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A Systematic Review and Critical Assessment of Health State Utilities

Author

Listed:
  • Scott Doyle

    (Oxford Outcomes
    University of Oxford)

  • Andrew Lloyd

    (Oxford Outcomes)

  • Lee Moore

    (Roche Products Ltd.)

  • Joshua Ray

    (F. Hoffmann-La Roche Ltd.)

  • Alastair Gray

    (University of Oxford)

Abstract

Objective The study aimed to conduct a systematic literature search to identify health state utilities for weight change in type 2 diabetes mellitus (T2DM) and to review those values for appropriateness for inclusion in a submission to the National Institute for Health and Clinical Excellence (NICE). Methods The search was conducted using keywords and Medical Subject Heading (MeSH) terms designed to exhaustively capture health state utility values across a variety of known economic, health technology assessment and peer-reviewed publication databases. The values were then critically reviewed from the perspective of the NICE reference case (2008 methods guide). Results The search resulted in a large number of repeat references across databases suggesting good sensitivity. Thirty-three articles were selected for inclusion and subjected to a critical review including their methodological quality, symmetry with the NICE reference case, sample size and country source. This critical review led to a shortlist of nine utility studies, all of which had potential for inclusion in cost-utility models or a meta-analysis. Conclusions A relatively large number of utilities have been collected in weight change and T2DM. Many of these utility values are not suitable for inclusion in a NICE submission. A better way of reviewing the methodological quality of utilities is needed.

Suggested Citation

  • Scott Doyle & Andrew Lloyd & Lee Moore & Joshua Ray & Alastair Gray, 2012. "A Systematic Review and Critical Assessment of Health State Utilities," PharmacoEconomics, Springer, vol. 30(12), pages 1133-1143, December.
    • Handle: RePEc:spr:pharme:v:30:y:2012:i:12:d:10.2165_11599420-000000000-00000
    DOI: 10.2165/11599420-000000000-00000
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    References listed on IDEAS

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    1. Alan Brennan & Roberta Ara & Raimund Sterz & Bernd Matiba & Rito Bergemann, 2006. "Assessment of clinical and economic benefits of weight management with sibutramine in general practice in Germany," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(4), pages 276-284, December.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    3. Adrian Bagust & Sophie Beale, 2005. "Modelling EuroQol health‐related utility values for diabetic complications from CODE‐2 data," Health Economics, John Wiley & Sons, Ltd., vol. 14(3), pages 217-230, March.
    4. Susan Macran, 2004. "The Relationship between Body Mass Index and Health-Related Quality of Life," Working Papers 190chedp, Centre for Health Economics, University of York.
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