IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0061456.html
   My bibliography  Save this article

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

Author

Listed:
  • Yi Gong
  • Leida Zhang
  • Ping Bie
  • Huaizhi Wang

Abstract

Background: Gallstones (GS) is the major manifestation of gallbladder disease, and is the most common risk factor for gallbladder cancer (GBC). Previous studies investigating the association between ApoB-100 gene polymorphisms and the risks of GS and GBC have yielded conflicting results. Therefore, we performed a meta-analysis to clarify the effects of ApoB-100 gene polymorphisms on the risks of GS and GBC. Methods: A computerized literature search was conducted to identify the relevant studies from PubMed and Embase. Fixed or random effects model was selected based on heterogeneity test. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test. Results: A total of 10, 3, and 3 studies were included in the analyses of the association between ApoB-100 XbaI, EcoRI, or insertion/deletion (ID) polymorphisms and the GS risks, respectively, while 3 studies were included in the analysis for the association between XbaI polymorphism and GBC risk. The combined results showed a significant association in Chinese (X+ vs. X−, OR = 2.37, 95%CI 1.52–3.70; X+X+/X+X- vs. X+X+, OR = 2.47, 95%CI 1.55–3.92), but not in Indians or Caucasians. Null association was observed between EcoRI or ID polymorphisms and GS risks. With regard to the association between XbaI polymorphism and GBC risk, a significant association was detected when GBC patients were compared with healthy persons and when GBC patients were compared with GS patients. A significant association was still detected when GBC patients (with GS) were compared with the GS patients (X+X+ vs. X-X−, OR = 0.33, 95%CI 0.12–0.90). Conclusion: The results of this meta-analysis suggest that the ApoB-100 X+ allele might be associated with increased risk of GS in Chinese but not in other populations, while the ApoB-100 X+X+ genotype might be associated with reduced risk of GBC. Further studies with larger sample sizes are needed to confirm these results.

Suggested Citation

  • Yi Gong & Leida Zhang & Ping Bie & Huaizhi Wang, 2013. "Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.
    • Handle: RePEc:plo:pone00:0061456
    DOI: 10.1371/journal.pone.0061456
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061456
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061456&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0061456?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Roger M. Harbord & Ross J. Harris & Jonathan A. C. Sterne, 2009. "Updated tests for small-study effects in meta-analyses," Stata Journal, StataCorp LLC, vol. 9(2), pages 197-210, June.
    2. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    3. Jin-Wei Cheng & Shi-Wei Cheng & Xiao-Ye Ma & Ji-Ping Cai & You Li & Guo-Cai Lu & Rui-Li Wei, 2012. "Myocilin Polymorphisms and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    4. Tao Zeng & Fang-Fang Guo & Cui-Li Zhang & Fu-Yong Song & Xiu-Lan Zhao & Ke-Qin Xie, 2013. "Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    5. Aurelio Tobias, 1999. "Assessing the influence of a single study in the meta-anyalysis estimate," Stata Technical Bulletin, StataCorp LLC, vol. 8(47).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nick Freemantle, 2008. "Biostatistical aspects for the use of evidence based medicine in health technology assessment," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 9(1), pages 31-43, November.
    2. Meng-Bo Hu & Sheng-Hua Liu & Hao-Wen Jiang & Pei-De Bai & Qiang Ding, 2014. "Obesity Affects the Biopsy-Mediated Detection of Prostate Cancer, Particularly High-Grade Prostate Cancer: A Dose-Response Meta-Analysis of 29,464 Patients," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-10, September.
    3. Fanjie Meng & Xiangpo Pan & Wenzhen Tong, 2018. "Rifampicin versus streptomycin for brucellosis treatment in humans: A meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-12, February.
    4. Meiyun Wang & Xiubo Jiang & Wenlong Wu & Dongfeng Zhang, 2013. "Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-9, March.
    5. Allison Milner & Andrew Page & Anthony D LaMontagne, 2013. "Long-Term Unemployment and Suicide: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-6, January.
    6. Jennifer S. Wong & Chelsey Lee & Natalie Beck, 2024. "The effects of aftercare/resettlement services on crime and violence in children and youth: A systematic review," Campbell Systematic Reviews, John Wiley & Sons, vol. 20(2), June.
    7. Doris S M Chan & Rosa Lau & Dagfinn Aune & Rui Vieira & Darren C Greenwood & Ellen Kampman & Teresa Norat, 2011. "Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-11, June.
    8. Shan Liu & Qing Li & Ying Zhang & Qiushuang Li & Baodong Ye & Dijiong Wu & Li Wu & Hanti Lu & Conghua Ji, 2016. "Association of Human Leukocyte Antigen DRB1*15 and DRB1*15:01 Polymorphisms with Response to Immunosuppressive Therapy in Patients with Aplastic Anemia: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-15, September.
    9. Bijing Mao & Yafei Li & Zhimin Zhang & Chuan Chen & Yuanyuan Chen & Chenchen Ding & Lin Lei & Jian Li & Mei Jiang & Dong Wang & Ge Wang, 2015. "One-Carbon Metabolic Factors and Risk of Renal Cell Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-10, October.
    10. Yuan Yuan Hu & Hua Yuan & Guang Bing Jiang & Ning Chen & Li Wen & Wei Dong Leng & Xian Tao Zeng & Yu Ming Niu, 2012. "Associations between XPD Asp312Asn Polymorphism and Risk of Head and Neck Cancer: A Meta-Analysis Based on 7,122 Subjects," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-6, April.
    11. Tseday Jemaneh Mekasha & Finn Tarp, 2013. "Aid and Growth: What Meta-Analysis Reveals," Journal of Development Studies, Taylor & Francis Journals, vol. 49(4), pages 564-583, April.
    12. Qian Chen & Rongliang Shi & Weiyan Liu & Daowen Jiang, 2013. "Assessing Interactions between the Association of Common Genetic Variant at 1p11 (rs11249433) and Hormone Receptor Status with Breast Cancer Risk," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.
    13. Ngamaba, Kayonda Hubert & Armitage, Christopher & Panagioti, Maria & Hodkinson, Alexander, 2020. "How closely related are financial satisfaction and subjective well-being? Systematic review and meta-analysis," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 85(C).
    14. Libing Wang & Fan Yin & Xia Xu & Xiaoxia Hu & Dongbao Zhao, 2012. "X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-6, April.
    15. Qiang Cai & Jian Wu & Qu Cai & Er-Zhen Chen & Zhao-Yan Jiang, 2015. "Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    16. Li-Yuan Liu & Meng Wang & Zhong-Bing Ma & Li-Xiang Yu & Qiang Zhang & De-Zong Gao & Fei Wang & Zhi-Gang Yu, 2013. "The Role of Adiponectin in Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    17. Haolin Wang & Wendy Y. Huang & Yanan Zhao, 2022. "Efficacy of Exercise on Muscle Function and Physical Performance in Older Adults with Sarcopenia: An Updated Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(13), pages 1-16, July.
    18. Marta Liliana Musskopf & Amanda Finger Stadler & Ulf ME Wikesjö & Cristiano Susin, 2022. "The minipig intraoral dental implant model: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    19. Qurat-ul-Ann, Abre-Rehmat & Mirza, Faisal Mehmood, 2020. "Meta-analysis of empirical evidence on energy poverty: The case of developing economies," Energy Policy, Elsevier, vol. 141(C).
    20. Lin Zhao & Aihua Gu & Guixiang Ji & Peng Zou & Peng Zhao & Ailin Lu, 2012. "The Association between ATM IVS 22-77 T>C and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0061456. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.