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Cost-Effectiveness of the Pneumococcal Vaccine in Healthy Younger Adults

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  • Patricia Vold Pepper
  • Douglas K. Owens

Abstract

Objectives Routine vaccination for Streptococcus pneumoniae has been recommended as a cost-effective measure for elderly and immunocompromised patients, yet no analysis has been performed for healthy younger adults in America. The authors evaluated the cost-effectiveness of the pneumococcal vaccine and determined the net health benefits conferred for the healthy young adult population. Methods The authors developed a decision model to compare the health and economic outcomes of vaccinate versus do not vaccinate for S. pneumoniae. Results Vaccinating patients for S. pneumoniae generates benefits that are dependent on incidence rates and the efficacy of the vaccine. In the 22-year-old patient with a pneumonia incidence of 0.3/1000, the vaccine would need to be >71 percent effective for the vaccination strategy to cost less than $50,000/QALY gained. At an incidence of 0.4/1000, the threshold efficacy is 53 percent, whereas at 0.5/1000 it is 43 percent. In the 35-year-old patient where the incidence of pneumococcal pneumonia is higher (0.85/1000), the vaccine would be cost-effective with an efficacy as low as 30 percent. Conclusions Use of the S. pneumoniae vaccine in young adults would provide modest reductions in pneumonia-associated morbidity and mortality. Vaccination of young adults is moderately expensive unless vaccine efficacy is above 50% to 60%. In 35-year-old adults, use of the vaccine is cost-effective even with moderate efficacy.

Suggested Citation

  • Patricia Vold Pepper & Douglas K. Owens, 2002. "Cost-Effectiveness of the Pneumococcal Vaccine in Healthy Younger Adults," Medical Decision Making, , vol. 22(1_suppl), pages 45-57, September.
    • Handle: RePEc:sae:medema:v:22:y:2002:i:1_suppl:p:45-57
    DOI: 10.1177/027298902237705
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    References listed on IDEAS

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    1. Dennis G. Fryback & Erik J. Dasbach & Ronald Klein & Barbara E.K. Klein & Norma Dorn & Kathy Peterson & Patrica A. Martin, 1993. "The Beaver Dam Health Outcomes study," Medical Decision Making, , vol. 13(2), pages 89-102, June.
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    Cited by:

    1. Paul E Sax & Alexis Sypek & Bethany K Berkowitz & Bethany L Morris & Elena Losina & A David Paltiel & Kathleen A Kelly & George R Seage III & Rochelle P Walensky & Milton C Weinstein & Joseph Eron & K, 2014. "HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-8, November.
    2. Ashleigh R Tuite & Ann N Burchell & David N Fisman, 2014. "Cost-Effectiveness of Enhanced Syphilis Screening among HIV-Positive Men Who Have Sex with Men: A Microsimulation Model," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-12, July.
    3. Marianela Castillo-Riquelme & Ariel Bardach & Alfredo Palacios & Andrés Pichón-Riviere, 2020. "Health burden and economic costs of smoking in Chile: The potential impact of increasing cigarettes prices," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-16, August.
    4. Hernandez-Vasquez, Akram, 2016. "Burden of smoking-related disease and potential impact of cigarette price increase in Peru," MPRA Paper 75677, University Library of Munich, Germany.
    5. Douglas K. Owens, 2002. "Analytic Tools for Public Health Decision Making," Medical Decision Making, , vol. 22(1_suppl), pages 3-10, September.

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