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Content
December 2026, Volume 17, Issue 1
- 1-22 A physics-informed graph neural network conserving linear and angular momentum for dynamical systems
by Vinay Sharma & Olga Fink
- 1-22 Whole body regeneration deploys a rewired embryonic gene regulatory network logic
by Rita Andreoni-Pham & Hereroa Johnston & Jacob F. Warner & Karine Nedoncelle & João E. Carvalho & Kai Hofmänner & Agata Maugeri & Olivier Croce & Aldine R. Amiel & Eric Röttinger
- 1-22 Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation
by Xianfa Yang & Bingbing Xie & Penglei Shen & Yingying Chen & Chunjie Li & Fengxiang Tan & Yumeng Yang & Yun Yang & Rui Song & Panpan Mi & Zhiwen Liu & Mingzhu Wen & Patrick P. L. Tam & Shengbao Suo & Naihe Jing
- 1-22 Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity
by Louise Gorline & Fillipe Luiz Rosa do Carmo & Pierre Bourdely & Jérémie Bornères & Nathan Vaudiau & Aurélie Semervil & Mathias Vetillard & Aboubacar Sidiki K Coulibaly & Natacha Jugniot & Agathe Ok & Mathilde Bausart & Oriane Fiquet & Marine Andrade & Dicken Fardol & Ikrame Haddar & Zeina Abou Nader & Judith Weber & Hannah Theobald & Matthieu Collin & Joseph Calmette & Giorgio Anselmi & Flavia Fico & Florent Ginhoux & Laleh Majlessi & Emmanuel L. Gautier & Loredana Saveanu & Julie Helft & Marc Dalod & Mathilde Dusseaux & James P. Di Santo & Stéphanie Hugues & Pierre Guermonprez
- 1-22 TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
by Astrid F. Feiten & Kilian Dahm & Kai Schlepckow & Bettina van Lengerich & Jung H. Suh & Anika Reifschneider & Benedikt Wefers & Laura M. Bartos & Karin Wind-Mark & Lis de Weerd & Thomas Ulas & Elena De-Domenico & Pia Grundschöttel & Stefan Paulusch & Benjamin Tast & Tamisa Honda & Stephan A. Müller & Matthias Becker & Igor Khalin & Alessio Ricci & Arthur Liesz & Bettina Brunner & Claudia Krenner & Katrin Buschmann & Brigitte Nuscher & Lena Spieth & Niklas Junker & Stefan A. Berghoff & Sonnet S. Davis & Jonas J. Neher & Wolfgang Wurst & Nikolaus Plesnila & Joseph W. Lewcock & Mikael Simons & Stefan F. Lichtenthaler & Gilbert Di Paolo & Matthias Brendel & Anja Capell & Kathryn M. Monroe & Joachim L. Schultze & Christian Haass
- 1-22 Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs
by Shengfei Huang & Meng Li & Huiru Xu & Tianyu Shu & Honglin Jia & Zhenlong Li & Yutong Yang & Xin Zhao & Baolin Guo
- 1-22 NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice
by Tabea M. Hein & Ester Nespoli & Marsela Hakani & Heinrich Wendt & Stephanie Nadine May & Jasmin Jorzik & Duygu Yagdiran & Judith S. Schlett & Konstantinos Tsesmelis & Miltiadis Tsesmelis & Vivien Prex & Melanie Mettang & Alireza Abaei & Volker Rasche & Michael Lattke & Franz Oswald & Markus Huber-Lang & Leda Dimou & Thomas Wirth & Bernd Baumann
- 1-22 Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice
by Veronica Bergo & Pavlos Bousounis & Giang To Vu & Mélodie Douté & Aikaterini Polyzou & Maria-Eleni Lalioti & Bogdan B. Grigorash & Lyudmila Tsurkan & Nicholas Morchel & Ward Deboutte & Frédéric Brau & Thomas Manke & Sagar & Hind Medyouf & Dmitry V. Bulavin & Nina Cabezas-Wallscheid & Marta Derecka & Eirini Trompouki
- 1-22 Slower-growing species promote interspecific cooperation and coexistence under acid stress through cross-feeding
by Hui Liao & Liming Wu & Yi Luo & Hussain Asif & Xinlei Huang & Xiaole Xia
- 1-22 MYC drives left-handed Z-DNA formation to shape gene expression
by Xinyi Wan & Haonan Fan & Zhuoning Li & Yixuan Du & Yu Liu & Weiwu Zeng & Zhongxing Sun & Juejia Shao & Junqi Jia & Yanjun Zhang & Dong Fang
- 1-22 The functional landscape of alternative splicing in hematopoietic lineage commitment
by Xiao Hu & Jinrui Wang & Li Chen & Qin Yang & Manuel Tardaguila & Bin Mao & Shenghui Niu & Zijie Xu & GuiHua Wang & Dan Zhang & Yating Zhang & Zhen Zhou & Jing Luo & Zhifeng He & Defu Liu & Chao Tang & Nicole Soranzo & Jing-wen Lin & Da Jia & Lu Chen
- 1-22 A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses
by Abigail E. Powell & Hannah Caruso & Soyoon Park & Jui-Lin Chen & Jessica O’Rear & Brian J. Ferrer & Daniel J. Stieh & Adam M. Weiss & David M. Belnap & Audrey Walker & Anneliese Bruening & Airn Hartwig & Kaitlin R. Sprouse & Amin Addetia & Abeer N. Alshukairi & Vida Ahyong & Cristy S. Dougherty & David Veesler & Richard Bowen & Julie E. Ledgerwood & Michael S. Kay & Payton A.-B. Weidenbacher & Brad A. Palanski
- 1-22 KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis
by Xiao-Yu He & Cheng-Yan Liu & Xin-Yu Ding & Qing Lin & Jia-Fu Leng & Cheng-Mei Xiao & Xin Zang & Meng-Yue Wang & Yong Yin & Ling-Yi Kong & Yuan-Zheng Xia
- 1-22 A pooled Cell Painting CRISPR screening platform enables de novo inference of gene function by self-supervised deep learning
by Srinivasan Sivanandan & Bobby Leitmann & Eric Lubeck & Mohammad Muneeb Sultan & Panagiotis Stanitsas & Navpreet Ranu & Alexis Ewer & Jordan E. Mancuso & Zachary F. Phillips & Albert Kim & John W. Bisognano & John Cesarek & Fiorella Ruggiu & David Feldman & Daphne Koller & Eilon Sharon & Ajamete Kaykas & Max R. Salick & Ci Chu
- 1-22 Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature
by Yameng Wang & Zhiwen Wu & Jinghong Yuan & Junchao Zhu & Marco Ventin & Shahrzad Arya & Peng Yu & Giulia Cattaneo & Guowen Huang & Wenrui Zhao & Shengqin Li & Junqiu Zhang & Qi Chen & Xinhui Wang & Lianyong Li & Xijuan Liu & Xigao Cheng & Jingyu Jia
- 1-22 Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex
by Wolfgang P. Ruf & Julia K. Kühlwein & Laura Meier & Sarah J. Brockmann & Jaehyun LeeBae & Ghazaleh Sadri-Vakili & Deniz Yilmazer-Hanke & Susanne Petri & Dietmar R. Thal & Veselin Grozdanov & Karin M. Danzer
- 1-22 Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation
by Tim Vervliet & Jens Loncke & Marko Sever & Karan Ahuja & Chris Van den Haute & Tomas Luyten & Grace E. Stutzmann & Catherine Verfaillie & Tihomir Tomašič & Geert Bultynck
- 1-22 De novo design of epitope-specific antibodies via a structure-driven computational workflow
by Fandi Wu & Yu Zhao & JiaXiang Wu & Biaobin Jiang & Bing He & Longkai Huang & Chenchen Qin & Yang Xiao & Fan Yang & Rubo Wang & Ningqiao Huang & Huaxian Jia & Yuyi Liu & Houtim Lai & Tingyang Xu & Fang Wang & Zihan Wu & Yidong Song & Shaoning Li & Wei Liu & Yu Rong & Peilin Zhao & Jianhua Yao
- 1-22 Volatile and non-volatile pathogen cues shape host extracellular vesicles production in pre-infection response
by Klaudia Kołodziejska & Agata Szczepańska & Satya Vadlamani & Ramakrishnan Ponath Sukumaran & Mariusz Radkiewicz & Henrik Bringmann & Nathalie Pujol & Wojciech Pokrzywa & Michał Turek
- 1-22 SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability
by Alessandro Ferrando & Michele Giaquinto & Luisa M. R. Napolitano & Giulia Canarutto & Alessandro Framarini & Alice Gambelli & Pamela Veneziano Broccia & Annie Zappone & Eleonora Petti & Chiara Boncristiani & Andrea Parlante & Silvia Onesti & Silvano Piazza & Roberta Benetti & Stefan Schoeftner
- 1-22 Advances and challenges in non-canonical nucleic acids data storage
by Yan Wang & Yufeng Pei & Linlin Tang & Xinyu Sun & Songtao Zhou & Jie Song
- 1-22 The inflammatory path toward type 1 diabetes begins during pregnancy
by Angelica P. Ahrens & Raquel Dias & Tuulia Hyötyläinen & Matej Orešič & Eric W. Triplett & Johnny Ludvigsson
- 1-22 Computational and neural mechanisms underlying the influence of action affordances on value learning
by Sanghyun Yi & John P. O’Doherty
- 1-22 A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis
by Wenjing Yan & Daniel C. Talley & Antara Syam & Carina Danchik & Yongwang Zhong & Xianzheng Zhang & Xiaoying Liu & Bolormaa Baljinnyam & Stephen C. Kales & Matthew G. Cyr & Yuhong Fang & Alexey V. Zakharov & Xin Hu & Taylor Niehoff & Tuan Xu & Yanyan Qu & Allison Yang & Valentine V. Courouble & Qin Yao & Anton Simeonov & Ruili Huang & Tatiana K. Rostovtseva & Sergey M. Bezrukov & Christopher A. LeClair & Josephine M. Egan & Hua Wang & Dingyin Tao & Ganesha Rai & Mark J. Henderson & Shengyun Fang
- 1-22 Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids
by M. Bertin & H. Todorov & S. Frank & S. Käseberg & R. Menon & E. Gabassi & C. Foerster & N. Bobon & F. Furlanetto & A. Soliman & H. M. B. Ibrahim & V. Engelhardt & L. Birschmann & H. Brennenstuhl & B. Lohrer & A. Mas-Sanchez & E. Cesare & J. Winter & J. Krummeich & J. Winkler & B. Winner & E. Weis & S. Diederich & K. Luck & P. Lunt & S. Gerber & P. Baumann & N. Elvassore & B. Berninger & MF Basilicata & S. Schweiger & S. Falk & M. Karow
- 1-22 Reconstruction of the lifeways of Central European Late Bronze Age communities using ancient DNA, isotope and osteoarchaeological analyses
by Eleftheria Orfanou & Ayshin Ghalichi & Adam B. Rohrlach & Enrico Paust & Aida Andrades Valtueña & Michal Ernée & Mirosław Furmanek & Agata Hałuszko & Taylor Hermes & Marie Himmel & Jana Ilgner & Johannes Krause & Mario Küßner & Thiseas Christos Lamnidis & Mary Lucas & Drahomíra Adámková Malyková & Harald Meller & Gunnar U. Neumann & Luka Papac & Sandra Penske & Maike Salinger & Sarah A. Schrader & Torsten Schunke & Lena Semerau & Lubor Smejtek & Luca Traverso & Barbara Zach & Robert Spengler & Philipp W. Stockhammer & Joachim Wahl & Christophe Snoeck & Peter Ettel & Florian N. Schneider & Patrick Roberts & Wolfgang Haak
- 1-22 FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication
by Nibal Badra-Fajardo & Elena Karydi & Aleix Bayona-Feliu & Belén Gómez-González & Ourania Preza & Marina Arbi & Argyro Kalogeropoulou & Juha K. Rantala & Stavros Taraviras & Andrés Aguilera & Zoi Lygerou
- 1-22 Analysis of the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins using snFLARE-seq and mxFRIZNGRND
by Dongyin He & Haoran Hu & Kai Xiao & Yuhang Zhang & Yongbing Cheng & Shaozhuo Jiao & Yimei Hao & Yuanyuan Cai & Ziqun Liu & Xinran Yan & Qinsheng Chen & Xiyan Mu & Qi Wang & Shan Peng & Guoqin Sang & Xiaoling Zhi & Yanxia Chang & Qing Ye & Yuyao Yang & Meixia Che & Shengsong Huang & Hongqian Guo & Luonan Chen & Huiru Tang & Xuefeng Qiu & Zhenfei Li
- 1-22 1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis
by Wenfeng Liao & Dianxiu Cao & Ying Wang & Zhenyun Du & Jian Yao & Pengfei Dou & Yuandong Zheng & Zhiming Wang & Xia Chen & Peipei Wang & Chungwah Ma & Hao Chen & Xingxing Diao & Kaiping Wang & Kan Ding
- 1-22 Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis
by Bing Liu & Min Liu & Yajuan Zhang & Yifei Zhu & Dingpei Zhou & Hong Gao & Fan Yang & Dong Gao & Yun Zhao & BangBao Tao & Feng Yao & Weiwei Yang
- 1-22 Electrostatic properties of disordered regions control transcription factor search and pioneer activity
by Sim Sakong & Beat Fierz & David M. Suter
- 1-22 Robotic leaping enhanced by thrust-induced hypogravity, achieving precise, predictable, and extended jumps
by Zijie Sun & Jianguo Zhao & Yangmin Li & Long Teng
- 1-22 A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice
by Sara S. Kornfeld-Sylla & Cigdem Gelegen & Jordan E. Norris & Francesca A. Chaloner & Maia Lee & Michael Khela & Maxwell J. Heinrich & Peter S. B. Finnie & Lauren E. Ethridge & Craig A. Erickson & Lauren M. Schmitt & Sam F. Cooke & Carol L. Wilkinson & Mark F. Bear
- 1-22 Natural photosynthetic system for restoring homeostasis of animal organelle interaction network
by Chen Xia & Zhanqiu Dai & Yongcheng Wang & Jiachen Yu & Zijie Wang & Zhenxiang Huang & Kaifeng Pan & Ke Yang & Yiyu Chen & Peiyu Zhong & Chenhui Gu & Shunwu Fan & Xianfeng Lin & Pengfei Chen
- 1-22 Identification of a lipid oxygen radical defense pathway and its epigenetic control
by Francisco S. Mesquita & Laurence Abrami & Romain Forey & Béatrice Kunz & Charlène Raclot & Lucie Bracq & Filipe Martins & Danica Milovanovic & Evarist Planet & Olga Rosspopoff & Didier Trono & F. Gisou van der Goot
- 1-22 Silencing lipid catabolism determines longevity in response to fasting
by Lexus Tatge & Juhee Kim & Rene Solano Fonseca & Kyle Feola & Jordan M. Wall & Gupse Otuzoglu & Ann C. Johnson & Kielen R. Zuurbier & Jaeyoung Oh & Shaghayegh T. Beheshti & Victor A. Lopez & Anthony J. Daley & Emma G. Werner & Patrick Metang & Sonja L. B. Arneaud & Abigail Watterson & Jeffrey G. McDonald & Vincent S. Tagliabracci & Michael E. French & Peter M. Douglas
- 1-22 Robust minimally-invasive microfabricated stainless steel neural interfaces for high resolution recording
by Zabir Ahmed & Ibrahim Kimukin & Vishal Jain & Kate Gurnsey & Tobias Teichert & Maysamreza Chamanzar
- 1-22 Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths
by Ryan J. McGinty & Daniel J. Balick & Sergei M. Mirkin & Shamil R. Sunyaev
- 1-22 Hypoxia-driven remodeling of SELENOP+ macrophages shapes T cell dynamics and promotes ovarian cancer metastasis
by Qing Liu & Chenzhao Feng & Tianhao Wu & Siyang Zhang & Xinyi Wang & Qian Zhao & Xueying Song & Shuangyan Liu & Linru Quan & Yuli Zhang & Shimin Zhang & Bin Yang & Jixin Li & Gang Chen & Xuanzhang Huang & Chaoyang Sun & Xin Zhou
- 1-22 Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma
by Hongli Zhang & Zixuan Wang & Yiqi Zhao & Xiya Deng & Jian Zhang & Fei Shang & Hongjie Zhang & Yan Liu & Hongbo Wang & Yating Yang & Huiyu Lin & Bo Zhang & Ce Liu & Fan Guo & Ruolin Zhang & Qipeng Yuan & Yue Feng & Shi-Zhong Luo & Wei-Dong Chen & Yan-Dong Wang
- 1-22 ARMH4 accelerates aging by maintaining a positive-feedback growth signaling circuit
by Yu Fang & Baosen Wang & Qiuxiao Guo & Jian Lv & Jiajie Li & Junmei Wang & Ningning Guo & Yu Bai & Anqi Xu & Xiao Ma & Hui Tan & Hong Li & Zhihua Wang
- 1-22 Uncovering the molecular logic of cortical wiring between neuronal subtypes across development through ligand–receptor inference
by Rémi Mathieu & Tangra Draia-Nicolau & Léa Corbières & Annousha Govindan & Vianney Bensa & Emilie Pallesi-Pocachard & Lucas Silvagnoli & Alfonso Represa & Carlos Cardoso & Ludovic Telley & Antoine de Chevigny
- 1-22 A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches
by Pranali Sonpatki & Hyun Jung Park & Yao Lulu Xing & Kyung Yeon Han & Brett A. Schroeder & Hyeon Jong Yu & Hye Jin Kim & Tamrin Chowdhury & Jong Ha Hwang & Sun Mo Nam & Yoon Hwan Byun & Ho Kang & Joo Ho Lee & Soon-Tae Lee & Jae-Kyung Won & Tae Min Kim & Seung Hong Choi & Ja-Lok Ku & Sungyoung Lee & Hongseok Yun & Sung-Hye Park & Claudia K. Petritsch & Chul-Kee Park & Woong-Yang Park & Nameeta Shah
- 1-22 Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques
by K. Marche & N. Trudel & U. Schüffelgen & S. Smart & C. M. Harbison & J. Scholl & J. Sallet & F-X Neubert & J. Algermissen & N. Khalighinejad & JX O’Reilly & MC Klein-Flügge & MFS Rushworth
- 1-22 Rochelle salt-based biodegradable piezoelectric devices for nerve regeneration and intestinal motility monitoring
by Fanqi Dai & Haofeng Cheng & Hui Qi & Honglai Cai & Abdul Aziz & Tianqi Su & Yanjun Guan & Yuhui Cui & Jingwei Meng & Handi Deng & Qianxi Wu & Yongsheng Jie & Lei Chen & Sixu Wang & Tianyi Feng & Wei Li & Fei You & Shengnan Liu & Bingbing Yu & Can Yang & Jiang Peng & Xing Sheng & Jing-feng Li & Milin Zhang & Qian Li & Cheng Ma & Lei Tian & Jun Zhang & Yu Wang & Lan Yin
- 1-22 Targeting TNK2/ACK1 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer
by Chao Wu & Weishuai Liu & Xiangting Hu & Yongjie Xie & Shengnan Li & Xinyue Liu & Zhaojun Sun & Xiaoling Li & Xin Yu & Yudong Yuan & Yiping Zou & Ran An & Yanan Chen & Hailong Wang & Yukuan Feng & Song Gao & Hongwei Wang & Yifei Wang & Nan Wang & Chao Yang & Jun Yu & Peiqing Sun & Chongbiao Huang & Antao Chang & Jihui Hao
- 1-22 Residual tumor cells after insufficient radiofrequency ablation promote lung metastasis by educating CD177hiPAD4hi neutrophils
by Na Huang & Yisheng Fang & Siting Zheng & Jianhua Wu & Genjie Huang & Xinyue Deng & Yijin Guan & Bishan Liang & Dongqiang Zeng & Beibei Xu & Yuanwen Huang & Xiaoxiang Rong & Chunlin Wang & Jianping Bin & Yulin Liao & Zuqiang Wu & Min Shi & Wangjun Liao
- 1-22 VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement
by Somya Vats & Pedro Dionisio & Quentin Lemercier & Raphael Pineau & Ludivine Therreau & Joanna Lipecka & Béatrice Cholley & Jean-Baptiste Moog & Jose Wojnacki & Céline Keime & Diana Zala & Philippe Bun & Sofia Freire & Neuza Domingues & Lydia Danglot & Ida Chiara Guerrera & Cédric Delevoye & Eric Chevet & Nuno Raimundo & Thierry Galli
- 1-22 A quantitative, multimodal wearable bioelectronic device for comprehensive stress assessment and sub-classification
by Xiaochang Pei & Anita Ghandehari & Shingirirai Chakoma & Jerome Rajendran & Jorge Alfonso Tavares-Negrete & Rahim Esfandyarpour
- 1-22 Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion
by Qinfu Chen & Xueying Yuan & Miao Shi & Xinyu Zhou & Shukai Zhu & Weiguo Lu & Haiyan Yan & Fangwei Wang
- 1-22 Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy
by Yue Yin & Zixuan Li & Weijie Shu & Hening Liu & Zihan Wang & Cong Fu & Yuanbo Zhu & Xuejing Li & Yi Zhang & Bei Lv & Zixuan Wang & Qiaoqiao Zhao & Dan Liu & Lu Tang & Wei Wang
- 1-22 Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation
by Lirong Zhai & Yuan Cheng & Meixuan Wu & Tianzhuo Wang & Meichen Yin & Xiao Yang & Bowen Sun & Chengcheng Li & Miao He & Yi Sun & Yiqian Zhao & Yuqi Xing & Bo Liu & Ling Zhou & Yuanyuan Liu & Miao Yu & Yijiao He & Hongquan Zhang & Jun Zhan & Jianliu Wang
- 1-22 Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking
by Caroline G. Spencer & Matthew Hamilton & Ethan Bedsole & Yingshan N. Wei & Alison M. Rojas & Andrew Burciu & John Zhu & Keith Z. Sabin & Celia E. Shiau
- 1-22 Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male
by Xuan Wan & Tingtao Zhou & Vladislav Susoy & Alessandro Groaz & Core Francisco Park & John F. Brady & Aravinthan D. T. Samuel & Paul W. Sternberg
- 1-22 Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo
by Zunyong Feng & Liuxi Chu & Qiang Li & Jing Zhou & Ping Wu & Xuanbo Zhang & Yuanbo Pan & Jianhua Zou & Qun Chen & Zhiliang Xu & Liang Yan & Yanjiao Huang & Xiaokun Li & Zhouguang Wang & Xiaoyuan Chen
- 1-22 TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation
by Bruno Ghirotto & Luís Eduardo Gonçalves & Vivien Ruder & Christina James & Elizaveta Gerasimova & Tania Rizo & Holger Wend & Michaela Farrell & Juan Atilio Gerez & Natalia Cecilia Prymaczok & Merel Kuijs & Maiia Shulman & Anne Hartebrodt & Iryna Prots & Arne Gessner & Michael Vieth & Friederike Zunke & Jürgen Winkler & David B. Blumenthal & Fabian J. Theis & Roland Riek & Claudia Günther & Markus Neurath & Pooja Gupta & Beate Winner
- 1-22 Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs
by Mingqi Hou & Wenjun Zhang & Ziping Qi & Guiming Li & Husheng Mei & Shuang Qi & Rui Jin & Yuedong Zhao & Xiaochen Tang & Bing Xiu & Xiaotong Chen & Yunshuo Zhao & Chen Hu & Changlin Qian & Xiuchun Li & Zhan Xu & Yongfei Chen & Chao Wu & Beilei Wang & Lejin Yan & Dan Li & Yushan Huang & Rui Liang & Aoli Wang & Jing Liu & Wenchao Wang & Bin Li & Jun Long & Ping Li & Aibin Liang & Qingsong Liu & Jing Yang
- 1-23 Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
by Sabrina Pia Nuccio & Enrico Cadoni & Roxani Nikoloudaki & Silvia Galli & An-Jie Ler & Claudia Sanchez-Cabanillas & Thomas E. Maher & Ella Fan & Dilek Guneri & Gem Flint & Minghui Zhu & Ling Sum Liu & Christopher R. Fullenkamp & Zoë Waller & Luca Magnani & John S. Schneekloth Jr & Marco Di Antonio
- 1-23 Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration
by Shasha Li & Hui Liu & Shao-Hui Pan & Zhengbiao Zhu & Shun Zhang & Jiahang Li & Yinghao Yao & Xinyu Wang & Na Gao & Xiaoyu Liu & Ming Chen & Huijuan Hu & Wenmin Pan & Qunyan Zhu & Yaoyao Cai & Jia Qu & Shaorong Gao & Jianzhong Su
- 1-23 Comprehensive discovery of m6A sites in the human transcriptome at single-molecule resolution
by Gihyeon Kang & Hyeonseo Hwang & Hyeonseong Jeon & Heejin Choi & Hee Ryung Chang & Nagyeong Yeo & Junehee Park & Narae Son & Eunkyeong Jeon & Jungmin Lim & Jaeung Yun & Wook Choi & Jae-Yoon Jo & Jong-Seo Kim & Sangho Park & Yoon Ki Kim & Daehyun Baek
- 1-23 Molecular signatures of resilience to Alzheimer’s disease in neocortical layer 4 neurons
by S. Akila Parvathy Dharshini & Jorge Sanz-Ros & Jie Pan & Weijing Tang & Kristen Vallejo & Yu Chen Liu & Marcos Otero-Garcia & Inma Cobos
- 1-23 Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC
by Subhamoy Chakraborty & Andrew Elliott & Utsav Sen & Charles Coleman & Vrinda Jethalia & Kedwin Ventura & Chih-Wei Fan & Ramja Sritharan & Avisek Banerjee & Yazhini Mahendravarman & Ari Vanderwalde & Balazs Halmos & Elisa de Stanchina & Hirokazu Taniguchi & Deniz Demircioglu & Dan Hasson & Triparna Sen
- 1-23 Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks
by Paris Mazzachi & Ella McDonald & Zarina Greenberg & Alejandra Noreña Puerta & Jenne Tran & Manam Inushi De Silva & Cade Christensen & Robert Adams & Sebastian Loskarn & Helen Beard & Michael Zabolocki & Meera Elmasri & Megan Maack & Kristina L. Elvidge & Mark R. Hutchinson & Cara O’Neill & Kim M. Hemsley & Lisa Melton & Nicholas Smith & Cedric Bardy
- 1-23 Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State
by Yusuke Tsutsui & Atsushi Masui & Satoshi Konishi & Taro Tsujimura & Mio Iwasaki & Takuya Yamamoto & Shimpei Gotoh
- 1-23 Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation
by Hok Ning Tsui & Charmaine Yan Yu Wong & Chaogu Zheng & Karen Wing Yee Yuen
- 1-23 Backpropagation through space, time and the brain
by Benjamin Ellenberger & Paul Haider & Federico Benitez & Jakob Jordan & Kevin Max & Ismael Jaras & Laura Kriener & Mihai A. Petrovici
- 1-23 Functional implications of polygenic risk for schizophrenia in human neurons
by PJ Michael Deans & Kayla G. Retallick-Townsley & Aiqun Li & Carina Seah & Jessica Johnson & Judit Garcia Gonzalez & Evan Cao & Nadine Schrode & Alex Yu & Sam Cartwright & Georgios Voloudakis & Wen Zhang & Minghui Wang & John F. Fullard & Kiran Girdhar & Eli Stahl & Schahram Akbarian & Bin Zhang & Panos Roussos & Paul O’Reilly & Laura M. Huckins & Kristen J. Brennand
- 1-23 GPR4 promotes immune exclusion in colon cancer through LOXL2-mediated extracellular matrix remodeling
by Shuheng Bai & Min Chen & Xuan Wang & Ning Lan & Ruijie Meng & Yanli Yan & Wanyi Liu & Wenyang Li & Fang Wu & Xiangxiang Zhang & Fengyuan Hu & Rong Li & Juan Ren
- 1-23 Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration
by Shai Kaluski-Kopatch & Daniel Stein & Alfredo Garcia Venzor & Ana Margarida Ferreira Campos & Melanie Planque & Bareket Goldstein & Estefanía De Allende-Becerra & Dmitrii Smirnov & Adam Zaretsky & Ekaterina Eremenko & Miguel Portillo & Monica Einav & Alena Bruce Krejci & Uri Abdu & Ekaterina Khrameeva & Daniel Gitler & Sarah-Maria Fendt & Debra Toiber
- 1-23 In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy
by Yue Chen & Qinyi Chen & Yuanyuan Ma & Cheng Zhang & Jie Xu & Kejing Li & Yajie Sun & Xinge Su & Mingguang Wei & Rui Bao & Tong Ding & Longguang Tang & Wenying Yu & Shenghong Ju & Wenpei Fan
- 1-23 High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infection
by Cong Han & Yongqi Wang & Shihuan Gao & Ting Wang & Huili Du & Jie Long & Weidong Tian & Mohsen Adeli & Liang Cheng & Zhi Liu & Tian Chen & Chong Cheng
- 1-23 Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program
by Nana Zhang & Ran Zhao & Xiaomin Zhong & Qian Dong & Yajie Liu & Kairan Yu & Lirui Han & Fanxu Meng & Jiaxuan Wu & Qiushi Chen & Xuechen Li & Qingbin Chen & Keren Zhang & Huang Huang & Jianing Zhang & Sijin Wu & Yan Ren & Wei Wang & Yubo Liu
- 1-23 Analysis of medieval burials from Ibiza reveals genetic and pathogenic diversity during the Islamic period
by Ricardo Rodríguez-Varela & Zoé Pochon & Alex Mas-Sandoval & Reyhan Yaka & Cesar A. Fortes-Lima & Almudena García Rubio & Nicholas Márquez-Grant & Juanjo Marí & Glenda Graziani & Antoni Ferrer Abárzuza & Mário Vicente & Lander Lorca-Francisco & Anna Linderholm & Vendela K. Lagerholm & Lara R. Arauna & Patxi Pérez-Ramallo & Maja Krzewińska & Carina M. Schlebusch & Anders Götherström
- 1-23 Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment
by Peng Cao & Qilin Li & Yuyu Li & Honglian Guo & Chunyu Wei & Rengui Xu & Chenke Ouyang & Wei Chen & Lin Wang & Zheng Wang
- 1-23 Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm
by Joanna Szpotkowska & Wojciech J. Szlachcic & Katarzyna Blaszczyk & Maja Baginska & Magdalena Socha & Malgorzata Borowiak
- 1-23 Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
by Sathish Babu Vasamsetti & Samreen Sadaf & Mohammad A. Uddin & Jixing Shen & Ebin Johny & Awishi Mondal & Jonathan Florentin & Liqun Lei & Aleef Mannan & Krithika Sudhakar Rao & John Sembrat & Mauricio Rojas & Ian Sipula & Jake Kastroll & Michael J. Jurczak & Sruti Shiva & Robert M. O’Doherty & Vijay Yechoor & Partha Dutta
- 1-23 Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2
by Sam E. J. Paton & José L. Solano & Alice Cadoret & Adeline Collignon & Luisa Bandeira Binder & Béatrice Daigle & Laura Menegatti Bevilacqua & Émanuelle Richer & François Coulombe-Rozon & Laurence Dion-Albert & Katarzyna A. Dudek & Manon Lebel & Caroline Ménard
- 1-23 Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression
by Vincent Cuminetti & Emeline Boet & Marcel Heugel & Joanna Konieczny & Aurora Bernal & Manuel J. Gomez & Franco Grimolizzi & Nuria Vilaplana-Lopera & Marc Ferré & Alicia Villatoro & Deo P. Pandey & Carlos Torroja & Hagar Taman & Ruth H. Paulssen & Thomas Vogl & Caroline A. Heckman & Anders Vik & Giovanna Giovinazzo & Nick van Gastel & Paloma García & Fátima Sánchez-Cabo & Jean-Emmanuel Sarry & Lorena Arranz
- 1-23 Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state
by Ludivine Bersier & L. Francisco Lorenzo-Martin & Yi-Hsuan Chiang & Stephan Durot & Aleksander Czauderna & Tural Yarahmadov & Tania Wyss Lozano & Irena Roci & Jaeryung Kim & Nicola Zamboni & Nicola Vannini & Caroline Pot & Tinh-Hai Collet & Deborah Stroka & Jeremiah Bernier-Latmani & Matthias P. Lutolf & Simone Becattini & Thibaud Koessler & Tatiana V. Petrova
- 1-23 Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming
by Mark Rusznak & Shinji Toki & Yajing Hao & Marc J. C. Todd & Liddy Malone & Julia F. Goodhead & Catherine DuPuy & Weisong Zhou & Dominique Babin & Christian M. Warren & Masako Abney & Matthew T. Stier & Christopher M. Thomas & Jing Li & Justin Jacobse & Andrew P. Pahnke & Mark I. Petrovic & Jacqueline-Yvonne Cephus & Shelby N. Kuehnle & M. Wade Calcutt & Allison E. Norlander & Fang Yan & Jeremy A. Goettel & Darla R. Miller & Rachel M. Lynch & Daniel P. Cook & Dawn C. Newcomb & Fei Zou & R. Stokes Peebles Jr
- 1-23 Discovering the complete enhancer map of human herpesviruses using a natural language processing model
by Nilabja Roy Chowdhury & Deepanway Ghosal & Vyacheslav Gurevich & Meir Shamay
- 1-23 Comparative multi-omic analysis reveals conserved and derived mechanisms of fin and limb regeneration
by Josane F. Sousa & Gabriela Lima & Louise Perez & Hannah Schof & Igor Schneider
- 1-23 Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam
by Philipp Kruppa & Rachelle Crescenzi & Gabriele Faerber & Isabel Forner-Cordero & Manuel Cornely & Ramin Shayan & Tara Karnezis & Jose Luis Simarro & Paula Frederichi de Souza & Karen Louise Herbst & Mojtaba Ghods & Sandro Michelini
- 1-23 Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice
by Yawen Li & Hui Wang & Dongyuan Zhang & Shiqi Wang & Zheng Li & Jingjie Li & Shentao Tai & Dandan Tong & Bifeng Wang & Dingbing Lu & Shulu Yuan & Weiqi Sun & Biyu Yang & Chaobo Bai & Qi Wang & Jiuyang Ding & Zhihao Wang & Yang Gao & Haitao Yu & Kun Cui & Chang Liu & Jian Mao & Yun Yao & Fengyu Liu & You Wan & Junliang Yuan & Xuemei Liu & Jie Zheng
- 1-23 Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer
by Pratishtha Singh & Ranit D’Rozario & Bidisha Chakraborty & Swadhin Meher & Deblina Raychaudhuri & Aminah J. Tannir & Yang Li & Anurag Majumdar & Jessalyn Hawkins & Yun Xiong & Philip Lorenzi & Padmanee Sharma & Kadir Akdemir & Patrick Pilie & Abhinav K. Jain & Byron Hing Lung Lee & Sangeeta Goswami
- 1-23 RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
by Chi Yan & Weifeng Luo & Jinming Yang & Jing Yang & Sheau-Chiann Chen & Kensey Bergdorf & Qianni Hu & Vivian L. Weiss & Douglas B. Johnson & Qi Liu & Ann Richmond
- 1-23 Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator
by Mriga Dutt & Luoping Liao & Hani Jieun Kim & Ronnie Blazev & Audrey Chan & Hitesh Kore & Ayenachew Bezawork-Geleta & Li Dong & Isela Sarahi Rivera & Natalie K. Y. Wee & Jeffrey Molendijk & Julian P. H. Wong & Vanessa R. Haynes & Veronica Uribe & Gordon S. Lynch & Kelly A. Smith & Magdalene K. Montgomery & Matthew J. Watt & Pengyi Yang & Garron T. Dodd & Stephin J. Vervoort & Natalie A. Sims & Benjamin L. Parker
- 1-23 Versican expression from lung fibroblasts suppresses pulmonary fibrosis
by Paraskevi Kanellopoulou & Ilianna Barbayianni & Dionysios Fanidis & Martina Samiotaki & Eleni Katsiouli & Dimitris Nastos & Stefanos Smyrniotis & Maria Shira & Apostolos Galaris & Vagelis Rinotas & Sofia Grammenoudi & Christiana Magkrioti & Ioannis Tomos & Africa Martinez Blanco & Ioanna Tremi & Ioannis Vamvakaris & Nuria Gavara & Sophia Havaki & Vassilis Gorgoulis & Hideto Watanabe & Vassilis Aidinis
- 1-23 Recurrent connections facilitate occluded object recognition by explaining-away
by Byungwoo Kang & Benjamin Midler & Feng Chen & Shaul Druckmann
- 1-24 FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing
by Pierre Parutto & Yutong Yuan & Valentina Davì & Roger Pons-Lanau & Svenja Ebeling & Karnika Gupta & Francesca Bottanelli & Maria F. Garcia-Parajo & Felix Campelo & Clemens F. Kaminski & Joseph E. Chambers & Jonathon Nixon-Abell & Edward Avezov
- 1-24 A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation
by Isabel Stötzel & Ann-Kathrin Weier & Apurba Sarkar & Subhendu Som & Luisa Bach & Peter Konopka & Eliška Miková & Shaunak Ghosh & Jan Böthling & Mirka Homrich & Laura Schaedel & Uli Kazmaier & Konstantinos Symeonidis & Stefan Ebner & Philip Weidner & Zeinab Abdullah & Felix Meissner & Stefan Uderhardt & Miroslav Hons & Dirk Baumjohann & Raja Paul & Heiko Rieger & Eva Kiermaier
- 1-24 Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina
by Bhakta Prasad Gaire & Yosef Koronyo & Jean-Philippe Vit & Alexandre Hutton & Lalita Subedi & Dieu-Trang Fuchs & Natalie Swerdlow & Altan Rentsendorj & Saba Shahin & Daisy Martinon & Edward Robinson & Alexander V. Ljubimov & Julie A. Schneider & Lon S. Schneider & Debra Hawes & Stuart L. Graham & Vivek K. Gupta & Mehdi Mirzaei & Keith L. Black & Jesse G. Meyer & Moshe Arditi & Timothy R. Crother & Maya Koronyo-Hamaoui
- 1-24 Combinatory differentiation of human induced pluripotent stem cells generates functional thymic epithelium driving dendritic cell and CD4/CD8 T cell development
by Nathan Provin & Manon d’Arco & Antoine Le Bozec & Erwan Kervagoret & Alexandre Bruneau & Lucas Brusselle & Cynthia Fourgeux & Jeremie Poschmann & Philippe Hulin & Pierre Maminirina & Olivier Baron & Xavier Saulquin & Carole Guillonneau & Laurent David & Matthieu Giraud
- 1-24 Palmitic acid-triggered B7H3 palmitoylation promotes immune escape
by Zejun Rao & Changsheng Huang & Qi Wu & Mao Li & Anyi Liu & Tong Zhu & Wangshuo Yang & Lanlan Yin & Shengyu Zhu & Xiaowei She & Chengxin Yu & Lang Liu & Pengcheng Li & Yucong Bai & Dongjing Zhang & Tianci Xie & Xiang Liu & Lu Liu & Feng Xu & Guihua Wang & Junbo Hu & Xuelai Luo
- 1-24 Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration
by Nikolaos Tsopoulidis & Masaki Yagi & Justin Brumbaugh & Shinya Ito & Víctor López-Soriano & Robert Morris & Yoseop Yoon & Kathleen A. Messemer & Kuan-Hung Lin & Eric F. Zaniewski & Rebecca Gorelov & Aaron J. Huebner & Amy J. Wagers & Hanno Hock & Günter Kramer & Bernd Bukau & Michael S. Hoetker & Yongsheng Shi & Wilhelm Haas & Konrad Hochedlinger
- 1-24 Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway
by Ziqi Zhang & Xue li & Tianqi Lu & Jingyun Yang & Xuejiao Han & Zhenfei Bi & Jingwen Luo & Aqu Alu & Weiqi Hong & Siyuan Chen & Lei Chen & Yuan Cheng & Xuemei He & Chenjing Zhu & Manni Wang & Qingfang Li & Yang Wang & Lu Li & Hong Lei & Jie Lan & Jia Geng & Yuquan Wei & Xiawei Wei
- 1-24 Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer
by Jia-Jia Zhang & Ruo-Fei Tian & Chang-Geng Song & Rui Liu & Duo He & Gai-Qin Zhang & Xin-Yu Fan & Zi-Chuan Duan & Kun Zhang & Tian-Jiao Zhang & Ya-Tong Chen & Jian Zhang & Ke Wang & Ju-Mei Zhao & Xiang-Min Yang & Zhi-Nan Chen & Ling Li
- 1-24 Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex
by Rakenduvadhana Szrinivasan & Kalevi Trontti & Rémi Mathieu & Tangra Draia-Nicolau & Genevieve Chazal & Säde Loukasmäki & Silvana Bodington Celma & Kaia Achim & Pavel Uvarov & Stanislav Khirug & Anastasia Ludwig & Sari E. Lauri & Antoine de Chevigny & Olli Pietiläinen & Claudio Rivera
- 1-24 Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair
by Minjun Kwak & Eunjun Choi & Yemin Jo & Boa Kim & Chaeryeong Lim & Jooyoung Lim & Yoon Ha Choi & Jung Hyun Lee & Kee-Pyo Kim & Bon-Kyoung Koo & Jong Kyoung Kim & Sekyu Choi
- 1-24 The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization
by Giulia Baracchini & Yigu Zhou & Jason da Silva Castanheira & Justine Y. Hansen & Can Fenerci & Roni Setton & Jenny R. Rieck & Gary R. Turner & Cheryl L. Grady & Bratislav Misic & Jason S. Nomi & Lucina Q. Uddin & R. Nathan Spreng
- 1-24 Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions
by Yuxiang Liang & Zhaowei Yu & Shaobo Du & Yuqian Guo & Jing Li & Yujia Yan & Shanshan Jin & Wenjing Liang & Mengyuan Li & Ning Jin & Jiao Yang & Zhiwei Peng & Zhaoyang Chen & Hailan Yang & Zhizhen Liu & Qizhi Shuai & Liping Li & Jun Xie
- 1-24 Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
by Irene Schwartz & Valentina Budroni & Mathilde Meyenberg & Zuzana Hodakova & Harald Hornegger & Kathrin Hacker & Siegfried Schwartz & Daniel B. Grabarczyk & Julian F. Ehrmann & Sara Scinicariello & David Haselbach & Jörg Menche & Tim Clausen & G. Elif Karagöz & Gijs A. Versteeg
- 1-24 The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
by Typhanie Dumontet & Kaitlin J. Basham & Micah C. Foster & Emma Silverman & Kyle A. Heard & Dominque Johnson & Chaelin Lee & Samuel W. Plaska & David T. Breault & David Penton & Felix Beuschlein & Adina F. Turcu & Christopher R. LaPensee & Antonio Marcondes Lerario & Gary D. Hammer
- 1-24 AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape
by Mohammad Sufyan Ansari & Varnit Chauhan & Aashi Singh & Areej Akhtar & Nisha Chaudhary & Reegina Tyagi & Divya & Kashif Husain & Sheetal Sharma & Ruquaiya Alam & Md Shakir & Mehak Pracha & Samreen Anjum & Mohd Nadeem & Prial Taneja & Md Imam Faizan & Iqbal Azmi & Aditya Ramdas Iyer & Pragya Gupta & Mehwish Nafiz & Shayan Ali & Insha Mohi Uddin & Momina Javid & Zahoor Ahmad Bhat & Hamenth Kumar Palani & Amit Kumar Srivastava & Ulaganathan Mabalirajan & Vikram Mathews & Mohammad Husain & Sivaprakash Ramalingam & Gaurav Kharya & Tanveer Ahmad
- 1-24 Efficient high-precision transgene knock-in by Recombinases (Redα/β)-enhanced DNA integration-CRISPR-Cas9 (RED-CRISPR)
by Wenqing Li & Senquan Liu & Xiaoyu Fang & Jiaqi Zou & Qin Jiang & Xiaolin Min & Xiaoli Zhu & Yuzhu Cao & Xiaoxiao Gao & Wenjie Han & Muhammad Azhar & Xuemei Xing & Fudong Li & Youming Zhang & Hongbin Liu & Linzhao Cheng & Chengkun Wang & Jianqiang Bao
- 1-24 Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice
by Kierra Ware & Joshua Peter & Jake Yazell & Christina Thapa & Aleksandr Taranov & Alicia Bedolla & Claire Distel & Sven Lammich & Regina Feederle & Alice Sülzen & Shane Liddelow & Krishna Roskin & Yu Luo
- 1-24 Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification
by Anthony Osuma & Honorine Destain & Jessica Mann & Yinan Li & Seth R. Taylor & Manasa Prahlad & Ian Q. Weigle & Filipe Marques & Natalie Grace Schulz & Laura D. Mathies & Priota Islam & André E. X. Brown & Jayson J. Smith & Paschalis Kratsios
- 1-24 Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration
by Qiangqiang Guo & Wei Wang & Xinzhao Jiang & Jincheng Tang & Feng Cai & Wenbo Wang & Lichen Zhang & Ziang Li & Yiyang Huang & Jie Wu & Liang Zhou & Haochen Jiang & Yiwei Zhu & Guhao Cai & Ziyu Lin & Yong Gu & Xuesong Zhu & Liang Chen & Kun Xi
- 1-25 Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis
by Haoning Peng & Zhile Wang & Mengyao Wang & Zheyu Ding & Kaixiu Li & Yuqing Wang & Xuejiao Yu & Siyang Song & Yulan Deng & Yi Liu & Qiang Pu & Lu Li & Michael Cerezo & Weiya Wang & Lunxu Liu & Shensi Shen
- 1-25 An in vivo and in vitro spatiotemporal profile of human midbrain development
by Dimitri Budinger & Pau Puigdevall & George T. Hall & Charlotte Roth & Theodoros Xenakis & Elena Marrosu & Julie Jerber & Alessandro Di Domenico & Francesca Picco & Helena Kilpinen & Sergi Castellano & Manju A. Kurian & Serena Barral
- 1-25 Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis
by Masaki Nishioka & Mie Sakashita-Kubota & Kouichirou Iijima & Yukako Hasegawa & Mizuho Ishiwata & Kaito Takase & Ryuya Ichikawa & Naguib Mechawar & Gustavo Turecki & Tadafumi Kato
- 1-25 Energy-sensing molecule RORγ regulates cholesterol metabolism and immune signaling in diabetic kidney disease and aging
by Zhen Liang & Jiaqing Xiang & Guangyan Yang & Xiaomai Liu & Lixing Li & Yanchun Li & Yan Lu & Lin Kang & Yuanli Chen & Chuanrui Ma & Shu Yang
- 1-25 GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesis
by Hai-Tao Xiao & Peng Song & Jing Jin & Yong-Dan Wang & Yin-Yue Xu & He Wu & Xue-Xue Shao & Qi-Feng Gan & Jian He & Yan-Rong Wen & Jing Zhu & Bao-Yi Chen & Ping Zhou & Li-Na Lai & Hua Yang & Ping Li & Zu-Guo Zheng
- 1-25 Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial
by Linda Klümpen & Aakash Mantri & Maren Philipps & Waldemar Seel & Laura Schlautmann & Mohamed H. Yaghmour & Verena Wiemann & Birgit Stoffel-Wagner & Martin Coenen & Leonie Weinhold & Jan Hasenauer & Thomas Fließwasser & Sven Burgdorf & Christoph Thiele & Peter Stehle & Marie-Christine Simon
- 1-25 Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar
by Yixuan Yuan & Yujie Xiao & Jie Zou & Liang Luo & Mengyang Li & Kuo Shen & Lai Wei & Yihao Zhang & Peng Wang & Yan Chen & Shixuan Zhuo & Hao Zhang & Shijie Song & Yanhui Jia & Kejia Wang & Shiqing Jiang & Hao Guan & Dahai Hu
- 1-26 Phylogenomic profile of exon-intron organization across angiosperms, their relationships with protein domains, and functional implications
by Taikui Zhang & Lin Zhang & Hong Ma & Jun Wang
- 1-26 Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
by Eok-Cheon Kim & Han-Byul Jung & Yu-kyoung Park & Youlim Son & Hye-Na Cha & Yash Patel & Ju Hee Lee & Minah Choi & Soyoung Park & Il-Kug Kim & Lauren Pickel & Seungju Lee & Yuna Ha & Min-Gyeong Shin & Qiwei Zhang & Jielin Yang & Bruno Rodrigues de Oliveira & Nathaniel Vo & Annie Yew & Jacques Togo & Kafi N. Ealey & Su-Ryun Jung & Sunjin Moon & Hye-Jin Yoon & Jee-Young Lee & Hoon-Ki Sung & Jae-Ryong Kim & So-Young Park
- 1-26 Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway
by Sun Yi & Huang Wen Xin & Qigang Fan & Xiaoping Yue & Yanbing Lin & Xueyu Chen & Jun Xie & Peize Li & Shuaishuai Xing & Yang Chen & Qiong Lei & Manli Wang & Guo Geng & Zhao De peng & Zhang Hui dong
- 1-26 CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
by Linjie Luo & Yan Wang & Tuyen Bui & Xiaoting Jiang & Mei-Kuang Chen & Xiayu Rao & Sepideh Mohammadhosseinpour & Mi Li & Serena Kim & Rachel Y. Kim & Saba Kamaliasl & Carmen W. Ulizio & Spyros Tsavachidis & Juliana Navarro-Yepes & Nicole M. Kettner & Hannah Wingate & Funda Meric-Bernstam & Kelly K. Hunt & Jing Wang & Kerrie Faia & Khandan Keyomarsi
- 1-26 Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity
by Yonghua Li & Min Sheng & Weijie Li & Simin Liu & Botao Wang & Bing Liu & Mei Luo & Xiao Zhou & Qiaoxi Xia & Shihong Hong & Ziyuan Zheng & Shi-Yuan Cheng & Xiaobing Jiang & Junjun Li & Tianzhi Huang
- 1-26 Pan-RAF inhibitor exarafenib targets BRAF class II/III NSCLC and reveals ARAF-KSR1 resistance and combination strategies
by Tadashi Manabe & Hannah C. Bergo & Qingtian Li & Tim Sen Wang & Paul Severson & Nichol Miller & Catherine Lee & Elifnur Yay Donderici & Nicole Zhang & Wei Wu & Yu-Ting Chou & Daniel L. Kerr & Paul Allegakoen & Kathryn B. Grandinetti & Liliana Soroceanu & Robert J. Pelham & Eric S. Martin & Eric A. Murphy & Vishesh Khanna & Joel W. Neal & Christopher T. Chen & Shumei Kato & Richard Williams & Trever G. Bivona
- 1-26 Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes
by Jianing Li & Anthony F. Tanzillo & Giusy Pizzirusso & Adam Caccavano & Ramesh Chittajallu & Mira Sohn & Daniel Abebe & Yajun Zhang & Kenneth A. Pelkey & Ryan K. Dale & Chris J. McBain & Timothy J. Petros
- 1-26 Discovery of NIRF theranostic probes targeting amyloid-β and cholinesterases in Alzheimer’s disease models
by Himanshu Rai & Rishabh Singh & Gauri Shankar & Sanskriti Rai & Prabhat Kumar & Aishwarya S. Nilakhe & Neha Singh & Poonam Bhadoria & Gourav Singh & Venkatnarayan Ramanathan & Sarika Gupta & Sairam Krishnamurthy & Saripella Srikrishna & Saroj Kumar & Gyan Modi
- 1-26 Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design
by Linling He & Yi-Zong Lee & Yi-Nan Zhang & Maddy L. Newby & Benjamin M. Janus & Fabrizio G. Gonzalez & Garrett Ward & Connor DesRoberts & Shr-Hau Hung & Erick Giang & Joel D. Allen & Liudmila Kulakova & Eric A. Toth & Thomas R. Fuerst & Mansun Law & Gilad Ofek & Max Crispin & Jiang Zhu
- 1-26 A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities
by Zhenyu Yang & Shiyou Wei & Hao Duan & Xiuqi Wang & Dainan Zhang & Karrie Mei-Yee Kiang & Yulan Deng & Yuanzhong Yang & Yin Ku & Wanming Hu & Chaowei Zou & Meiqin Tang & Yu Jiang & Yu Liu & Hongbin Lan & Zexin Chen & Gilberto Ka-Kit Leung & Wang Jia & Yonggao Mou & Lunxu Liu & Gao Zhang
- 1-27 Printing technologies for monitoring crop health
by David Panáček & Vojtěch Kupka & Martin-Alex Nalepa & Ivan Dědek & Ruslan Álvarez-Diduk & Selin Olenik & Jose Flauzino & Jan Zdražil & Petr Jakubec & Lukáš Zdražil & Lukáš Spíchal & Keval K. Sonigara & Radek Zbořil & Martin Pumera & Arben Merkoçi & Joseph Wang & Nuria De Diego & Firat Güder & Michal Otyepka
- 1-27 Escherichia coli promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps
by Banglun Pan & Yuxin Yao & Zhu Zhang & Dongjie Ye & Hao Wu & Xinyu Zhang & Xiaoqian Wang & Nanhong Tang
- 1-27 Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum
by Cecilia P. Sanchez & Maëlle Duffey & Romina V. Celada & Michal Kucharski & Marie Hoarau & Thanaya Saeyang & Sumalee Kamchonwongpaisan & Farzin Sohraby & Svenja de Buhr & Ariane Nunes Alves & Amuza Byaruhanga Lucky & Jun Miao & Clement Regnault & Jerzy M. Dziekan & Zbynek Bozdech & Michael P. Barrett & Michael Lanzer
- 1-27 Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure
by Manju Kumari & Ioannis Evangelakos & Anushka Deshpande & Kirstie A. De Jong & Nesrin Schmiedel & Nicolàs Palacio-Escat & Adriano de Britto Chaves-Filho & Roberto Carlos Frias-Soler & Glynis Klinke & Hyun Cheol Roh & Luisa Lange & Michael Berlin & Marceline M. Fuh & Jakob Johannes Buss & Tian Tian & Carolin Lerchenmüller & Marc Freichel & Almut Schulze & Viacheslav O. Nikolaev & Thomas Eschenhagen & Evan D. Rosen & Ludger Scheja & Ashraf Yusuf Rangrez & Joerg Heeren & Norbert Frey
- 1-27 Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice
by Cristina Cuesta-Marti & Eduardo Ponce-España & Friederike Uhlig & Iris Stoltenborg & Luiza A. Wasiewska & Lamiah Kareem & Dara Hedayatpour & Loreto Olavarría-Ramírez & Cristina Rosell-Cardona & Thomaz. F. S. Bastiaanssen & Gabriel. S. S. Tofani & Benjamin Valderrama & Klara Vlckova & Suzanne L. Dickson & Aonghus Lavelle & Catherine Stanton & R. Paul Ross & John F. Cryan & Timothy G. Dinan & Gerard Clarke & Siobhain M. O’Mahony & Harriët Schellekens
- 1-28 Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection
by Haoyi Chen & Li Wei & Qiang Yu & Chenxi Wang & Huizhen Fan & Ming Li & Ruonan Dong & Yingying Ma & Jiahao Jiang & Lianfu Deng & Mei X. Wu & Min Lu
- 1-28 The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex prediction
by Adriano Setti & Giorgio Bini & Flaminia Pellegrini & Valentino Maiorca & Gabriele Proietti & Dimitrios-Miltiadis Vrachnos & Angelo D’Angelo & Alexandros Armaos & Julie Martone & Michele Monti & Giancarlo Ruocco & Emanuele Rodolà & Irene Bozzoni & Alessio Colantoni & Gian Gaetano Tartaglia
- 1-28 Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage
by Irina Poverennaya & Aliia Murtazina & Lei Li & Lorena Maili & Lukas Sourada & Luis Fernando Montano-Gutierrez & Rozalina Galimullina & Tobias Steinschaden & Marketa Kaiser & Tomas Zikmund & Adna Goralija & Teng Gao & Aurore Attina & Ornella Clara & Christoph Bartenhagen & Alek Erickson & Yaakov Gershtein & Shiyuan Chen & Kristyna Polaskova & Jaroslav Sterba & Bettina Semasch & Emma R. Anderson & Varsha Prakash & Theresa Vincent & Maria Arceo & Per Kogner & Susanne Schlisio & Peter V. Kharchenko & Alexandre David & Jozef Kaiser & Matthias Fischer & Jan Skoda & Paul A. Trainor & Andrei S. Chagin & Igor Adameyko
- 1-30 Robust characterization and interpretation of rare pathogenic cell populations from spatial omics using GARDEN
by Xinming Zhang & Zhuohan Yu & Gaoyang Hao & Qi Yao & Yanmei Hu & Fuzhou Wang & Xingjian Chen & Linjing Liu & Ka-Chun Wong & Xiangtao Li
- 1-30 Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering
by Jie Li & Zishuo Wang & Wenjing Yang & Yuchen Zhang & Yanjun Wang & Xuhui Wang & Hongrui Wang & Yang Xie & Shuogui Xu & Yan Shang & Chunyu Xue & Yuntong Zhang & Shuo Fang
- 1-30 Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol
by Jing Lan & Jiaqi Wang & Sijuan Huang & Chenyu Li & Ziteng Deng & Zhihui Hao & Yunfei Ma
- 1-30 Developments and challenges in hit progression within fragment-based drug discovery
by Harold Grosjean & Philip C. Biggin
December 2025, Volume 16, Issue 1
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