IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0093024.html
   My bibliography  Save this article

Predictive Value of Imaging Markers at Multiple Sclerosis Disease Onset Based on Gadolinium- and USPIO-Enhanced MRI and Machine Learning

Author

Listed:
  • Alessandro Crimi
  • Olivier Commowick
  • Adil Maarouf
  • Jean-Christophe Ferré
  • Elise Bannier
  • Ayman Tourbah
  • Isabelle Berry
  • Jean-Philippe Ranjeva
  • Gilles Edan
  • Christian Barillot

Abstract

Objectives: A novel characterization of Clinically Isolated Syndrome (CIS) patients according to lesion patterns is proposed. More specifically, patients are classified according to the nature of inflammatory lesions patterns. It is expected that this characterization can infer new prospective figures from the earliest imaging signs of Multiple Sclerosis (MS), since it can provide a classification of different types of lesions across patients. Methods: The method is based on a two-tiered classification. Initially, the spatio-temporal lesion patterns are classified. The discovered lesion patterns are then used to characterize groups of patients. The patient groups are validated using statistical measures and by correlations at 24-month follow-up with hypointense lesion loads. Results: The methodology identified 3 statistically significantly different clusters of lesion patterns showing p-values smaller than 0.01. Moreover, these patterns defined at baseline correlated with chronic hypointense lesion volumes by follow-up with an score of . Conclusions: The proposed methodology is capable of identifying three major different lesion patterns that are heterogeneously present in patients, allowing a patient classification using only two MRI scans. This finding may lead to more accurate prognosis and thus to more suitable treatments at early stage of MS.

Suggested Citation

  • Alessandro Crimi & Olivier Commowick & Adil Maarouf & Jean-Christophe Ferré & Elise Bannier & Ayman Tourbah & Isabelle Berry & Jean-Philippe Ranjeva & Gilles Edan & Christian Barillot, 2014. "Predictive Value of Imaging Markers at Multiple Sclerosis Disease Onset Based on Gadolinium- and USPIO-Enhanced MRI and Machine Learning," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0093024
    DOI: 10.1371/journal.pone.0093024
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093024
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093024&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0093024?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Robert Tibshirani & Guenther Walther & Trevor Hastie, 2001. "Estimating the number of clusters in a data set via the gap statistic," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(2), pages 411-423.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Thiemo Fetzer & Samuel Marden, 2017. "Take What You Can: Property Rights, Contestability and Conflict," Economic Journal, Royal Economic Society, vol. 0(601), pages 757-783, May.
    2. Daniel Agness & Travis Baseler & Sylvain Chassang & Pascaline Dupas & Erik Snowberg, 2022. "Valuing the Time of the Self-Employed," Working Papers 2022-2, Princeton University. Economics Department..
    3. Khanh Duong, 2024. "Is meritocracy just? New evidence from Boolean analysis and Machine learning," Journal of Computational Social Science, Springer, vol. 7(2), pages 1795-1821, October.
    4. Batool, Fatima & Hennig, Christian, 2021. "Clustering with the Average Silhouette Width," Computational Statistics & Data Analysis, Elsevier, vol. 158(C).
    5. Nicoleta Serban & Huijing Jiang, 2012. "Multilevel Functional Clustering Analysis," Biometrics, The International Biometric Society, vol. 68(3), pages 805-814, September.
    6. Orietta Nicolis & Jean Paul Maidana & Fabian Contreras & Danilo Leal, 2024. "Analyzing the Impact of COVID-19 on Economic Sustainability: A Clustering Approach," Sustainability, MDPI, vol. 16(4), pages 1-30, February.
    7. Li, Pai-Ling & Chiou, Jeng-Min, 2011. "Identifying cluster number for subspace projected functional data clustering," Computational Statistics & Data Analysis, Elsevier, vol. 55(6), pages 2090-2103, June.
    8. Yaeji Lim & Hee-Seok Oh & Ying Kuen Cheung, 2019. "Multiscale Clustering for Functional Data," Journal of Classification, Springer;The Classification Society, vol. 36(2), pages 368-391, July.
    9. Forzani, Liliana & Gieco, Antonella & Tolmasky, Carlos, 2017. "Likelihood ratio test for partial sphericity in high and ultra-high dimensions," Journal of Multivariate Analysis, Elsevier, vol. 159(C), pages 18-38.
    10. Yujia Li & Xiangrui Zeng & Chien‐Wei Lin & George C. Tseng, 2022. "Simultaneous estimation of cluster number and feature sparsity in high‐dimensional cluster analysis," Biometrics, The International Biometric Society, vol. 78(2), pages 574-585, June.
    11. Vojtech Blazek & Michal Petruzela & Tomas Vantuch & Zdenek Slanina & Stanislav Mišák & Wojciech Walendziuk, 2020. "The Estimation of the Influence of Household Appliances on the Power Quality in a Microgrid System," Energies, MDPI, vol. 13(17), pages 1-21, August.
    12. Andrew Clark & Alexander Mihailov & Michael Zargham, 2024. "Complex Systems Modeling of Community Inclusion Currencies," Computational Economics, Springer;Society for Computational Economics, vol. 64(2), pages 1259-1294, August.
    13. Nicoleta Serban, 2008. "Estimating and clustering curves in the presence of heteroscedastic errors," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 20(7), pages 553-571.
    14. Caruso, Germán & Scartascini, Carlos & Tommasi, Mariano, 2015. "Are we all playing the same game? The economic effects of constitutions depend on the degree of institutionalization," European Journal of Political Economy, Elsevier, vol. 38(C), pages 212-228.
    15. Mehmet Çağlar & Cem Gürler, 2022. "Sustainable Development Goals: A cluster analysis of worldwide countries," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 24(6), pages 8593-8624, June.
    16. Elizabeth Tipton & Robert B. Olsen, "undated". "Enhancing the Generalizability of Impact Studies in Education," Mathematica Policy Research Reports 35d5625333dc480aba9765b3b, Mathematica Policy Research.
    17. Cyril Atkinson-Clement & Eléonore Pigalle, 2021. "What can we learn from Covid-19 pandemic’s impact on human behaviour? The case of France’s lockdown," Palgrave Communications, Palgrave Macmillan, vol. 8(1), pages 1-12, December.
    18. Jelle R Dalenberg & Luca Nanetti & Remco J Renken & René A de Wijk & Gert J ter Horst, 2014. "Dealing with Consumer Differences in Liking during Repeated Exposure to Food; Typical Dynamics in Rating Behavior," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    19. Daniel Lewis & Davide Melcangi & Laura Pilossoph, 2019. "Latent Heterogeneity in the Marginal Propensity to Consume," 2019 Meeting Papers 519, Society for Economic Dynamics.
    20. Chun-Xia Zhang & Jiang-She Zhang & Sang-Woon Kim, 2016. "PBoostGA: pseudo-boosting genetic algorithm for variable ranking and selection," Computational Statistics, Springer, vol. 31(4), pages 1237-1262, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0093024. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.