-28 Segmented filamentous bacteria are worldwide human gut commensals
by Shashi Kiran & Ana Raquel Cruz & Alice Daniau & Bing Ma & Martial Marbouty & Juliana Pipoli Da Fonseca & Agnès Legrand & Lyam Baudry & Thomas Cokelaer & Matthieu Bensussan & Maryse Moya-Nilges & Julian Garneau & Marc Monot & John B. Ochieng & Martin Antonio & Boubou Tamboura & Willem M. de Vos & Anne Salonen & Jahangir Hossain & Richard Omore & Samba O. Sow & Philippe J. Sansonetti & Jacques Ravel & Nadine Cerf-Bensussan & Pamela Schnupf - 1-28 Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage
by Irina Poverennaya & Aliia Murtazina & Lei Li & Lorena Maili & Lukas Sourada & Luis Fernando Montano-Gutierrez & Rozalina Galimullina & Tobias Steinschaden & Marketa Kaiser & Tomas Zikmund & Adna Goralija & Teng Gao & Aurore Attina & Ornella Clara & Christoph Bartenhagen & Alek Erickson & Yaakov Gershtein & Shiyuan Chen & Kristyna Polaskova & Jaroslav Sterba & Bettina Semasch & Emma R. Anderson & Varsha Prakash & Theresa Vincent & Maria Arceo & Per Kogner & Susanne Schlisio & Peter V. Kharchenko & Alexandre David & Jozef Kaiser & Matthias Fischer & Jan Skoda & Paul A. Trainor & Andrei S. Chagin & Igor Adameyko - 1-30 Robust characterization and interpretation of rare pathogenic cell populations from spatial omics using GARDEN
by Xinming Zhang & Zhuohan Yu & Gaoyang Hao & Qi Yao & Yanmei Hu & Fuzhou Wang & Xingjian Chen & Linjing Liu & Ka-Chun Wong & Xiangtao Li - 1-30 Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering
by Jie Li & Zishuo Wang & Wenjing Yang & Yuchen Zhang & Yanjun Wang & Xuhui Wang & Hongrui Wang & Yang Xie & Shuogui Xu & Yan Shang & Chunyu Xue & Yuntong Zhang & Shuo Fang - 1-30 Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol
by Jing Lan & Jiaqi Wang & Sijuan Huang & Chenyu Li & Ziteng Deng & Zhihui Hao & Yunfei Ma - 1-30 Developments and challenges in hit progression within fragment-based drug discovery
by Harold Grosjean & Philip C. Biggin - 1-32 NEDAMSS syndrome-related truncating and missense mutations are associated with aberrant liquid-liquid phase separation of IRF2BPL
by Marco Dell’Oca & Stefania Boggio Bozzo & Serena Vaglietti & Chiara Marchetti & Chiara Di Luca & Pietro Munarin & Michael Nicoli & Rossella Indellicato & Davide Ravanelli & Giorgia Falanga & Angelo Iannielli & Mirko Luoni & Alessia Loffreda & Valeria Berno & Paolo Bianchini & Sarah Sertic & Antonio Conforti & Shima Rashidiani & Eleonora Aimaretti & Massimo Collino & Ilaria Cecere & Angelo Gallo & Federica Santoro & Diego Brancaccio & Samuele Rosso & Giovanna Di Nardo & Raffaele Pertusio & Federico Cesano & Francisco J. Monje Quiroga & Mirella Ghirardi & Silvestro Roatta & Luca Colnaghi & Ferdinando Fiumara