IDEAS home Printed from https://ideas.repec.org/a/plo/pntd00/0008329.html

The organization, weaknesses, and challenges of the control of thalidomide in Brazil: A review

Author

Listed:
  • Soraya Machado de Jesus
  • Rafael Santos Santana
  • Silvana Nair Leite

Abstract

The drug thalidomide has resurged in the world market under restrictive conditions for marketing and use. In Brazil, there are still cases of pregnant women using thalidomide even after the implementation of laws that regulate the control of use (Law No. 10.651/2003 and Collegiate Board Resolution No. 11/2011). The objective of this study was to discuss the control of thalidomide use in Brazil, based on a scoping review of the scientific literature, documents, and data from the Ministry of Health. A total of 51 studies and documents related to the following subthemes were selected: (1) organization of access and use of thalidomide in the health system; (2) epidemiological and population characteristics of people affected by leprosy; and (3) occurrence of pregnancy and cases of embryopathy with the use of thalidomide. The results showed that Brazil has no unified information database about thalidomide patients. Furthermore, there is inconsistency in the accreditation of public health centers that dispense this medicine, in a country that has a high consumption of thalidomide in the Unified Health System. A large part of this amount of dispensed medicine is intended for the treatment of erythema nodosum leprosum, mainly in the North, Northeast, and Central-West regions of the country, which are endemic for leprosy. This disease is the only one among the clinical indications of the medicine approved in Brazil that does not have a Clinical Protocol and Therapeutic Guidelines. The control of thalidomide use in Brazil presents historical regulatory failures. These are currently linked to the organization and structure of primary healthcare in the country, as well as to the lack of leadership of the Ministry of Health and National Health Surveillance Agency when it comes to managing the process of control of this use.

Suggested Citation

  • Soraya Machado de Jesus & Rafael Santos Santana & Silvana Nair Leite, 2020. "The organization, weaknesses, and challenges of the control of thalidomide in Brazil: A review," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(8), pages 1-24, August.
    • Handle: RePEc:plo:pntd00:0008329
    DOI: 10.1371/journal.pntd.0008329
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008329
    Download Restriction: no
    File URL: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008329&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pntd.0008329?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Nancy A. Brandenburg & Robert Bwire & John Freeman & Florence Houn & Paul Sheehan & Jerome B. Zeldis, 2017. "Effectiveness of Risk Evaluation and Mitigation Strategies (REMS) for Lenalidomide and Thalidomide: Patient Comprehension and Knowledge Retention," Drug Safety, Springer, vol. 40(4), pages 333-341, April.
    2. Rafael Santos Santana & Evandro de Oliveira Lupatini & Fernando Zanghelini & Ricardo de March Ronsoni & Norberto Rech & Silvana Nair Leite, 2018. "The different clinical guideline standards in Brazil: High cost treatment diseases versus poverty-related diseases," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-12, October.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Zhen-Jie Wu & Yuan Lin & Jun Xiao & Liu-Cheng Wu & Jun-Gang Liu, 2014. "Clinical Significance of Colonoscopy in Patients with Upper Gastrointestinal Polyps and Neoplasms: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-8, March.
    2. Guian Zheng & Yuxin Li & Huishan Huang & Jinghan Wang & Atsushi Hirayama & Jinxiu Lin, 2015. "The Effect of Statin Therapy on Coronary Plaque Composition Using Virtual Histology Intravascular Ultrasound: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-14, July.
    3. Fabio Alexis Rincón Uribe & Cristian Ariel Neira Espejo & Janari da Silva Pedroso, 2022. "The Role of Optimism in Adolescent Mental Health: A Systematic Review," Journal of Happiness Studies, Springer, vol. 23(2), pages 815-845, February.
    4. Yucheon Kim & Songyi Lee, 2023. "A Systematic Review and Meta-Analysis of the Effectiveness of Non-Face-to-Face Coaching," Sustainability, MDPI, vol. 15(12), pages 1-15, June.
    5. Blessing Charuka & Donatus Bapentire Angnuureng & Samuel K. M. Agblorti, 2023. "Contemporary Global Coastal Management Strategies and Coastal Infrastructure and Their Application in Ghana: A Systematic Literature Review," Sustainability, MDPI, vol. 15(17), pages 1-23, August.
    6. İlkay Unay-Gailhard & Mark A. Brennen, 2022. "How digital communications contribute to shaping the career paths of youth: a review study focused on farming as a career option," Agriculture and Human Values, Springer;The Agriculture, Food, & Human Values Society (AFHVS), vol. 39(4), pages 1491-1508, December.
    7. Karen Setty & Ryan Cronk & Shannan George & Darcy Anderson & Għanja O’Flaherty & Jamie Bartram, 2019. "Adapting Translational Research Methods to Water, Sanitation, and Hygiene," IJERPH, MDPI, vol. 16(20), pages 1-31, October.
    8. Mahin Ghafari & Vali Baigi & Zahra Cheraghi & Amin Doosti-Irani, 2016. "The Prevalence of Asymptomatic Bacteriuria in Iranian Pregnant Women: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-10, June.
    9. Elizabeth T Cafiero-Fonseca & Andrew Stawasz & Sydney T Johnson & Reiko Sato & David E Bloom, 2017. "The full benefits of adult pneumococcal vaccination: A systematic review," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-23, October.
    10. Santos Urbina & Sofía Villatoro & Jesús Salinas, 2021. "Self-Regulated Learning and Technology-Enhanced Learning Environments in Higher Education: A Scoping Review," Sustainability, MDPI, vol. 13(13), pages 1-12, June.
    11. Scott, Daniel & Gössling, Stefan, 2022. "A review of research into tourism and climate change - Launching the annals of tourism research curated collection on tourism and climate change," Annals of Tourism Research, Elsevier, vol. 95(C).
    12. Natalia Hernández-Segura & Alba Marcos-Delgado & Arrate Pinto-Carral & Tania Fernández-Villa & Antonio J. Molina, 2022. "Health-Related Quality of Life (HRQOL) Instruments and Mobility: A Systematic Review," IJERPH, MDPI, vol. 19(24), pages 1-23, December.
    13. Oded Berger-Tal & Alison L Greggor & Biljana Macura & Carrie Ann Adams & Arden Blumenthal & Amos Bouskila & Ulrika Candolin & Carolina Doran & Esteban Fernández-Juricic & Kiyoko M Gotanda & Catherine , 2019. "Systematic reviews and maps as tools for applying behavioral ecology to management and policy," Behavioral Ecology, International Society for Behavioral Ecology, vol. 30(1), pages 1-8.
    14. Uthman Albakri & Elizabeth Drotos & Ree Meertens, 2021. "Sleep Health Promotion Interventions and Their Effectiveness: An Umbrella Review," IJERPH, MDPI, vol. 18(11), pages 1-39, May.
    15. Jingyun Yang & Joseph Gyekis, 2012. "COOPER, H.M. (2009). Research Synthesis and Meta-analysis: A Step-by-Step Approach (Applied Social Research Methods)," Psychometrika, Springer;The Psychometric Society, vol. 77(4), pages 849-850, October.
    16. Sebastian Kohl & Jan Schoenfelder & Andreas Fügener & Jens O. Brunner, 2019. "The use of Data Envelopment Analysis (DEA) in healthcare with a focus on hospitals," Health Care Management Science, Springer, vol. 22(2), pages 245-286, June.
    17. Nadine Desrochers & Adèle Paul‐Hus & Jen Pecoskie, 2017. "Five decades of gratitude: A meta‐synthesis of acknowledgments research," Journal of the Association for Information Science & Technology, Association for Information Science & Technology, vol. 68(12), pages 2821-2833, December.
    18. Maryono, Maryono & Killoes, Aditya Marendra & Adhikari, Rajendra & Abdul Aziz, Ammar, 2024. "Agriculture development through multi-stakeholder partnerships in developing countries: A systematic literature review," Agricultural Systems, Elsevier, vol. 213(C).
    19. Eftychia Ntostoglou & Dilip Khatiwada & Viktoria Martin, 2021. "The Potential Contribution of Decentralized Anaerobic Digestion towards Urban Biowaste Recovery Systems: A Scoping Review," Sustainability, MDPI, vol. 13(23), pages 1-21, December.
    20. Alene Sze Jing Yong & Yi Heng Lim & Mark Wing Loong Cheong & Ednin Hamzah & Siew Li Teoh, 2022. "Willingness-to-pay for cancer treatment and outcome: a systematic review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(6), pages 1037-1057, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pntd00:0008329. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosntds (email available below). General contact details of provider: https://journals.plos.org/plosntds/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.