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Factors associated with catastrophic health expenditure in sub-Saharan Africa: A systematic review

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  • Paul Eze
  • Lucky Osaheni Lawani
  • Ujunwa Justina Agu
  • Linda Uzo Amara
  • Cassandra Anurika Okorie
  • Yubraj Acharya

Abstract

Objective: A non-negligible proportion of sub-Saharan African (SSA) households experience catastrophic costs accessing healthcare. This study aimed to systematically review the existing evidence to identify factors associated with catastrophic health expenditure (CHE) incidence in the region. Methods: We searched PubMed, CINAHL, Scopus, CNKI, Africa Journal Online, SciELO, PsycINFO, and Web of Science, and supplemented these with search of grey literature, pre-publication server deposits, Google Scholar®, and citation tracking of included studies. We assessed methodological quality of included studies using the Appraisal tool for Cross-Sectional Studies for quantitative studies and the Critical Appraisal Skills Programme checklist for qualitative studies; and synthesized study findings according to the guidelines of the Economic and Social Research Council. Results: We identified 82 quantitative, 3 qualitative, and 4 mixed-methods studies involving 3,112,322 individuals in 650,297 households in 29 SSA countries. Overall, we identified 29 population-level and 38 disease-specific factors associated with CHE incidence in the region. Significant population-level CHE-associated factors were rural residence, poor socioeconomic status, absent health insurance, large household size, unemployed household head, advanced age (elderly), hospitalization, chronic illness, utilization of specialist healthcare, and utilization of private healthcare providers. Significant distinct disease-specific factors were disability in a household member for NCDs; severe malaria, blood transfusion, neonatal intensive care, and distant facilities for maternal and child health services; emergency surgery for surgery/trauma patients; and low CD4-count, HIV and TB co-infection, and extra-pulmonary TB for HIV/TB patients. Conclusions: Multiple household and health system level factors need to be addressed to improve financial risk protection and healthcare access and utilization in SSA. Protocol registration: PROSPERO CRD42021274830

Suggested Citation

  • Paul Eze & Lucky Osaheni Lawani & Ujunwa Justina Agu & Linda Uzo Amara & Cassandra Anurika Okorie & Yubraj Acharya, 2022. "Factors associated with catastrophic health expenditure in sub-Saharan Africa: A systematic review," PLOS ONE, Public Library of Science, vol. 17(10), pages 1-28, October.
    • Handle: RePEc:plo:pone00:0276266
    DOI: 10.1371/journal.pone.0276266
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    References listed on IDEAS

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    2. Antonello Maruotti & Pierfrancesco Alaimo Di Loro & Cathleen Johnson, 2025. "Beyond catastrophic payments: modeling household health expenditure shares with endogenous selection," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 109(2), pages 363-386, June.
    3. Paul Eze & Stanley Ilechukwu & Lucky Osaheni Lawani, 2023. "Impact of community-based health insurance in low- and middle-income countries: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(6), pages 1-47, June.

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