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Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

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Listed:
  • Takahide Itokazu

    (University of Tübingen)

  • Masashi Hasegawa

    (University of Tübingen)

  • Rui Kimura

    (University of Tübingen)

  • Hironobu Osaki

    (University of Tübingen
    Tokyo Women’s Medical University)

  • Urban-Raphael Albrecht

    (University of Tübingen)

  • Kazuhiro Sohya

    (National Center of Neurology and Psychiatry)

  • Shubhodeep Chakrabarti

    (University of Tübingen)

  • Hideaki Itoh

    (Saga University)

  • Tetsufumi Ito

    (Kanazawa Medical University)

  • Tatsuo K. Sato

    (University of Tübingen
    Technical University of Munich)

  • Takashi R. Sato

    (University of Tübingen
    National Center of Neurology and Psychiatry
    Japan Science and Technology Agency)

Abstract

Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.

Suggested Citation

  • Takahide Itokazu & Masashi Hasegawa & Rui Kimura & Hironobu Osaki & Urban-Raphael Albrecht & Kazuhiro Sohya & Shubhodeep Chakrabarti & Hideaki Itoh & Tetsufumi Ito & Tatsuo K. Sato & Takashi R. Sato, 2018. "Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02501-4
    DOI: 10.1038/s41467-017-02501-4
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