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Meta-Analysis of a Complex Network of Non-Pharmacological Interventions: The Example of Femoral Neck Fracture

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  • Jonathan Mosseri
  • Ludovic Trinquart
  • Rémy Nizard
  • Philippe Ravaud

Abstract

Background: Surgical interventions raise specific methodological issues in network meta-analysis (NMA). They are usually multi-component interventions resulting in complex networks of randomized controlled trials (RCTs), with multiple groups and sparse connections. Purpose: To illustrate the applicability of the NMA in a complex network of surgical interventions and to prioritize the available interventions according to a clinically relevant outcome. Methods: We considered RCTs of treatments for femoral neck fracture in adults. We searched CENTRAL, MEDLINE, EMBASE and ClinicalTrials.gov up to November 2015. Two reviewers independently selected trials, extracted data and used the Cochrane Collaboration’s tool for assessing the risk of bias. A group of orthopedic surgeons grouped similar but not identical interventions under the same node. We synthesized the network using a Bayesian network meta-analysis model. We derived posterior odds ratios (ORs) and 95% credible intervals (95% CrIs) for all possible pairwise comparisons. The primary outcome was all-cause revision surgery. Results: Data from 27 trials were combined, for 4,186 participants (72% women, mean age 80 years, 95% displaced fractures). The median follow-up was 2 years. With hemiarthroplasty (HA) and total hip arthroplasty (THA) as a comparison, risk of surgical revision was significantly higher with the treatments unthreaded cervical osteosynthesis (OR 8.0 [95% CrI 3.6–15.5] and 5.9 [2.4–12.0], respectively), screw (9.4 [6.0–16.5] and 6.7 [3.9–13.6]) and plate (12.5 [5.8–23.8] and 7.8 [3.8–19.4]). Conclusions: In older women with displaced femoral neck fractures, arthroplasty (HA and THA) is the most effective treatment in terms of risk of revision surgery. Systematic Review Registration: PROSPERO no. CRD42013004218. Level of Evidence: Network Meta-Analysis, Level 1.

Suggested Citation

  • Jonathan Mosseri & Ludovic Trinquart & Rémy Nizard & Philippe Ravaud, 2016. "Meta-Analysis of a Complex Network of Non-Pharmacological Interventions: The Example of Femoral Neck Fracture," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-16, January.
    • Handle: RePEc:plo:pone00:0146336
    DOI: 10.1371/journal.pone.0146336
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    References listed on IDEAS

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    1. Sofia Dias & Nicky J. Welton & Alex J. Sutton & A. E. Ades, 2013. "Evidence Synthesis for Decision Making 5," Medical Decision Making, , vol. 33(5), pages 657-670, July.
    2. Sofia Dias & Nicky J. Welton & Alex J. Sutton & Deborah M. Caldwell & Guobing Lu & A. E. Ades, 2013. "Evidence Synthesis for Decision Making 4," Medical Decision Making, , vol. 33(5), pages 641-656, July.
    3. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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    1. Ferrán Catalá-López & Brian Hutton & Amparo Núñez-Beltrán & Matthew J Page & Manuel Ridao & Diego Macías Saint-Gerons & Miguel A Catalá & Rafael Tabarés-Seisdedos & David Moher, 2017. "The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review with network meta-analyses of randomised trials," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-31, July.

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