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A self-powered intracardiac pacemaker in swine model

Author

Listed:
  • Zhuo Liu

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beihang University)

  • Yiran Hu

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    Beijing Tiantan Hospital, Capital Medical University)

  • Xuecheng Qu

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ying Liu

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Sijing Cheng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhengmin Zhang

    (Hangzhou Dianzi University)

  • Yizhu Shan

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences)

  • Ruizeng Luo

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences)

  • Sixian Weng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Hui Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Hongxia Niu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Min Gu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yan Yao

    (Capital Medical University)

  • Bojing Shi

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beihang University)

  • Ningning Wang

    (Hangzhou Dianzi University)

  • Wei Hua

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhou Li

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhong Lin Wang

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Georgia Institute of Technology)

Abstract

Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction for the treatment of arrhythmia in large animal models. We show that the capsule-shaped device (1.75 g, 1.52 cc) can be integrated with a delivery catheter for implanting in the right ventricle of a swine through the intravenous route, which effectively converts cardiac motion energy to electricity and maintains endocardial pacing function during the three-week follow-up period. We measure in vivo open circuit voltage and short circuit current of the self-powered intracardiac pacemaker of about 6.0 V and 0.2 μA, respectively. This approach exhibits up-to-date progress in self-powered medical devices and it may overcome the inherent energy shortcomings of implantable pacemakers and other bioelectronic devices for therapy and sensing.

Suggested Citation

  • Zhuo Liu & Yiran Hu & Xuecheng Qu & Ying Liu & Sijing Cheng & Zhengmin Zhang & Yizhu Shan & Ruizeng Luo & Sixian Weng & Hui Li & Hongxia Niu & Min Gu & Yan Yao & Bojing Shi & Ningning Wang & Wei Hua &, 2024. "A self-powered intracardiac pacemaker in swine model," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44510-6
    DOI: 10.1038/s41467-023-44510-6
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    References listed on IDEAS

    as
    1. Guang Yao & Lei Kang & Jun Li & Yin Long & Hao Wei & Carolina A. Ferreira & Justin J. Jeffery & Yuan Lin & Weibo Cai & Xudong Wang, 2018. "Effective weight control via an implanted self-powered vagus nerve stimulation device," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Hanjun Ryu & Hyun-moon Park & Moo-Kang Kim & Bosung Kim & Hyoun Seok Myoung & Tae Yun Kim & Hong-Joon Yoon & Sung Soo Kwak & Jihye Kim & Tae Ho Hwang & Eue-Keun Choi & Sang-Woo Kim, 2021. "Self-rechargeable cardiac pacemaker system with triboelectric nanogenerators," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. Han Ouyang & Zhuo Liu & Ning Li & Bojing Shi & Yang Zou & Feng Xie & Ye Ma & Zhe Li & Hu Li & Qiang Zheng & Xuecheng Qu & Yubo Fan & Zhong Lin Wang & Hao Zhang & Zhou Li, 2019. "Symbiotic cardiac pacemaker," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
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