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Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex

Author

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  • Cong Zheng

    (Chinese Academy of Sciences
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Institute for Brain Research)

  • Qifan Wang

    (Chinese Academy of Sciences
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Institute for Brain Research)

  • He Cui

    (Chinese Academy of Sciences
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Institute for Brain Research)

Abstract

Neural activity in the motor cortex evolves dynamically to prepare and generate movement. Here, we investigate how motor cortical dynamics adapt to dynamic environments and whether these adaptations influence robustness against disruptions. We apply intracortical microstimulation (ICMS) in the motor cortex of monkeys performing delayed center-out reaches to either a static target (static) or a rotating target (moving) that required interception. While ICMS prolongs reaction times (RTs) in the static condition, it does not increase RTs in the moving condition, correlating with faster recovery of neural population activity post-perturbation. Neural dynamics suggests that the moving condition involves ongoing sensorimotor transformations during the delay period, whereas motor planning in the static condition is completed shortly. A neural network model shows that continuous feedback input rapidly corrects perturbation-induced errors in the moving condition. We conclude that continuous sensorimotor transformations enhance the motor cortex’s resilience to perturbations, facilitating timely movement execution.

Suggested Citation

  • Cong Zheng & Qifan Wang & He Cui, 2025. "Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58421-1
    DOI: 10.1038/s41467-025-58421-1
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    1. Takahide Itokazu & Masashi Hasegawa & Rui Kimura & Hironobu Osaki & Urban-Raphael Albrecht & Kazuhiro Sohya & Shubhodeep Chakrabarti & Hideaki Itoh & Tetsufumi Ito & Tatsuo K. Sato & Takashi R. Sato, 2018. "Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    2. Tianwei Wang & Yun Chen & Yiheng Zhang & He Cui, 2024. "Multiplicative joint coding in preparatory activity for reaching sequence in macaque motor cortex," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Valerio Mante & David Sussillo & Krishna V. Shenoy & William T. Newsome, 2013. "Context-dependent computation by recurrent dynamics in prefrontal cortex," Nature, Nature, vol. 503(7474), pages 78-84, November.
    4. Barbara Feulner & Matthew G. Perich & Raeed H. Chowdhury & Lee E. Miller & Juan A. Gallego & Claudia Clopath, 2022. "Small, correlated changes in synaptic connectivity may facilitate rapid motor learning," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Daniel L. Kimmel & Gamaleldin F. Elsayed & John P. Cunningham & William T. Newsome, 2020. "Value and choice as separable and stable representations in orbitofrontal cortex," Nature Communications, Nature, vol. 11(1), pages 1-19, December.
    6. Xulu Sun & Daniel J. O’Shea & Matthew D. Golub & Eric M. Trautmann & Saurabh Vyas & Stephen I. Ryu & Krishna V. Shenoy, 2022. "Cortical preparatory activity indexes learned motor memories," Nature, Nature, vol. 602(7896), pages 274-279, February.
    7. Mark M. Churchland & John P. Cunningham & Matthew T. Kaufman & Justin D. Foster & Paul Nuyujukian & Stephen I. Ryu & Krishna V. Shenoy, 2012. "Neural population dynamics during reaching," Nature, Nature, vol. 487(7405), pages 51-56, July.
    8. Jerry L. Chen & Stefano Carta & Joana Soldado-Magraner & Bernard L. Schneider & Fritjof Helmchen, 2013. "Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex," Nature, Nature, vol. 499(7458), pages 336-340, July.
    9. Nuo Li & Kayvon Daie & Karel Svoboda & Shaul Druckmann, 2016. "Robust neuronal dynamics in premotor cortex during motor planning," Nature, Nature, vol. 532(7600), pages 459-464, April.
    10. Nuo Li & Kayvon Daie & Karel Svoboda & Shaul Druckmann, 2016. "Correction: Corrigendum: Robust neuronal dynamics in premotor cortex during motor planning," Nature, Nature, vol. 537(7618), pages 122-122, September.
    11. Britton A. Sauerbrei & Jian-Zhong Guo & Jeremy D. Cohen & Matteo Mischiati & Wendy Guo & Mayank Kabra & Nakul Verma & Brett Mensh & Kristin Branson & Adam W. Hantman, 2020. "Cortical pattern generation during dexterous movement is input-driven," Nature, Nature, vol. 577(7790), pages 386-391, January.
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