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Emergence of task-related spatiotemporal population dynamics in transplanted neurons

Author

Listed:
  • Harman Ghuman

    (University of California, San Francisco)

  • Kyungsoo Kim

    (University of California, San Francisco)

  • Sapeeda Barati

    (University of California, San Francisco)

  • Karunesh Ganguly

    (University of California, San Francisco
    San Francisco Veterans Affairs Medical Center)

Abstract

Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if transplanted neurons can demonstrate the population level dynamics important for movement control. Here we present a comprehensive approach for long-term single neuron monitoring and manipulation of transplanted embryonic cortical neurons after cortical injury in adult male mice performing a prehension task. The observed patterns of population activity in the transplanted network strongly resembled that of healthy networks. Specifically, the task-related spatiotemporal activity patterns of transplanted neurons could be represented by latent factors that evolve within a low dimensional manifold. We also demonstrate reliable modulation of the transplanted networks using minimally invasive epidural stimulation. Our approach may allow greater insight into how restoration of cell-type specific network dynamics in vivo can restore motor function.

Suggested Citation

  • Harman Ghuman & Kyungsoo Kim & Sapeeda Barati & Karunesh Ganguly, 2023. "Emergence of task-related spatiotemporal population dynamics in transplanted neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43081-w
    DOI: 10.1038/s41467-023-43081-w
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