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Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat


  • Jennifer MacKellar
  • Samuel W Cushman
  • Vipul Periwal


Background: In mammals, calories ingested in excess of those used are stored primarily as fat in adipose tissue; consistent ingestion of excess calories requires an enlargement of the adipose tissue mass. Thus, a dysfunction in adipose tissue growth may be a key factor in insulin resistance due to imbalanced fat storage and disrupted insulin action. Adipose tissue growth requires the recruitment and then the development of adipose precursor cells, but little is known about these processes in vivo. Methodology: In this study, adipose cell-size probability distributions were measured in two Zucker fa/fa rats over a period of 151 and 163 days, from four weeks of age, using micro-biopsies to obtain subcutaneous (inguinal) fat tissue from the animals. These longitudinal probability distributions were analyzed to assess the probability of periodic phenomena. Conclusions: Adipose tissue growth in this strain of rat exhibits a striking temporal periodicity of approximately days. A simple model is proposed for the periodicity, with PPAR signaling driven by a deficit in lipid uptake capacity leading to the periodic recruitment of new adipocytes. This model predicts that the observed period will be diet-dependent.

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  • Jennifer MacKellar & Samuel W Cushman & Vipul Periwal, 2010. "Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat," PLOS ONE, Public Library of Science, vol. 5(1), pages 1-9, January.
  • Handle: RePEc:plo:pone00:0008197
    DOI: 10.1371/journal.pone.0008197

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    References listed on IDEAS

    1. Kirsty L. Spalding & Erik Arner & Pål O. Westermark & Samuel Bernard & Bruce A. Buchholz & Olaf Bergmann & Lennart Blomqvist & Johan Hoffstedt & Erik Näslund & Tom Britton & Hernan Concha & Moustapha , 2008. "Dynamics of fat cell turnover in humans," Nature, Nature, vol. 453(7196), pages 783-787, June.
    2. Gregory S. Barsh & I. Sadaf Farooqi & Stephen O'Rahilly, 2000. "Genetics of body-weight regulation," Nature, Nature, vol. 404(6778), pages 644-651, April.
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