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Evaluating the psychometric properties of the EQ-5D-5L and SF-6D among patients with haemophilia

Author

Listed:
  • Richard Huan Xu

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Dong Dong

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Nan Luo

    (National University of Singapore)

  • Eliza Lai-Yi Wong

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Yushan Wu

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Siyue Yu

    (The Chinese University of Hong Kong)

  • Renchi Yang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Junshuai Liu

    (Beijing Society of Rare Disease Clinical Care and Accessibility)

  • Huiqin Yuan

    (Beijing Society of Rare Disease Clinical Care and Accessibility)

  • Shuyang Zhang

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

Objective The aim of this study was to evaluate the psychometric properties of the EQ-5D-5L and SF-6D, and to compare their performance among patients living with haemophilia in China. Methods A total of 875 Chinese patients completed the EQ-5D-5L, SF-6D, and Haem-A-QoL questionnaires. Construct validity of the EQ-5D-5L and SF-6D dimensions and indices was assessed by testing hypotheses relating these measures to Haem-A-QoL and clinical measures. The Spearman correlation coefficient was used to assess convergent validity, and one-way analysis of variance (F statistic) was used to assess the known-groups validity (discriminatory power). The agreement between EQ-5D-5L and SF-6D indices was assessed using the intraclass correlation coefficient (ICC) and the Bland–Altman plot. Results Both the EQ-5D-5L and SF-6D indices showed acceptable ceiling and floor effects. As hypothesised, both EQ-5D-5L and SF-6D were significantly correlated with Haem-A-QoL (both dimensions and overall score). EQ-5D-5L and SF-6D indices as well as EQ-VAS differentiated patients are known to differ in severity of haemophilia, bleeding status, disabling levels, and comorbidity. The F statistics in the known-groups comparisons suggested that the EQ-5D-5L was slightly more discriminative than the SF-6D. ICC (0.41) and Bland–Altman plot confirmed that the agreement between the EQ-5D-5L and SF-6D indices was poor. Conclusion Both EQ-5D-5L and SF-6D showed satisfactory construct validity in the measurement of the HRQoL among patients with haemophilia. However, the two instruments may not be used interchangeably in this patient population due to their poor agreement and differing discriminatory power.

Suggested Citation

  • Richard Huan Xu & Dong Dong & Nan Luo & Eliza Lai-Yi Wong & Yushan Wu & Siyue Yu & Renchi Yang & Junshuai Liu & Huiqin Yuan & Shuyang Zhang, 2021. "Evaluating the psychometric properties of the EQ-5D-5L and SF-6D among patients with haemophilia," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(4), pages 547-557, June.
    • Handle: RePEc:spr:eujhec:v:22:y:2021:i:4:d:10.1007_s10198-021-01273-5
    DOI: 10.1007/s10198-021-01273-5
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    References listed on IDEAS

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    Cited by:

    1. Yin Ting Cheung & Pok Hong Lam & Henry Hon Wai Lam & Chung-Tin Ma & Alex Wing Kwan Leung & Raymond Siu Ming Wong & Chi Kong Li, 2022. "Treatment Adherence and Health-Related Quality of Life in Patients with Hemophilia in Hong Kong," IJERPH, MDPI, vol. 19(11), pages 1-13, May.
    2. Richard Huan Xu & Ming Lu & Shuyang Zhang & Dong Dong, 2023. "EQ-5D and SF-6D health utility scores in patients with spinal and bulbar muscular atrophy," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(8), pages 1399-1410, November.
    3. Richard Huan Xu & Yi Dai & Shamay S. M. Ng & Hector W. H. Tsang & Shuyang Zhang & Dong Dong, 2024. "Assessing validity of the EQ-5D-5L proxy in children and adolescents with Duchenne muscular dystrophy or spinal muscular atrophy," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 25(1), pages 103-115, February.
    4. Guizhi Weng & Yanming Hong & Nan Luo & Clara Mukuria & Jie Jiang & Zhihao Yang & Sha Li, 2023. "Comparing EQ-5D-3L and EQ-5D-5L in measuring the HRQoL burden of 4 health conditions in China," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(2), pages 197-207, March.

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    More about this item

    Keywords

    Haemophilia; Rare disease; Quality of life; EQ-5D; SF-6D; Psychometric property;
    All these keywords.

    JEL classification:

    • I10 - Health, Education, and Welfare - - Health - - - General

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