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Prevalence and Nature of Medication Errors and Medication-Related Harm Following Discharge from Hospital to Community Settings: A Systematic Review

Author

Listed:
  • Fatema A. Alqenae

    (University of Manchester)

  • Douglas Steinke

    (University of Manchester)

  • Richard N. Keers

    (University of Manchester
    Greater Manchester Mental Health NHS Foundation Trust)

Abstract

Background Little is known about the epidemiology of medication errors and medication-related harm following transition from secondary to primary care. This systematic review aims to identify and critically evaluate the available evidence on the prevalence and nature of medication errors and medication-related harm following hospital discharge. Methods Studies published between January 1990 and March 2019 were searched across ten electronic databases and the grey literature. No restrictions were applied with publication language or patient population studied. Studies were included if they contained data concerning the rate of medication errors, unintentional medication discrepancies, or adverse drug events. Two authors independently extracted study data. Results Fifty-four studies were included, most of which were rated as moderate (39/54) or high (7/54) quality. For adult patients, the median rate of medication errors and unintentional medication discrepancies following discharge was 53% [interquartile range 33–60.5] (n = 5 studies) and 50% [interquartile range 39–76] (n = 11), respectively. Five studies reported adverse drug reaction rates with a median of 27% [interquartile range 18–40.5] and seven studies reported adverse drug event rates with a median of 19% [interquartile range 16–24]. For paediatric patients, one study reported a medication error rate of 66.3% and another an adverse drug event rate of 9%. Almost a quarter of studies (13/54, 24%) utilised a follow-up period post-discharge of 1 month (range 2–180 days). Drug classes most commonly implicated with adverse drug events were antibiotics, antidiabetics, analgesics and cardiovascular drugs. Conclusions This is the first systematic review to explore the prevalence and nature of medication errors and adverse drug events following hospital discharge. Targets for future work have been identified.

Suggested Citation

  • Fatema A. Alqenae & Douglas Steinke & Richard N. Keers, 2020. "Prevalence and Nature of Medication Errors and Medication-Related Harm Following Discharge from Hospital to Community Settings: A Systematic Review," Drug Safety, Springer, vol. 43(6), pages 517-537, June.
  • Handle: RePEc:spr:drugsa:v:43:y:2020:i:6:d:10.1007_s40264-020-00918-3
    DOI: 10.1007/s40264-020-00918-3
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Sun-Joo Jang & Haeyoung Lee & Youn-Jung Son, 2021. "Perceptions of Patient Safety Culture and Medication Error Reporting among Early- and Mid-Career Female Nurses in South Korea," IJERPH, MDPI, vol. 18(9), pages 1-11, May.
    2. Olive Schmid & Bonnie Bereznicki & Gregory Mark Peterson & Jim Stankovich & Luke Bereznicki, 2022. "Persistence of Adverse Drug Reaction-Related Hospitalization Risk Following Discharge," IJERPH, MDPI, vol. 19(9), pages 1-12, May.
    3. Josephine Henry Basil & Chandini Menon Premakumar & Adliah Mhd Ali & Nurul Ain Mohd Tahir & Noraida Mohamed Shah, 2022. "Prevalence, Causes and Severity of Medication Administration Errors in the Neonatal Intensive Care Unit: A Systematic Review and Meta-Analysis," Drug Safety, Springer, vol. 45(12), pages 1457-1476, December.

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