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Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis

Author

Listed:
  • Qiang Cai
  • Jian Wu
  • Qu Cai
  • Er-Zhen Chen
  • Zhao-Yan Jiang

Abstract

Background: The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk. Methods: Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2). Results: A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03–1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11–1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12–1.71, P = 0.003, I2 = 93%). Conclusions: Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.

Suggested Citation

  • Qiang Cai & Jian Wu & Qu Cai & Er-Zhen Chen & Zhao-Yan Jiang, 2015. "Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    • Handle: RePEc:plo:pone00:0117173
    DOI: 10.1371/journal.pone.0117173
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    References listed on IDEAS

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    1. Hua Zhao & Kui-Jie Liu & Zhen-Dong Lei & San-Lin Lei & Yong-Quan Tian, 2014. "Meta-Analysis of the Aldehyde Dehydrogenases-2 (ALDH2) Glu487Lys Polymorphism and Colorectal Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    2. He-Ling Wang & Ping-Yi Zhou & Peng Liu & Yu Zhang, 2014. "ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    3. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
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