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Phenotypic characterization of Gardnerella vaginalis subgroups suggests differences in their virulence potential

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  • Migle Janulaitiene
  • Vilmantas Gegzna
  • Lina Baranauskiene
  • Aistė Bulavaitė
  • Martynas Simanavicius
  • Milda Pleckaityte

Abstract

The well-known genotypic and phenotypic diversity of G. vaginalis resulted in its classification into at least four subgroups (clades) with diverse genomic properties. To evaluate the virulence potential of G. vaginalis subgroups, we analyzed the virulence-related phenotypic characteristics of 14 isolates of clade 1, 12 isolates of clade 2, 8 isolates of clade 4 assessing their in vitro ability to grow as a biofilm, produce the toxin vaginolysin, and express sialidase activity. Significant differences in VLY production were found (p = 0.023), but further analysis of clade pairs did not confirm this finding. The amount of biofim did not differ significantly among the clades. Analysis of sialidase activity indicated statistically significant differences among the clades (p

Suggested Citation

  • Migle Janulaitiene & Vilmantas Gegzna & Lina Baranauskiene & Aistė Bulavaitė & Martynas Simanavicius & Milda Pleckaityte, 2018. "Phenotypic characterization of Gardnerella vaginalis subgroups suggests differences in their virulence potential," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-20, July.
    • Handle: RePEc:plo:pone00:0200625
    DOI: 10.1371/journal.pone.0200625
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