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Economic Evaluation of Tirbanibulin for the Treatment of Actinic Keratosis in Scotland

Author

Listed:
  • Amy Dymond

    (York Health Economics Consortium)

  • Will Green

    (York Health Economics Consortium)

  • Mary Edwards

    (York Health Economics Consortium)

  • Maria Angeles Lopez Pont

    (Almirall SA)

  • Girish Gupta

    (The University of Edinburgh)

Abstract

Background Tirbanibulin 1% ointment is a new treatment for actinic keratosis (AK) on the face or scalp. A health economic model was developed as part of a submission to the Scottish Medicines Consortium to evaluate the cost-effectiveness of tirbanibulin compared to the most frequently prescribed treatments. Methods A decision tree approach was used to calculate the costs and benefits of different treatment strategies for AK on the face or scalp over a one-year time horizon. Data on the relative efficacy of treatments, which were based on the probability of complete clearance of AK, were obtained from a network meta-analysis. Sensitivity and scenario analyses were performed to determine the robustness of the model results. Results Tirbanibulin is estimated to be cost saving versus diclofenac sodium 3%, imiquimod 5% and fluorouracil 5%. Tirbanibulin remains cost saving when inputs are varied in sensitivity and scenario analyses. While the complete clearance rates are deemed similar across comparators, tirbanibulin is associated with a lower rate of severe local skin reactions, and a shorter treatment duration, which may improve treatment adherence. Conclusions Tirbanibulin is a cost saving intervention for the treatment of AK from the perspective of the Scottish Healthcare System.

Suggested Citation

  • Amy Dymond & Will Green & Mary Edwards & Maria Angeles Lopez Pont & Girish Gupta, 2023. "Economic Evaluation of Tirbanibulin for the Treatment of Actinic Keratosis in Scotland," PharmacoEconomics - Open, Springer, vol. 7(3), pages 443-454, May.
    • Handle: RePEc:spr:pharmo:v:7:y:2023:i:3:d:10.1007_s41669-023-00410-5
    DOI: 10.1007/s41669-023-00410-5
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    References listed on IDEAS

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    1. Paul Kind & Geoffrey Hardman & Susan Macran, 1999. "UK population norms for EQ-5D," Working Papers 172chedp, Centre for Health Economics, University of York.
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