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HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?

Author

Listed:
  • Paul E Sax
  • Alexis Sypek
  • Bethany K Berkowitz
  • Bethany L Morris
  • Elena Losina
  • A David Paltiel
  • Kathleen A Kelly
  • George R Seage III
  • Rochelle P Walensky
  • Milton C Weinstein
  • Joseph Eron
  • Kenneth A Freedberg

Abstract

Background: We examined efficacy, toxicity, relapse, cost, and quality-of-life thresholds of hypothetical HIV cure interventions that would make them cost-effective compared to life-long antiretroviral therapy (ART). Methods: We used a computer simulation model to assess three HIV cure strategies: Gene Therapy, Chemotherapy, and Stem Cell Transplantation (SCT), each compared to ART. Efficacy and cost parameters were varied widely in sensitivity analysis. Outcomes included quality-adjusted life expectancy, lifetime cost, and cost-effectiveness in dollars/quality-adjusted life year ($/QALY) gained. Strategies were deemed cost-effective with incremental cost-effectiveness ratios

Suggested Citation

  • Paul E Sax & Alexis Sypek & Bethany K Berkowitz & Bethany L Morris & Elena Losina & A David Paltiel & Kathleen A Kelly & George R Seage III & Rochelle P Walensky & Milton C Weinstein & Joseph Eron & K, 2014. "HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0113031
    DOI: 10.1371/journal.pone.0113031
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    References listed on IDEAS

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    1. N. M. Archin & A. L. Liberty & A. D. Kashuba & S. K. Choudhary & J. D. Kuruc & A. M. Crooks & D. C. Parker & E. M. Anderson & M. F. Kearney & M. C. Strain & D. D. Richman & M. G. Hudgens & R. J. Bosch, 2012. "Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy," Nature, Nature, vol. 487(7408), pages 482-485, July.
    2. Patricia Vold Pepper & Douglas K. Owens, 2002. "Cost-Effectiveness of the Pneumococcal Vaccine in Healthy Younger Adults," Medical Decision Making, , vol. 22(1_suppl), pages 45-57, September.
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    Cited by:

    1. Donna E. Sweet & Frederick L. Altice & Calvin J. Cohen & Björn Vandewalle, 2016. "Cost-Effectiveness of Single- Versus Generic Multiple-Tablet Regimens for Treatment of HIV-1 Infection in the United States," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-19, January.

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