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A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity

Author

Listed:
  • Claudia Kedor

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

  • Helma Freitag

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

  • Lil Meyer-Arndt

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
    Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Kirsten Wittke

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

  • Leif G. Hanitsch

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

  • Thomas Zoller

    (Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Fridolin Steinbeis

    (Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Milan Haffke

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

  • Gordon Rudolf

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

  • Bettina Heidecker

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin)

  • Thomas Bobbert

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin)

  • Joachim Spranger

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin)

  • Hans-Dieter Volk

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology
    Berlin Institute of Health)

  • Carsten Skurk

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin)

  • Frank Konietschke

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Friedemann Paul

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
    Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Uta Behrends

    (Technical University of Munich
    German Center for Infection Research (DZIF)
    Helmholtz Center Munich (HMGU))

  • Judith Bellmann-Strobl

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology
    a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
    Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Carmen Scheibenbogen

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology)

Abstract

A subset of patients has long-lasting symptoms after mild to moderate Coronavirus disease 2019 (COVID-19). In a prospective observational cohort study, we analyze clinical and laboratory parameters in 42 post-COVID-19 syndrome patients (29 female/13 male, median age 36.5 years) with persistent moderate to severe fatigue and exertion intolerance six months following COVID-19. Further we evaluate an age- and sex-matched postinfectious non-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome cohort comparatively. Most post-COVID-19 syndrome patients are moderately to severely impaired in daily live. 19 post-COVID-19 syndrome patients fulfill the 2003 Canadian Consensus Criteria for myalgic encephalomyelitis/chronic fatigue syndrome. Disease severity and symptom burden is similar in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome and non-COVID-19/myalgic encephalomyelitis/chronic fatigue syndrome patients. Hand grip strength is diminished in most patients compared to normal values in healthy. Association of hand grip strength with hemoglobin, interleukin 8 and C-reactive protein in post-COVID-19 syndrome/non-myalgic encephalomyelitis/chronic fatigue syndrome and with hemoglobin, N-terminal prohormone of brain natriuretic peptide, bilirubin, and ferritin in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome may indicate low level inflammation and hypoperfusion as potential pathomechanisms.

Suggested Citation

  • Claudia Kedor & Helma Freitag & Lil Meyer-Arndt & Kirsten Wittke & Leif G. Hanitsch & Thomas Zoller & Fridolin Steinbeis & Milan Haffke & Gordon Rudolf & Bettina Heidecker & Thomas Bobbert & Joachim S, 2022. "A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32507-6
    DOI: 10.1038/s41467-022-32507-6
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    References listed on IDEAS

    as
    1. Joshua Bond & Tessa Nielsen & Lynette Hodges, 2021. "Effects of Post-Exertional Malaise on Markers of Arterial Stiffness in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome," IJERPH, MDPI, vol. 18(5), pages 1-10, February.
    2. Nisreen A. Alwan, 2020. "A negative COVID-19 test does not mean recovery," Nature, Nature, vol. 584(7820), pages 170-170, August.
    3. Konietschke, Frank & Placzek, Marius & Schaarschmidt, Frank & Hothorn, Ludwig A., 2015. "nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 64(i09).
    Full references (including those not matched with items on IDEAS)

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