IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0269169.html
   My bibliography  Save this article

Cost drivers associated with diffuse large B-cell lymphoma (DLBCL) in Japan: A structural equation model (SEM) analysis

Author

Listed:
  • Saaya Tsutsué
  • Shinichi Makita
  • Jingbo Yi
  • Bruce Crawford

Abstract

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin’s lymphoma of increasing prevalence in Japan. However, patients with relapsed or refractory disease to first line treatment (rrDLBCL) have been found to shoulder greater economic burden and have poor survival with subsequent lines of therapy. The relative impact of individual patient attributes on total medical cost among patients with rrDLBCL receiving second or third line (2L/3L) therapy was assessed. Structural equation modelling was used to identify potential cost drivers of total medical costs incurred by treatment and procedures in a Japanese retrospective claims database. From the database, rrDLBCL patients on 2L or 3L of treatment were grouped into respective cohorts. The mean [median] (SD) total medical cost of care for the 2L cohort was 73,296.40 [58,223.11] (58,409.79) US dollars (USD) and 75,238.35 [60,477.31] (59,583.66) USD for the 3L cohort. The largest total effect on medical cost in both cohorts was length of hospital stay (LOS) (β: 0.750 [95%CI: 0.728, 0.772] vs β: 0.762 [95%CI: 0.729, 0.794]). Length of hospital stay and potential heart disease complications due to line of treatment were the primary drivers of total cost for patients who had received at least 2L or 3L therapy for rrDLBCL.

Suggested Citation

  • Saaya Tsutsué & Shinichi Makita & Jingbo Yi & Bruce Crawford, 2022. "Cost drivers associated with diffuse large B-cell lymphoma (DLBCL) in Japan: A structural equation model (SEM) analysis," PLOS ONE, Public Library of Science, vol. 17(5), pages 1-16, May.
    • Handle: RePEc:plo:pone00:0269169
    DOI: 10.1371/journal.pone.0269169
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269169
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0269169&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0269169?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rosseel, Yves, 2012. "lavaan: An R Package for Structural Equation Modeling," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 48(i02).
    2. P. Bentler, 1983. "Some contributions to efficient statistics in structural models: Specification and estimation of moment structures," Psychometrika, Springer;The Psychometric Society, vol. 48(4), pages 493-517, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sonia Nawrocka & Hans De Witte & Margherita Pasini & Margherita Brondino, 2023. "A Person-Centered Approach to Job Insecurity: Is There a Reciprocal Relationship between the Quantitative and Qualitative Dimensions of Job Insecurity?," IJERPH, MDPI, vol. 20(7), pages 1-27, March.
    2. Md. Mominur Rahman & Bilkis Akhter, 2021. "The impact of investment in human capital on bank performance: evidence from Bangladesh," Future Business Journal, Springer, vol. 7(1), pages 1-13, December.
    3. Masashi Soga & Kevin J. Gaston & Yuichi Yamaura & Kiyo Kurisu & Keisuke Hanaki, 2016. "Both Direct and Vicarious Experiences of Nature Affect Children’s Willingness to Conserve Biodiversity," IJERPH, MDPI, vol. 13(6), pages 1-12, May.
    4. César Merino-Soto & Gina Chávez-Ventura & Verónica López-Fernández & Guillermo M. Chans & Filiberto Toledano-Toledano, 2022. "Learning Self-Regulation Questionnaire (SRQ-L): Psychometric and Measurement Invariance Evidence in Peruvian Undergraduate Students," Sustainability, MDPI, vol. 14(18), pages 1-17, September.
    5. FeCheng Ma & Farhan Khan & Kashif Ullah Khan & Si XiangYun, 2021. "Investigating the Impact of Information Technology, Absorptive Capacity, and Dynamic Capabilities on Firm Performance: An Empirical Study," SAGE Open, , vol. 11(4), pages 21582440211, November.
    6. Nathaniel Oliver Iotti & Damiano Menin & Tomas Jungert, 2022. "Early Adolescents’ Motivations to Defend Victims of Cyberbullying," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    7. AJ Golio, 2024. "Whose Neighborhood Now? Gentrification and Community Life in Low-Income Urban Neighborhoods," Working Papers 24-29, Center for Economic Studies, U.S. Census Bureau.
    8. Peter Tavel & Bibiana Jozefiakova & Peter Telicak & Jana Furstova & Michal Puza & Natalia Kascakova, 2022. "Psychometric Analysis of the Shortened Version of the Spiritual Well-Being Scale on the Slovak Population (SWBS-Sk)," IJERPH, MDPI, vol. 19(1), pages 1-12, January.
    9. Allen, Jaime & Eboli, Laura & Forciniti, Carmen & Mazzulla, Gabriella & Ortúzar, Juan de Dios, 2019. "The role of critical incidents and involvement in transit satisfaction and loyalty," Transport Policy, Elsevier, vol. 75(C), pages 57-69.
    10. Katharina Groskurth & Constanze Beierlein & Désirée Nießen & Anna Baumert & Beatrice Rammstedt & Clemens M Lechner, 2023. "An English-Language adaptation and validation of the Justice Sensitivity Short Scales–8 (JSS-8)," PLOS ONE, Public Library of Science, vol. 18(11), pages 1-22, November.
    11. Christoph Dworschak, 2024. "Bias mitigation in empirical peace and conflict studies: A short primer on posttreatment variables," Journal of Peace Research, Peace Research Institute Oslo, vol. 61(3), pages 462-476, May.
    12. Andreea-Ionela Puiu & Anca Monica Ardeleanu & Camelia Cojocaru & Anca Bratu, 2021. "Exploring the Effect of Status Quo, Innovativeness, and Involvement Tendencies on Luxury Fashion Innovations: The Mediation Role of Status Consumption," Mathematics, MDPI, vol. 9(9), pages 1-18, May.
    13. Slupphaug, KJell & Mehmetoglu, Mehmet & Mittner, Matthias, 2024. "modsem: An R package for estimating latent interactions and quadratic effects," OSF Preprints h3rpw, Center for Open Science.
    14. Andres Trujillo-Barrera & Joost M. E. Pennings & Dianne Hofenk, 2016. "Understanding producers' motives for adopting sustainable practices: the role of expected rewards, risk perception and risk tolerance," European Review of Agricultural Economics, Oxford University Press and the European Agricultural and Applied Economics Publications Foundation, vol. 43(3), pages 359-382.
    15. Daria J. Kuss & Lydia Harkin & Eiman Kanjo & Joel Billieux, 2018. "Problematic Smartphone Use: Investigating Contemporary Experiences Using a Convergent Design," IJERPH, MDPI, vol. 15(1), pages 1-16, January.
    16. Allen, Jaime & Muñoz, Juan Carlos & Ortúzar, Juan de Dios, 2019. "On evasion behaviour in public transport: Dissatisfaction or contagion?," Transportation Research Part A: Policy and Practice, Elsevier, vol. 130(C), pages 626-651.
    17. Cloarec, Julien, 2022. "Privacy controls as an information source to reduce data poisoning in artificial intelligence-powered personalization," Journal of Business Research, Elsevier, vol. 152(C), pages 144-153.
    18. Merkle, Edgar C. & Steyvers, Mark & Mellers, Barbara & Tetlock, Philip E., 2017. "A neglected dimension of good forecasting judgment: The questions we choose also matter," International Journal of Forecasting, Elsevier, vol. 33(4), pages 817-832.
    19. Sai-fu Fung & Esther Oi-wah Chow & Chau-kiu Cheung, 2020. "Development and Evaluation of the Psychometric Properties of a Brief Wisdom Development Scale," IJERPH, MDPI, vol. 17(8), pages 1-14, April.
    20. repec:plo:pone00:0205222 is not listed on IDEAS
    21. Goran Calic & Moren Lévesque & Anton Shevchenko, 2024. "On why women-owned businesses take more time to secure microloans," Small Business Economics, Springer, vol. 63(3), pages 917-938, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0269169. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.