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Treatment Adherence and Health-Related Quality of Life in Patients with Hemophilia in Hong Kong

Author

Listed:
  • Yin Ting Cheung

    (School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China)

  • Pok Hong Lam

    (Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China)

  • Henry Hon Wai Lam

    (Hong Kong Haemophilia Society, Hong Kong, China)

  • Chung-Tin Ma

    (School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China)

  • Alex Wing Kwan Leung

    (Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Department of Paediatrics & Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, China
    Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China)

  • Raymond Siu Ming Wong

    (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China)

  • Chi Kong Li

    (Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Department of Paediatrics & Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, China
    Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong, China)

Abstract

Background: This study aims to identify factors affecting health-related quality of life (HRQoL) in Chinese patients with hemophilia in Hong Kong, and to examine the association between treatment adherence and HRQoL outcomes. Methods: Patients with hemophilia A or B from a non-governmental organization reported their HRQoL and treatment adherence to prophylactic therapy using validated tools. Univariate tests and multivariable regression analysis were used to compare differences in outcomes across clinically relevant subgroups. Results: Fifty-six patients were recruited (mean age 30.4 [17.4] years; majority hemophilia A: 75%; moderate-to-severe severity: 88%). Patients who received prophylactic treatment reported fewer work/school problems (25.8 [18.9] versus 51.5 [26.3]; p = 0.001) than those who received on-demand therapy. The multivariable model showed that older age ( B = 0.42, 95% CI = 0.093–0.75) and living in public housing ( B = 10.24, 95% CI = 0.70–19.77) were associated with worse HRQoL. Older age was associated with treatment non-adherence ( r = 0.66, p < 0.0001). Patients with poor adherence tended to report worse functioning in sports/leisure ( r = 0.31, p = 0.033). Conclusions: Our results suggest that patients who were older, had lower education attainment and received on-demand treatment had poorer perception of their health. Improving adherence may lead to better HRQoL. Future work includes evaluating the occupational needs prospectively in this population.

Suggested Citation

  • Yin Ting Cheung & Pok Hong Lam & Henry Hon Wai Lam & Chung-Tin Ma & Alex Wing Kwan Leung & Raymond Siu Ming Wong & Chi Kong Li, 2022. "Treatment Adherence and Health-Related Quality of Life in Patients with Hemophilia in Hong Kong," IJERPH, MDPI, vol. 19(11), pages 1-13, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6496-:d:825118
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    References listed on IDEAS

    as
    1. Richard Huan Xu & Dong Dong & Nan Luo & Eliza Lai-Yi Wong & Yushan Wu & Siyue Yu & Renchi Yang & Junshuai Liu & Huiqin Yuan & Shuyang Zhang, 2021. "Evaluating the psychometric properties of the EQ-5D-5L and SF-6D among patients with haemophilia," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(4), pages 547-557, June.
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