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Prevalence of mortality among mechanically ventilated patients in the intensive care units of Ethiopian hospitals and the associated factors: A systematic review and meta-analysis

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Listed:
  • Temesgen Ayenew
  • Mihretie Gedfew
  • Mamaru Getie Fetene
  • Belayneh Shetie Workneh
  • Animut Takele Telayneh
  • Afework Edmealem
  • Bekele Getenet Tiruneh
  • Guadie Tewabe Yinges
  • Addisu Getie
  • Mengistu Abebe Meselu

Abstract

Background: In the intensive care unit (ICU), mechanical ventilation (MV) is a typical way of respiratory support. The severity of the illness raises the likelihood of death in patients who require MV. Several studies have been done in Ethiopia; however, the mortality rate differs among them. The objective of this systematic review and meta-analysis is to provide a pooled prevalence of mortality and associated factors among ICU-admitted patients receiving MV in Ethiopian hospitals. Methods: We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 criteria to conduct a comprehensive systematic review and meta-analysis in this study. We searched PubMed/Medline, SCOPUS, Embase, Hinari, and Web of Science and found 22 articles that met our inclusion criteria. We used a random-effects model. To identify heterogeneity within the included studies, meta-regression and subgroup analysis were used. We employed Egger’s regression test and funnel plots for assessing publication bias. STATA version 17.0 software was used for all statistical analyses. Results: In this systematic review and meta-analysis, the pooled prevalence of mortality among 7507 ICU-admitted patients from 22 articles, who received MV was estimated to be 54.74% [95% CI = 47.93, 61.55]. In the subgroup analysis by region, the Southern Nations, Nationalities, and Peoples (SNNP) subgroup (64.28%, 95% CI = 51.19, 77.37) had the highest prevalence. Patients with COVID-19 have the highest mortality rate (75.80%, 95% CI = 51.10, 100.00). Sepsis (OR = 6.85, 95%CI = 3.24, 14.46), Glasgow Coma Scale (GCS) score

Suggested Citation

  • Temesgen Ayenew & Mihretie Gedfew & Mamaru Getie Fetene & Belayneh Shetie Workneh & Animut Takele Telayneh & Afework Edmealem & Bekele Getenet Tiruneh & Guadie Tewabe Yinges & Addisu Getie & Mengistu , 2024. "Prevalence of mortality among mechanically ventilated patients in the intensive care units of Ethiopian hospitals and the associated factors: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(7), pages 1-18, July.
    • Handle: RePEc:plo:pone00:0306277
    DOI: 10.1371/journal.pone.0306277
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    References listed on IDEAS

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    1. Kristian Thorlund & Georgina Imberger & Bradley C Johnston & Michael Walsh & Tahany Awad & Lehana Thabane & Christian Gluud & P J Devereaux & Jørn Wetterslev, 2012. "Evolution of Heterogeneity (I2) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
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