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Replicating prediction algorithms for hospitalization and corticosteroid use in patients with inflammatory bowel disease

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  • Ryan W Gan
  • Diana Sun
  • Amanda R Tatro
  • Shirley Cohen-Mekelburg
  • Wyndy L Wiitala
  • Ji Zhu
  • Akbar K Waljee

Abstract

Introduction: Previous work had shown that machine learning models can predict inflammatory bowel disease (IBD)-related hospitalizations and outpatient corticosteroid use based on patient demographic and laboratory data in a cohort of United States Veterans. This study aimed to replicate this modeling framework in a nationally representative cohort. Methods: A retrospective cohort design using Optum Electronic Health Records (EHR) were used to identify IBD patients, with at least 12 months of follow-up between 2007 and 2018. IBD flare was defined as an inpatient/emergency visit with a diagnosis of IBD or an outpatient corticosteroid prescription for IBD. Predictors included demographic and laboratory data. Logistic regression and random forest (RF) models were used to predict IBD flare within 6 months of each visit. A 70% training and 30% validation approach was used. Results: A total of 95,878 patients across 780,559 visits were identified. Of these, 22,245 (23.2%) patients had at least one IBD flare. Patients were predominantly White (87.7%) and female (57.1%), with a mean age of 48.0 years. The logistic regression model had an area under the receiver operating curve (AuROC) of 0.66 (95% CI: 0.65−0.66), sensitivity of 0.69 (95% CI: 0.68−0.70), and specificity of 0.74 (95% CI: 0.73−0.74) in the validation cohort. The RF model had an AuROC of 0.80 (95% CI: 0.80−0.81), sensitivity of 0.74 (95% CI: 0.73−0.74), and specificity of 0.72 (95% CI: 0.72−0.72) in the validation cohort. Important predictors of IBD flare in the RF model were the number of previous flares, age, potassium, and white blood cell count. Conclusion: The machine learning modeling framework was replicated and results showed a similar predictive accuracy in a nationally representative cohort of IBD patients. This modeling framework could be embedded in routine practice as a tool to distinguish high-risk patients for disease activity.

Suggested Citation

  • Ryan W Gan & Diana Sun & Amanda R Tatro & Shirley Cohen-Mekelburg & Wyndy L Wiitala & Ji Zhu & Akbar K Waljee, 2021. "Replicating prediction algorithms for hospitalization and corticosteroid use in patients with inflammatory bowel disease," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0257520
    DOI: 10.1371/journal.pone.0257520
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