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Impact of the COVID-19 Pandemic on the Therapeutic Continuity among Outpatients with Chronic Cardiovascular Therapies

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Listed:
  • Manuela Casula

    (Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    IRCCS MultiMedica, Via Milanese 300, Sesto S. Giovanni, 20099 Milan, Italy)

  • Federica Galimberti

    (IRCCS MultiMedica, Via Milanese 300, Sesto S. Giovanni, 20099 Milan, Italy)

  • Marica Iommi

    (Department of Medical and Surgical Sciences-Pharmacology Unit, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy)

  • Elena Olmastroni

    (Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy)

  • Simona Rosa

    (Department of Biomedical and Neuromotor Sciences-Hygiene and Biostatistics Unit, University of Bologna, Via San Giacomo, 40126 Bologna, Italy)

  • Mattia Altini

    (Romagna Local Health Authority, Emilia-Romagna Region, Via A. De Gasperi 8, 48121 Ravenna, Italy)

  • Alberico L. Catapano

    (Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    IRCCS MultiMedica, Via Milanese 300, Sesto S. Giovanni, 20099 Milan, Italy)

  • Elena Tragni

    (Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy)

  • Elisabetta Poluzzi

    (Department of Medical and Surgical Sciences-Pharmacology Unit, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy)

Abstract

The COVID-19 pandemic poses major challenges to healthcare systems. We aimed to investigate the impact of the pandemic on prescription and adherence patterns of chronic cardiovascular therapies (lipid-lowering [LL], oral antidiabetic drugs [AD], and antihypertensives [AH]) using administrative pharmaceutical databases. For each treatment, two cohorts of prevalent cases in 2019 and 2020 were compared. We evaluated the percentage change in dispensed packages and treatment adherence as a proportion of days covered (PDC). For all therapies, an increase was observed during March–April 2020 (LL: +4.52%; AD: +2.72%; AH: +1.09%), with a sharp decrease in May–June 2020 (LL: −8.40%; AD: −12.09%; AH: −10.54%) compared to 2019. The impact of the COVID-19 pandemic on chronic cardiovascular treatments appears negligible on adherence: 533,414 patients showed high adherence to LL (PDC ≥ 80%) in January–February 2020, and 2.29% became poorly adherent (PDC < 20%) in the following four-month period (vs. 1.98% in 2019). A similar increase was also observed for AH (1.25% with poor adherence in 2020 vs. 0.93% in 2019). For AD, the increase was restrained (1.55% with poor adherence in 2020 vs. 1.37% in 2019). The rush to supply drugs at the beginning of lockdown preserved the continuity of chronic cardiovascular therapies.

Suggested Citation

  • Manuela Casula & Federica Galimberti & Marica Iommi & Elena Olmastroni & Simona Rosa & Mattia Altini & Alberico L. Catapano & Elena Tragni & Elisabetta Poluzzi, 2022. "Impact of the COVID-19 Pandemic on the Therapeutic Continuity among Outpatients with Chronic Cardiovascular Therapies," IJERPH, MDPI, vol. 19(19), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12101-:d:924188
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    References listed on IDEAS

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    1. Santeramo, Fabio Gaetano & Tappi, Marco & Lamonaca, Emilia, 2021. "On the management of COVID-19 pandemic in Italy," Health Policy, Elsevier, vol. 125(8), pages 995-1001.
    2. Jeffrey Clement & Maura Jacobi & Brad N Greenwood, 2021. "Patient access to chronic medications during the Covid-19 pandemic: Evidence from a comprehensive dataset of US insurance claims," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-13, April.
    3. Flaminia Ortenzi & Emiliano Albanese & Marta Fadda, 2020. "A Transdisciplinary Analysis of COVID-19 in Italy: The Most Affected Country in Europe," IJERPH, MDPI, vol. 17(24), pages 1-12, December.
    4. Gianluca Trifirò & Rosa Gini & Francesco Barone-Adesi & Ettore Beghi & Anna Cantarutti & Annalisa Capuano & Carla Carnovale & Antonio Clavenna & Mirosa Dellagiovanna & Carmen Ferrajolo & Matteo Franch, 2019. "The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?," Drug Safety, Springer, vol. 42(3), pages 347-363, March.
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    Cited by:

    1. Michał Święczkowski & Sławomir Dobrzycki & Łukasz Kuźma, 2023. "Multi-City Analysis of the Acute Effect of Polish Smog on Cause-Specific Mortality (EP-PARTICLES Study)," IJERPH, MDPI, vol. 20(8), pages 1-17, April.
    2. Elena Olmastroni & Federica Galimberti & Elena Tragni & Alberico L. Catapano & Manuela Casula, 2023. "Impact of COVID-19 Pandemic on Adherence to Chronic Therapies: A Systematic Review," IJERPH, MDPI, vol. 20(5), pages 1-15, February.

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