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Association between High-Sensitive C-Reactive Protein and the Development of Liver Damage in Japanese Male Workers

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  • Reiko Kuroda

    (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    Division for Environment, Health and Safety, The University of Tokyo, Tokyo 113-8654, Japan)

  • Kazuhiro Nogawa

    (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan)

  • Yuuka Watanabe

    (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan)

  • Hideki Morimoto

    (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan)

  • Kouichi Sakata

    (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan)

  • Yasushi Suwazono

    (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan)

Abstract

Background: The aim of this study was to determine whether a causative relationship exists between the development of liver damage and increased high-sensitivity C-reactive protein (HsCRP) levels by long-term follow-up in Japanese workers. Methods: The target participants comprised 7830 male workers in a Japanese steel company. The prospective cohort study was performed over a 6-year period, and annual health screening information was analyzed by pooled logistic regression. The endpoint, regarded as the development of liver damage, was defined as aspartate aminotransferase (AST) ≥ 40 IU/L. Results: A significant relationship between the development of liver damage and increased HsCRP levels was observed after adjusting for confounding factors such as various physiological and blood chemistry parameters and lifestyle factors. The odds ratio of a 1.5-fold increase in HsCRP was 1.07 (95% confidence interval: 1.03–1.10, p < 0.001). Conclusions: The results suggested that an increase of HsCRP is associated with the development of liver damage.

Suggested Citation

  • Reiko Kuroda & Kazuhiro Nogawa & Yuuka Watanabe & Hideki Morimoto & Kouichi Sakata & Yasushi Suwazono, 2021. "Association between High-Sensitive C-Reactive Protein and the Development of Liver Damage in Japanese Male Workers," IJERPH, MDPI, vol. 18(6), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:2985-:d:516789
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    References listed on IDEAS

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    1. Gökhan S. Hotamisligil, 2006. "Inflammation and metabolic disorders," Nature, Nature, vol. 444(7121), pages 860-867, December.
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