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Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

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  • Haniyeh Moaven

    (Centre for Oral Clinical Research, Centre for Oral Immunobiology & Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London E1 2AD, UK
    These authors contributed equally to this work.)

  • Annesi Giacaman

    (Center of Excellence in Translational Medicine, Faculty of Medicine, Universidad de la Frontera, Temuco 4780000, Chile
    These authors contributed equally to this work.)

  • Víctor Beltrán

    (Clinical Investigation and Dental Innovation Center, Dental School & Center for Translational Medicine, Universidad de La Frontera, Temuco 4780000, Chile)

  • Ye Han Sam

    (Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK)

  • Daniel Betancur

    (Discipline of Periodontology, Department of Surgical Stomatology, Faculty of Dentistry, Universidad de Concepción, Concepción 4030000, Chile)

  • Giuseppe Mainas

    (Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK)

  • Seyed Ali Tarjomani

    (Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK)

  • Nikolaos Donos

    (Centre for Oral Clinical Research, Centre for Oral Immunobiology & Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London E1 2AD, UK)

  • Vanessa Sousa

    (Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK)

Abstract

The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain ™ (EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.

Suggested Citation

  • Haniyeh Moaven & Annesi Giacaman & Víctor Beltrán & Ye Han Sam & Daniel Betancur & Giuseppe Mainas & Seyed Ali Tarjomani & Nikolaos Donos & Vanessa Sousa, 2022. "Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review," IJERPH, MDPI, vol. 19(21), pages 1-24, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14085-:d:956449
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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