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Preferences of Patients and Pharmacists with Regard to the Management of Drug–Drug Interactions: A Choice-Based Conjoint Analysis

Author

Listed:
  • Mette Heringa

    (SIR Institute for Pharmacy Practice and Policy
    Utrecht University
    Health Base Foundation)

  • Annemieke Floor-Schreudering

    (SIR Institute for Pharmacy Practice and Policy
    Utrecht University)

  • Hans Wouters

    (Groningen University)

  • Peter A. G. M. De Smet

    (University Medical Centre St Radboud)

  • Marcel L. Bouvy

    (SIR Institute for Pharmacy Practice and Policy
    Utrecht University)

Abstract

Introduction The management of drug–drug interactions (DDIs) is a complex process in which risk–benefit assessments should be combined with the patient’s perspective. Objective The aim of this study was to determine patients’ and pharmacists’ preferences regarding DDI management. Methods We conducted a choice-based conjoint survey about a fictitious DDI concerning the combination of a cardiovascular drug and an antibiotic for pneumonia. Patients and pharmacists had to choose 12 times between two management options. The options were described by five attributes, including risk, benefit and practical consequences. Each attribute could have two different levels, which were varied over the choice tasks. Latent class analysis was used to identify potential classes of respondents with distinct patterns of similar preferences. Results In total, 298 patients and 178 pharmacists completed the questionnaire. The latent class model for both patients and pharmacists resulted in three classes. For patients, in one class the most importance was attached to avoiding switch of medication (class probability 20%), in a second class to fewer adverse events (41%), and in a third class to blood sampling (39%). For pharmacists, again one class attached the highest importance to avoiding switch of medication (31%). The other classes gave priority to curing pneumonia (31%) and avoiding blood sampling (38%). Conclusion The results showed diverging preferences regarding DDI management among both patients and pharmacists. Different groups attached different value to risk and benefit versus practical considerations. Awareness of existing variability in preferences among and between pharmacists and patients is a step towards shared decision making in DDI management.

Suggested Citation

  • Mette Heringa & Annemieke Floor-Schreudering & Hans Wouters & Peter A. G. M. De Smet & Marcel L. Bouvy, 2018. "Preferences of Patients and Pharmacists with Regard to the Management of Drug–Drug Interactions: A Choice-Based Conjoint Analysis," Drug Safety, Springer, vol. 41(2), pages 179-189, February.
    • Handle: RePEc:spr:drugsa:v:41:y:2018:i:2:d:10.1007_s40264-017-0601-7
    DOI: 10.1007/s40264-017-0601-7
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    References listed on IDEAS

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    1. Mandy Ryan & Verity Watson & Vikki Entwistle, 2009. "Rationalising the ‘irrational’: a think aloud study of discrete choice experiment responses," Health Economics, John Wiley & Sons, Ltd., vol. 18(3), pages 321-336, March.
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    Cited by:

    1. van de Pol, Jeroen M. & Heringa, Mette & Koster, Ellen S. & Bouvy, Marcel L., 2021. "Preferences of patients regarding community pharmacy services: A discrete choice experiment," Health Policy, Elsevier, vol. 125(11), pages 1415-1420.

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